DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and FRAS1

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_079350.5	Gene:	FRAS1 / 80144	HGNCID:	19185	Length:	4012	Species:	Homo sapiens

Alignment Length:	852	Identity:	229/852 - (26%)
Similarity:	326/852 - (38%)	Gaps:	195/852 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   967 LHSCDAECDSSGCYGRGPTQCVACSHYRLDNTCVS----------------RCPPR---SFPNQV 1012
            :|||     ..|.|..| :.|:||...  .:||.|                :|.|.   .|....
Human   451 VHSC-----GLGFYQAG-SLCLACQPQ--CSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDR 507

  Fly  1013 GICWPCHDTCETCAGAGPDSCLTCAPAHLHVIDLAVCLQFCPDGYFENSRNRTCVPCEPNCASCQ 1077
            ..|..||::|..|.|.....||.|... |||:....|...|..|::  :|..||..|:.:|.||.
Human   508 HSCAVCHESCAGCWGPTEKHCLACRDP-LHVLRDGGCESSCGKGFY--NRQGTCSACDQSCDSCG 569

  Fly  1078 DHPEYCTSCDHHLVMHEHKCYSACPLDTYETEDNKCAFCHSTCATCNGPTDQDCITCRSSRYAWQ 1142
            .....|.:|....|:|:.||.|.||...|.....:|..||::||:|:|||...|..|...:...|
Human   570 PSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQ 634

  Fly  1143 NKCLISCPDGFYADKKRLECMPCQEGCKTC--TSNGVCSEC------LQNWTLNKRDKCIVSGSE 1199
            ..||..|.:|||:|..  .|..|...|..|  .:...|:.|      ||...|:  |..|.||.
Human   635 GHCLPRCGEGFYSDHG--VCKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLS--DVGIPSGE- 694

  Fly  1200 GC---SESEFYSQVEGQCRPCHASCGSCNGPADTSCTSCPPNRLLEQSRCVSGCREGFFVEAGSL 1261
             |   ..:.||.:..|.|..||.||..|.|.:..:||.|.|:.:|...:|:|.|.:|:|.:.||
Human   695 -CLAQCRAHFYLESTGICEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGS- 757

  Fly  1262 CSPCLHTCSQCVS--RTNCSNCSKGLELQNGECRTTCADGYYSDR-GICAKCYLSCHTCSGPRRN 1323
            |:.|..||.||..  .::|.:|...:.|.||.|||:|.:..:.:. |.||.|:..|..|:....|
Human   758 CTECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHN 822

  Fly  1324 Q---CVQCPAGWQLAAGE-CHPECPEGFYKSDFGCQKCHHYCKTCNDAGPLACTSC--------- 1375
            .   |::|.....|..|: |.|:||.|:|.....|:|||..|:||...||.:|:||
Human   823 TGSICLRCQNAHYLLLGDHCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHT 887

  Fly  1376 --------PPHSMLDGGLCMEC--------------------------------LSSQYY-DTTS 1399
                    |.|.:.|..:|..|                                .:.||| |.::
Human   888 GTCSTTCFPGHYLDDNHVCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFST 952

  Fly  1400 ATCKTCHDSCRSCFGPGQFSCKGCVPPLHLDQLNSQCVSCCQNQTLAEKTSSAACCNCDG----- 1459
            .|||.|..||.:|.||.:..|..|:....|.  :..||..|.:....:   |..|.|||.
Human   953 NTCKECDWSCSACSGPLKTDCLQCMDGYVLQ--DGACVEQCLSSFYQD---SGLCKNCDSYCLQC 1012

  Fly  1460 ----ETGECKATSTGGKRRTVVGSGSAYKSSESKH-------GSFENDGNAR------EFVLRLD 1507
                |...||......:.:.|...|..|.:..:||       |..:.....|      .|.|:
Human  1013 QGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRCHLCDHGFFLK-- 1075

  Fly  1508 SPLTAITAIAVAICLLIITIFSIIFAVLQRNSNHVSRNSVRYRKIANTSSGRRKNL-----SAKP 1567
                  :.:.|..|   :..||:          |.| |.....||...|.....:|     |.||
Human  1076 ------SGLCVYNC---VPGFSV----------HTS-NETCSGKIHTPSLHVNGSLILPIGSIKP 1120

  Fly  1568 TSDARFIFNIGEDDDTDGDNSDDELDGNVGTDINNRIVYDRKGN----DHGHEFYIESTNDIDAI 1628
            ..     |::....|.:| ..:|.|...|.|..|.::|..|.|.    |....|..:..|: ..:
Human  1121 LD-----FSLLNVQDQEG-RVEDLLFHVVSTPTNGQLVLSRNGKEVQLDKAGRFSWKDVNE-KKV 1178

  Fly  1629 EFHCNGAGAQK-------------AETQLQRCNANGDD------DDILHYDRHTNAERKNHPSST 1674
            .|..:....:|             :|.||....|....      :::||..|...|      :.|
Human  1179 RFVHSKEKLRKGYLFLKISDQQFFSEPQLINIQAFSTQAPYVLRNEVLHISRGERA------TIT 1237

  Fly  1675 TSRTNIR 1681
            |...:||
Human  1238 TQMLDIR 1244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789
		Peptidase_S8	411..700	CDD:278510
		P_proprotein	761..849	CDD:279782
		Furin-like	966..1126	CDD:279142	53/177 (30%)
		FU	970..1013	CDD:238021	13/61 (21%)
		FU	1017..1067	CDD:238021	16/49 (33%)
		FU	1063..1106	CDD:214589	15/42 (36%)
		GF_recep_IV	1068..1232	CDD:291509	57/174 (33%)
		FU	1116..1163	CDD:238021	18/46 (39%)
		FU	1211..1255	CDD:214589	17/43 (40%)
		FU	1259..1301	CDD:214589	17/43 (40%)
		FU	1304..1348	CDD:214589	16/48 (33%)
		FU	1356..1403	CDD:238021	21/96 (22%)
		FU	1401..1444	CDD:214589	15/42 (36%)
FRAS1	NP_079350.5	VWC	28..87	CDD:214564
		VWC	95..152	CDD:278520
		VWC	159..216	CDD:278520
		VWC	221..278	CDD:278520
		VWC	285..342	CDD:214564
		VWC	367..416	CDD:214564
		FU 1	409..460		4/13 (31%)
		Furin-like	462..620	CDD:279142	50/163 (31%)
		FU 2	462..505		10/45 (22%)
		FU	462..504	CDD:214589	9/44 (20%)
		FU 3	507..553		15/48 (31%)
		FU	507..552	CDD:214589	15/45 (33%)
		FU 4	555..599		15/43 (35%)
		FU	556..598	CDD:214589	15/41 (37%)
		FU 5	602..647		17/44 (39%)
		FU	608..653	CDD:238021	18/46 (39%)
		FU 6	649..705		15/61 (25%)
		FU	650..704	CDD:214589	14/59 (24%)
		GF_recep_IV	655..777	CDD:291509	41/126 (33%)
		FU 7	708..753		17/44 (39%)
		FU	708..752	CDD:214589	17/43 (40%)
		FU 8	755..800		17/45 (38%)
		FU	755..799	CDD:214589	17/44 (39%)
		FU 9	803..852		16/48 (33%)
		FU	804..851	CDD:214589	16/46 (35%)
		Furin-like	841..1056	CDD:279142	55/219 (25%)
		FU 10	854..900		14/45 (31%)
		FU	859..907	CDD:238021	14/47 (30%)
		FU 11	903..948		4/44 (9%)
		FU 12	952..997		15/46 (33%)
		FU	952..996	CDD:214589	15/45 (33%)
		FU 13	999..1042		11/42 (26%)
		FU	999..1041	CDD:214589	10/41 (24%)
		Furin-like_2	1009..1099	CDD:292535	19/111 (17%)
		FU 14	1046..1089		9/53 (17%)
		FU	1046..1087	CDD:214589	8/51 (16%)
		Cadherin_3	<1101..1183	CDD:292802	20/88 (23%)
		CSPG 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1102..1197		21/101 (21%)
		Cadherin_3	1168..1310	CDD:292802	16/84 (19%)
		CSPG 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1217..1308		8/34 (24%)
		Cadherin_3	1279..1438	CDD:292802
		CSPG 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1329..1438
		Cadherin_3	1409..1574	CDD:292802
		CSPG 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1463..1559
		Cadherin_3	1529..1691	CDD:292802
		CSPG 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1595..1689
		Cadherin_3	1660..1811	CDD:292802
		CSPG 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1710..1810
		Cadherin_3	1778..1938	CDD:292802
		CSPG 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1833..1936
		Cadherin_3	1904..2059	CDD:292802
		CSPG 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1957..2057
		Cadherin_3	2028..2179	CDD:292802
		CSPG 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2078..2177
		Cadherin_3	2147..2293	CDD:292802
		CSPG 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2199..2291
		Cadherin_3	2261..2406	CDD:292802
		CSPG 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2311..2404
		Cadherin_3	2375..2537	CDD:292802
		CSPG 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2439..2536
		Calx_beta	2555..2650	CDD:197594
		Calx-beta	2675..2764	CDD:295344
		Calx-beta	2798..2894	CDD:295344
		Calx-beta	2920..3011	CDD:295344
Calx-beta	3039..3133	CDD:295344
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	228	1.000	Domainoid score	I2495
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810