DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and PRB1

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_010854.1	Gene:	PRB1 / 856649	SGDID:	S000000786	Length:	635	Species:	Saccharomyces cerevisiae

Alignment Length:	710	Identity:	134/710 - (18%)
Similarity:	232/710 - (32%)	Gaps:	223/710 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 SLHSSRRTNPPSSSSSSSSNVDVDYRNDRELHKVDLVGLGG-------ERAGQAETISGGKYDYN 198
            |.|...:...|...||:..  |.|.:..:..||      ||       |:..:.:.:.|.|:
Yeast    94 SAHEGGKGMKPKHESSNDD--DNDDKKKKPHHK------GGCHENKVEEKKMKGKKVKGKKH--- 147

  Fly   199 YENTHTNASAKDEIVERQSNSLDFDGVDMFGAFSIPEEAIYTNEFAVNIPAGKQMADVIATKHGF 263
            :|.|.......:.:....|.:       .|...:|.:  |..|.:.:....|....::...|..
Yeast   148 HEKTLEKGRHHNRLAPLVSTA-------QFNPDAISK--IIPNRYIIVFKRGAPQEEIDFHKEN- 202

  Fly   264 INRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSENEVKWMQQQHEKVRRKRDGPYQDLPTY 328
            :.:.|:.|::|........:|.:....|....|.:                        ||  ::
Yeast   203 VQQAQLQSVENLSAEDAFFISTKDTSLSTSEAGGI------------------------QD--SF 241

  Fly   329 SPYNLLRQHGGY----VVD---PNPHLSF-----------------SPESISLASHSQRMEYRDV 369
            :..||...:.||    :||   .||.:.|                 :|..::..||.:|:.....
Yeast   242 NIDNLFSGYIGYFTQEIVDLIRQNPLVDFVERDSIVEATEFDTQNSAPWGLARISHRERLNLGSF 306

  Fly   370 SSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNY 434
            :.:....|                                .|:||...::|.|:..||.|..:..
Yeast   307 NKYLYDDD--------------------------------AGRGVTSYVIDTGVNINHKDFEKRA 339

  Fly   435 DPEASFDINGNDSDPTPQDNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRML----DGK 495
            ....:..:|..|.|       .|.|||.|||.:|:..:      |||.||::..|::|    .|.
Yeast   340 IWGKTIPLNDEDLD-------GNGHGTHCAGTIASKHY------GVAKNANVVAVKVLRSNGSGT 391

  Fly   496 VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVD-----GPGPLARRAFIYGVTSGRQGKGSIFV 555
            ::|||:....:......:......|.:  |||.:     |..|....|....|..|..     |.
Yeast   392 MSDVVKGVEYAAKAHQKEAQEKKKGFK--GSTANMSLGGGKSPALDLAVNAAVEVGIH-----FA 449

  Fly   556 WASGNGGRYTDSCNCD-GYTNSIFTLSIS--SATQAGFKPWYLEECSSTLA------TTYSSGTP 611
            .|:||..:  |:||.. ...:...|:..|  |..:|.|..|  .:|....|      :||.
Yeast   450 VAAGNENQ--DACNTSPASADKAITVGASTLSDDRAYFSNW--GKCVDVFAPGLNILSTYI---- 506

  Fly   612 GHDKSVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPA 676
            |.|.:.||:                :|||.::|..||:....|...|   ..|.::..:
Yeast   507 GSDDATATL----------------SGTSMASPHVAGLLTYFLSLQP---GSDSEFFEL------ 546

  Fly   677 PLEKENGWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGST 741
               .::..|...:|:|..|   |...|  .:..:.|...:|       ...|...:.:...:..|
Yeast   547 ---GQDSLTPQQLKKKLIH---YSTKD--ILFDIPEDTPNV-------LIYNGGGQDLSAFWNDT 596

  Fly   742 LSTHMDVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIV 801
            ..:|     .:|...|:...|.:                      |:.:.|:|::.|||:
Yeast   597 KKSH-----SSGFKQELNMDEFI----------------------GSKTDLIFDQVRDIL 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	8/75 (11%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	70/316 (22%)
		Peptidase_S8	411..700	CDD:278510	73/306 (24%)
		P_proprotein	761..849	CDD:279782	7/41 (17%)
		Furin-like	966..1126	CDD:279142
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
PRB1	NP_010854.1	Inhibitor_I9	182..278	CDD:399132	19/122 (16%)
PRB1	NP_010854.1	Peptidases_S8_PCSK9_ProteinaseK_like	290..566	CDD:173790	78/366 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810