DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TH1 and nelfcd

DIOPT Version :9

Sequence 1:	NP_001285326.1	Gene:	TH1 / 32607	FlyBaseID:	FBgn0010416	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_957484.1	Gene:	nelfcd / 394165	ZFINID:	ZDB-GENE-040426-720	Length:	579	Species:	Danio rerio

Alignment Length:	583	Identity:	313/583 - (53%)
Similarity:	436/583 - (74%)	Gaps:	19/583 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EVEYDDSG-WQGRAKGQTNPEETLEDN------PQKTIQECLEKFLTPDYIMEPGIFTQLKRYFQ 59
            |..|..:| |:.:       :.::||.      ..|..::||:||.:.||||||.:|..||.|||
Zfish     3 EEYYSHAGEWEAQ-------DGSMEDGYGDAEADGKVQEDCLQKFSSRDYIMEPTVFNTLKSYFQ 60

  Fly    60 SGGSPEEVISMLSENYKAVAQMANLLAEWLILAGVKVTEVQAMVENHLKEMILKSFDPKKADTIF 124
            :|||||.||.:|||||.||||..||||||||..||:..:||..||||||.:::|.|||:|||:||
Zfish    61 AGGSPEHVIQLLSENYSAVAQTVNLLAEWLIQMGVEPAQVQERVENHLKSLLIKHFDPQKADSIF 125

  Fly   125 TEEGETPDWLTEMIDHYTWRSLIYRLAEEYPDCLMLNFTIKLISDAGFQSEITSISTAAQQIEVF 189
            |.|||||.||.:||.|.|||.|.|:|||.:|||||||||:|||||||:|.||||:|||.||:|||
Zfish   126 TVEGETPAWLEQMIAHTTWRDLFYKLAEAHPDCLMLNFTVKLISDAGYQGEITSVSTACQQLEVF 190

  Fly   190 SRVLKTSIVKFLNNPD-DVHGAIQECARMVCHGQHTYVYSQVLIQVLSQEQKGGFNMKRLSQEII 253
            ||||:||:...|:..: ::...:.|.|:|||||:|||:::|.::.:|:||::||..|:|:.||:.
Zfish   191 SRVLRTSLATLLDGGEQNLEKNLPEFAKMVCHGEHTYLFAQAMMSILAQEEQGGSAMRRIGQEVQ 255

  Fly   254 KYALQNNQNVTPITMALNGSAVYPQACQALTSMLTRNTLNPADITVLFRNYSGSDPPPIDLIRNP 318
            |||.:...:.:.||:||..:|.||:|||||.:||::..||||||||||:.:|..||||::|||.|
Zfish   256 KYAHERGHDASQITLALGTAAAYPRACQALGAMLSKGALNPADITVLFKMFSSMDPPPVELIRVP 320

  Fly   319 QFLELLVDALFRSGVKINPEHKPKYMFLLAYASAVIDQPAKKRPMTERMLNKEELKSTIQAIEKA 383
            .||:|.:.:||:.|.|||.:||.||:.:||||::|::...|.:.:.   :||:|||||.:|||..
Zfish   321 AFLDLFMQSLFKPGAKINQDHKHKYIHILAYAASVVETWKKNKRVN---INKDELKSTSKAIETV 382

  Fly   384 HTI-CNVDQGSTELIAELQTLYNCIKYPVVGVGVIRWIENVVMEPSYFKLSTDSCPTHLAVLDEV 447
            |.: ||.::|:|||:|.|.|||.||::|||.:||::|::..|.||.||:|.||..|.|||:|||:
Zfish   383 HNLCCNENKGATELVAGLSTLYQCIRFPVVAMGVLKWVDWTVSEPRYFQLQTDHTPVHLALLDEI 447

  Fly   448 AAVHPTLQQQILFLLIRLFESKQDELEILVQLEMKKMILDRMVNLLTRGCVVPVLRYIKQCCAIE 512
            :..|..|..|:|.|||:|||::..:|:::.|:|:||.:|||||:||:||.|:||:.||::|....
Zfish   448 STCHQLLHPQVLQLLIKLFETEHSQLDVMEQMELKKTLLDRMVHLLSRGYVLPVVGYIRKCLEKL 512

  Fly   513 DTDISLIRYFVTEVLETITHPYSPEFVQLFLPMVENEEITGTMRGEGDNDPVSEFIVHCKAHY 575
            :||||||||||||||:.|..||:.:|||||||::||:.|.||:|.||:||||:|||.|||:::
Zfish   513 NTDISLIRYFVTEVLDVIAPPYTSDFVQLFLPILENDSIAGTIRTEGENDPVAEFIAHCKSNF 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TH1	NP_001285326.1	TH1	2..576	CDD:398497	313/583 (54%)
nelfcd	NP_957484.1	TH1	2..576	CDD:282684	313/583 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593572
Domainoid	1	1.000	648	1.000	Domainoid score	I155
eggNOG	1	0.900	-	-		E1_28HGD
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9496
Inparanoid	1	1.050	648	1.000	Inparanoid score	I780
OMA	1	1.010	-	-		QHG54582
OrthoDB	1	1.010	-	-		D1288184at2759
OrthoFinder	1	1.000	-	-		FOG0008383
OrthoInspector	1	1.000	-	-		oto39703
orthoMCL	1	0.900	-	-		OOG6_105505
Panther	1	1.100	-	-	LDO	PTHR12144
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4685
SonicParanoid	1	1.000	-	-		X6371
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800