Protein Alignment Fur2 and RRT12

DIOPT Version :9

• Sequence 1: NP_727963.1
• Gene: Fur2 / 32604
• FlyBaseID: FBgn0004598
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: NP_009974.1
• Gene: RRT12 / 850412
• SGDID: S000000641
• Length: 491
• Species: Saccharomyces cerevisiae
• Alignment Length: 568
• Identity: 119/568 - (20%)
• Similarity: 191/568 - (33%)
• Gaps: 176/568 - (30%)

  Fly   300 SENEVKWMQQQHEKVRRKRD-GPYQDLPTYSPYNLLR--QHGGYVVDPNPHL---SFSPESISLA 358
            |.:...|.|....|:.:|.. |.::.:......||:.  :....|.|..|:.   :|..:|::.|
Yeast    35 SNSNRSWRQFIDNKIEKKFSIGSFRGVTMNLSKNLVNKLKKSPLVADIVPNFRFEAFEGDSVNSA 99

  Fly   359 SHS------QRMEYRDV-------------------SSHFIFPDPLFKEQWYLVSKNGGAKDGLD 398
            ..|      .:..|.||                   |.|:..|..:            |.||...
Yeast   100 ESSYTFNATAKYSYEDVEEEQNITYQPDAPRHLARISRHYQLPFDV------------GDKDRYK 152

  Fly   399 MNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPEASFDINGNDSDPTPQDNGD-NKHGTR 462
            ......::..|.|:.|...|:|.||..:||:.....       |.|  .|.|.:..|| |.|||.
Yeast   153 SWFNYYYEHDYQGQDVNAYIMDTGIFADHPEFEDRV-------IQG--IDLTKEGFGDQNGHGTH 208

  Fly   463 CAGEVAAVAFNNFCGVGVAYNASIGGVRML----DGKVNDVVEAQALSLNPSHIDIYSASWGPED 523
            .||.|.:..:      |.|...::..|::|    .|:.::|:  ..|.....|....|...|.:.
Yeast   209 VAGLVGSKTY------GAAKRVNLVEVKVLGKDGSGEASNVL--SGLEFIVEHCTKVSRPQGKKC 265

  Fly   524 DGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGNGGRYTDSCNCDGY------TNSIFTLSI 582
            ..:...|.   .|...|.....|...:|.:||.|:||       .|.|.|      ..::.|:..
Yeast   266 VANLSLGS---FRSPIINMAVEGAIEEGIVFVAAAGN-------FNLDAYWASPASAENVITVGA 320

  Fly   583 SS---ATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGSLRPDHICTVEHTGTSASAP 644
            ..   .|.|.|..|  ..|.:..|       ||       |:::.....::..|:..:|||.|.|
Yeast   321 FDDHIDTIAKFSNW--GPCVNIFA-------PG-------VEIESLSHLNYNDTLILSGTSMSTP 369

  Fly   645 LAAGICALALE--ANPELTWRDMQYL---------VVYTSRPAPLEKENGWTLNGVKR---KYSH 695
            :..|:.|:.|.  ..||:..::::||         .::.....|    |....|||.:   .|..
Yeast   370 IVTGVAAILLSKGIEPEMIAQEIEYLSTRNVFHRRTLFFKPSTP----NQILYNGVDKLDDPYDD 430

  Fly   696 KFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGCAGT-----I 755
                            |.:..:..:.|.|..|.         |.:||.|.|..|..:|:     .
Yeast   431 ----------------ETFPRLNIEAIAKELEE---------YNATLQTPMSENLQSGSKLWGWN 470

  Fly   756 NEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKS 803
            |:|          ||   |.|.:|:               :.||.:|:
Yeast   471 NDV----------TL---PLGEIRL---------------KRRDFMKN 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	4/17 (24%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	72/323 (22%)
		Peptidase_S8	411..700	CDD:278510	73/316 (23%)
		P_proprotein	761..849	CDD:279782	8/43 (19%)
		Furin-like	966..1126	CDD:279142
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
RRT12	NP_009974.1	Peptidases_S8_PCSK9_ProteinaseK_like	130..398	CDD:173790	74/322 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810