DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TH1 and NELFCD

DIOPT Version :9

Sequence 1:	NP_001285326.1	Gene:	TH1 / 32607	FlyBaseID:	FBgn0010416	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_945327.3	Gene:	NELFCD / 51497	HGNCID:	15934	Length:	581	Species:	Homo sapiens

Alignment Length:	583	Identity:	314/583 - (53%)
Similarity:	443/583 - (75%)	Gaps:	8/583 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEVEYDDSG--WQGRAKGQTNPEETLE-DNPQKTIQECLEKFLTPDYIMEPGIFTQLKRYFQSGG 62
            |:.:|..|.  |...|.|....:::.| ::..:..||||.||.|.||||||.||..||||||:||
Human     1 MDEDYYGSAAEWGDEADGGQQEDDSGEGEDDAEVQQECLHKFSTRDYIMEPSIFNTLKRYFQAGG 65

  Fly    63 SPEEVISMLSENYKAVAQMANLLAEWLILAGVKVTEVQAMVENHLKEMILKSFDPKKADTIFTEE 127
            |||.||.:|||||.||||..||||||||..||:..:||..||||||.:::|.|||:|||:|||||
Human    66 SPENVIQLLSENYTAVAQTVNLLAEWLIQTGVEPVQVQETVENHLKSLLIKHFDPRKADSIFTEE 130

  Fly   128 GETPDWLTEMIDHYTWRSLIYRLAEEYPDCLMLNFTIKLISDAGFQSEITSISTAAQQIEVFSRV 192
            ||||.||.:||.|.|||.|.|:|||.:|||||||||:|||||||:|.||||:|||.||:||||||
Human   131 GETPAWLEQMIAHTTWRDLFYKLAEAHPDCLMLNFTVKLISDAGYQGEITSVSTACQQLEVFSRV 195

  Fly   193 LKTSIVKFLN-NPDDVHGAIQECARMVCHGQHTYVYSQVLIQVLSQEQKGGFNMKRLSQEIIKYA 256
            |:||:...|: ..:::...:.|.|:|||||:|||:::|.::.||:||::||..::|::||:.::|
Human   196 LRTSLATILDGGEENLEKNLPEFAKMVCHGEHTYLFAQAMMSVLAQEEQGGSAVRRIAQEVQRFA 260

  Fly   257 LQNNQNVTPITMALNGSAVYPQACQALTSMLTRNTLNPADITVLFRNYSGSDPPPIDLIRNPQFL 321
            .:...:.:.||:||..:|.||:|||||.:||::..||||||||||:.::..||||::|||.|.||
Human   261 QEKGHDASQITLALGTAASYPRACQALGAMLSKGALNPADITVLFKMFTSMDPPPVELIRVPAFL 325

  Fly   322 ELLVDALFRSGVKINPEHKPKYMFLLAYASAVIDQPAKKRPMTERMLNKEELKSTIQAIEKAHTI 386
            :|.:.:||:.|.:||.:||.||:.:||||::|::...|.:.::   :||:|||||.:|:|..|.:
Human   326 DLFMQSLFKPGARINQDHKHKYIHILAYAASVVETWKKNKRVS---INKDELKSTSKAVETVHNL 387

  Fly   387 -CNVDQGSTELIAELQTLYNCIKYPVVGVGVIRWIENVVMEPSYFKLSTDSCPTHLAVLDEVAAV 450
             ||.::|::||:|||.|||.||::|||.:||::|::..|.||.||:|.||..|.|||:|||::..
Human   388 CCNENKGASELVAELSTLYQCIRFPVVAMGVLKWVDWTVSEPRYFQLQTDHTPVHLALLDEISTC 452

  Fly   451 HPTLQQQILFLLIRLFESKQDELEILVQLEMKKMILDRMVNLLTRGCVVPVLRYIKQCCAIEDTD 515
            |..|..|:|.||::|||::..:|:::.|||:||.:|||||:||:||.|:||:.||::|....|||
Human   453 HQLLHPQVLQLLVKLFETEHSQLDVMEQLELKKTLLDRMVHLLSRGYVLPVVSYIRKCLEKLDTD 517

  Fly   516 ISLIRYFVTEVLETITHPYSPEFVQLFLPMVENEEITGTMRGEGDNDPVSEFIVHCKAHYTTV 578
            ||||||||||||:.|..||:.:|||||||::||:.|.||::.||::|||:|||.|||:::..|
Human   518 ISLIRYFVTEVLDVIAPPYTSDFVQLFLPILENDSIAGTIKTEGEHDPVTEFIAHCKSNFIMV 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TH1	NP_001285326.1	TH1	2..576	CDD:398497	312/578 (54%)
NELFCD	NP_945327.3	TH1	2..578	CDD:398497	312/578 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157784
Domainoid	1	1.000	652	1.000	Domainoid score	I155
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9496
Inparanoid	1	1.050	653	1.000	Inparanoid score	I787
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54582
OrthoDB	1	1.010	-	-		D1288184at2759
OrthoFinder	1	1.000	-	-		FOG0008383
OrthoInspector	1	1.000	-	-		oto88779
orthoMCL	1	0.900	-	-		OOG6_105505
Panther	1	1.100	-	-	LDO	PTHR12144
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4685
SonicParanoid	1	1.000	-	-		X6371
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940