DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fur2 and FRAS1

DIOPT Version :10

Sequence 1:NP_727963.1 Gene:Fur2 / 32604 FlyBaseID:FBgn0004598 Length:1682 Species:Drosophila melanogaster
Sequence 2:NP_079350.5 Gene:FRAS1 / 80144 HGNCID:19185 Length:4012 Species:Homo sapiens


Alignment Length:852 Identity:229/852 - (26%)
Similarity:326/852 - (38%) Gaps:195/852 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   967 LHSCDAECDSSGCYGRGPTQCVACSHYRLDNTCVS----------------RCPPR---SFPNQV 1012
            :|||     ..|.|..| :.|:||...  .:||.|                :|.|.   .|....
Human   451 VHSC-----GLGFYQAG-SLCLACQPQ--CSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDR 507

  Fly  1013 GICWPCHDTCETCAGAGPDSCLTCAPAHLHVIDLAVCLQFCPDGYFENSRNRTCVPCEPNCASCQ 1077
            ..|..||::|..|.|.....||.|... |||:....|...|..|::  :|..||..|:.:|.||.
Human   508 HSCAVCHESCAGCWGPTEKHCLACRDP-LHVLRDGGCESSCGKGFY--NRQGTCSACDQSCDSCG 569

  Fly  1078 DHPEYCTSCDHHLVMHEHKCYSACPLDTYETEDNKCAFCHSTCATCNGPTDQDCITCRSSRYAWQ 1142
            .....|.:|....|:|:.||.|.||...|.....:|..||::||:|:|||...|..|...:...|
Human   570 PSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQ 634

  Fly  1143 NKCLISCPDGFYADKKRLECMPCQEGCKTC--TSNGVCSEC------LQNWTLNKRDKCIVSGSE 1199
            ..||..|.:|||:|..  .|..|...|..|  .:...|:.|      ||...|:  |..|.||. 
Human   635 GHCLPRCGEGFYSDHG--VCKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLS--DVGIPSGE- 694

  Fly  1200 GC---SESEFYSQVEGQCRPCHASCGSCNGPADTSCTSCPPNRLLEQSRCVSGCREGFFVEAGSL 1261
             |   ..:.||.:..|.|..||.||..|.|.:..:||.|.|:.:|...:|:|.|.:|:|.:.|| 
Human   695 -CLAQCRAHFYLESTGICEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGS- 757

  Fly  1262 CSPCLHTCSQCVS--RTNCSNCSKGLELQNGECRTTCADGYYSDR-GICAKCYLSCHTCSGPRRN 1323
            |:.|..||.||..  .::|.:|...:.|.||.|||:|.:..:.:. |.||.|:..|..|:....|
Human   758 CTECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHN 822

  Fly  1324 Q---CVQCPAGWQLAAGE-CHPECPEGFYKSDFGCQKCHHYCKTCNDAGPLACTSC--------- 1375
            .   |::|.....|..|: |.|:||.|:|.....|:|||..|:||...||.:|:||         
Human   823 TGSICLRCQNAHYLLLGDHCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHT 887

  Fly  1376 --------PPHSMLDGGLCMEC--------------------------------LSSQYY-DTTS 1399
                    |.|.:.|..:|..|                                .:.||| |.::
Human   888 GTCSTTCFPGHYLDDNHVCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFST 952

  Fly  1400 ATCKTCHDSCRSCFGPGQFSCKGCVPPLHLDQLNSQCVSCCQNQTLAEKTSSAACCNCDG----- 1459
            .|||.|..||.:|.||.:..|..|:....|.  :..||..|.:....:   |..|.|||.     
Human   953 NTCKECDWSCSACSGPLKTDCLQCMDGYVLQ--DGACVEQCLSSFYQD---SGLCKNCDSYCLQC 1012

  Fly  1460 ----ETGECKATSTGGKRRTVVGSGSAYKSSESKH-------GSFENDGNAR------EFVLRLD 1507
                |...||......:.:.|...|..|.:..:||       |..:.....|      .|.|:  
Human  1013 QGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRCHLCDHGFFLK-- 1075

  Fly  1508 SPLTAITAIAVAICLLIITIFSIIFAVLQRNSNHVSRNSVRYRKIANTSSGRRKNL-----SAKP 1567
                  :.:.|..|   :..||:          |.| |.....||...|.....:|     |.||
Human  1076 ------SGLCVYNC---VPGFSV----------HTS-NETCSGKIHTPSLHVNGSLILPIGSIKP 1120

  Fly  1568 TSDARFIFNIGEDDDTDGDNSDDELDGNVGTDINNRIVYDRKGN----DHGHEFYIESTNDIDAI 1628
            ..     |::....|.:| ..:|.|...|.|..|.::|..|.|.    |....|..:..|: ..:
Human  1121 LD-----FSLLNVQDQEG-RVEDLLFHVVSTPTNGQLVLSRNGKEVQLDKAGRFSWKDVNE-KKV 1178

  Fly  1629 EFHCNGAGAQK-------------AETQLQRCNANGDD------DDILHYDRHTNAERKNHPSST 1674
            .|..:....:|             :|.||....|....      :::||..|...|      :.|
Human  1179 RFVHSKEKLRKGYLFLKISDQQFFSEPQLINIQAFSTQAPYVLRNEVLHISRGERA------TIT 1237

  Fly  1675 TSRTNIR 1681
            |...:||
Human  1238 TQMLDIR 1244

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fur2NP_727963.1 S8_pro-domain 242..318 CDD:465126
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 375..674 CDD:173789
P_proprotein 761..849 CDD:460225
GF_recep_IV 970..1073 CDD:464344 32/121 (26%)
VSP 1020..1379 CDD:146106 129/393 (33%)
FU 1401..1444 CDD:214589 15/42 (36%)
FRAS1NP_079350.5 VWC 28..87 CDD:214564
VWC 95..152 CDD:278520
VWC 159..216 CDD:278520
VWC 221..278 CDD:278520
VWC 285..342 CDD:214564
VWC 367..416 CDD:214564
VSP 396..>673 CDD:146106 71/234 (30%)
FU 1 409..460 4/13 (31%)
FU 2 462..505 10/45 (22%)
FU 3 507..553 15/48 (31%)
FU 4 555..599 15/43 (35%)
FU 5 602..647 17/44 (39%)
FU 6 649..705 15/61 (25%)
VSP 691..1060 CDD:146106 107/376 (28%)
FU 7 708..753 17/44 (39%)
FU 8 755..800 17/45 (38%)
FU 9 803..852 16/48 (33%)
FU 10 854..900 14/45 (31%)
FU 11 903..948 4/44 (9%)
FU 12 952..997 15/46 (33%)
FU 13 999..1042 11/42 (26%)
FU 14 1046..1089 9/53 (17%)
FU 1046..1087 CDD:214589 8/51 (16%)
Cadherin_3 1102..1198 CDD:465048 21/102 (21%)
CSPG 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1102..1197 21/101 (21%)
Cadherin_3 1203..1310 CDD:465048 12/48 (25%)
CSPG 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1217..1308 8/34 (24%)
Cadherin_3 1314..1438 CDD:465048
CSPG 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1329..1438
Cadherin_3 1446..1574 CDD:465048
CSPG 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1463..1559
Cadherin_3 1577..1691 CDD:465048
CSPG 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1595..1689
Cadherin_3 1699..1811 CDD:465048
CSPG 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1710..1810
Cadherin_3 1816..1938 CDD:465048
CSPG 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1833..1936
Cadherin_3 1941..2059 CDD:465048
CSPG 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 1957..2057
Cadherin_3 2073..2179 CDD:465048
CSPG 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2078..2177
Cadherin_3 2183..2293 CDD:465048
CSPG 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2199..2291
Cadherin_3 2297..2406 CDD:465048
CSPG 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2311..2404
Cadherin_3 2425..2537 CDD:465048
CSPG 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201 2439..2536
caca <2553..>2803 CDD:273296
Calx_beta 2555..2650 CDD:197594
Calx-beta 2798..2894 CDD:413355
caca <2907..>3134 CDD:273296
Blue background indicates that the domain is not in the aligned region.

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