DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and pcsk6

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	XP_021333790.1	Gene:	pcsk6 / 794305	ZFINID:	ZDB-GENE-100908-1	Length:	869	Species:	Danio rerio

Alignment Length:	1050	Identity:	358/1050 - (34%)
Similarity:	472/1050 - (44%)	Gaps:	247/1050 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 IYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSEN 302
            :|||.:||.||.|...||.:|:|:||.|.||||.|:::|.|.|..|.:||..::|.....:..:.
Zfish    46 VYTNHWAVRIPGGAGQADELASKYGFTNLGQIGGLEHHYHFHHRRVVRRSTFATRGAHSFIHMDP 110

  Fly   303 EVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYR 367
            :|.|.|||..|.|.||                                         |:     |
Zfish   111 KVVWAQQQVVKTRVKR-----------------------------------------HA-----R 129

  Fly   368 DVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGV--VVSILDDGIQTNHPDL 430
            ..|:|..|.||.:...||:||:                   |....|  |||:|...|   |.::
Zfish   130 SDSNHISFNDPKWSNMWYIVSR-------------------YFTHSVLYVVSVLSLLI---HLEI 172

  Fly   431 AQNYDPEASFDINGNDSDPTPQDNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK 495
            .                               ||.....|..:..         .:.|||||||.
Zfish   173 T-------------------------------CATTDLIVFLDEL---------FLQGVRMLDGD 197

  Fly   496 VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGN 560
            |.|||||::|.:.|.::|||||||||:|||.|||||||||::||..|...||:|.||||||||||
Zfish   198 VTDVVEAKSLGIRPDYVDIYSASWGPDDDGKTVDGPGPLAKQAFELGSKKGRKGLGSIFVWASGN 262

  Fly   561 GGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGS 625
            |||..|.|:||||||||:|:||||:|:.|.||||||.|||||||||||| ..:|:.:.|.|:
Zfish   263 GGRQGDHCSCDGYTNSIYTISISSSTENGNKPWYLEVCSSTLATTYSSG-EFYDRKIVTTDL--- 323

  Fly   626 LRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNGVK 690
               ...||..|||||.|||:.||:.||||||||.:||||:|:|:|.|||.|.| |.|.|..|...
Zfish   324 ---RQRCTDGHTGTSVSAPMVAGVIALALEANPLITWRDVQHLLVKTSRQAHL-KANDWKTNAAG 384

  Fly   691 RKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGCAGTI 755
            .|.||.:|:||:||.|||..|::|.:||.||||....:...|.|...  ..|:..:..|||....
Zfish   385 HKVSHLYGFGLVDAEAMVVEAKKWRNVPAQHICSKTSDRRTRYIRAE--QKLNASISSNGCRDQS 447

  Fly   756 NE-VRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHFWGEK 819
            .: |.:||||..|:.:....||:|.|.|.||.||.|.||.:|..|.....|.:|.|::||.||||
Zfish   448 EQTVVFLEHVVVRVLIVHPRRGDLEINLISPSGTRSQLLAQRLFDNSNEGFRNWEFMTVHCWGEK 512

  Fly   820 AEGRWTLQVINGGRRRVNQPGILSK---WQLIFYGTSTQPMRLKSELLNSSPQLRSPSSSNPFLF 881
            |||.|||: |:....::..|.:|.|   |.||.:|||..|.:.:|...:.|..|..|.:......
Zfish   513 AEGTWTLE-ISDSPSQLRNPEVLGKLKEWTLILHGTSEDPQQSQSSQQSRSRTLDLPIAGREMKS 576

  Fly   882 PSASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQNVTAAIAGGSSAESLGF 946
            |.|     |.:|                          |......:||
Zfish   577 PEA-----PEHE--------------------------EQEEEEYNGQ----------------- 593

  Fly   947 TASAAQLVAAPETRDGDKKILHSCDAECDSSGCYGRGPTQCVACSHYRLDN-----TCVSRCPPR 1006
                                   |..||...||.|.....|:.|.|:.|.|     ||||.||..
Zfish   594 -----------------------CHPECGDQGCDGPDADHCLNCIHFSLGNLKTGRTCVSHCPLG 635

  Fly  1007 SF-PNQVGICWPCHDTCETCAGAGPDSCLTCAPAHLHVIDLAVCLQFCPDGYFENSRNRTCVPCE 1070
            .| .:....|..|...||.|.|.|...|.:|............|::.||.|.|.:...|.||.|.
Zfish   636 FFEDSDARRCRRCSRGCEKCVGRGTSDCRSCRRGFYFNSKENTCVEICPTGSFHDDSQRRCVKCH 700

  Fly  1071 PNCASCQDHPEYCTSCDHHLVMHEHKCYSACPLDT-YETEDNKCAFCHSTCATCNGPTDQDCITC 1134
            .||..|....:.||:|.:...:....|...|...| :..|:.||:.||.:|:||.||..::||.|
Zfish   701 ENCLKCLRDADRCTACKNGFSLAGMTCVPECANGTFFNLEEMKCSPCHISCSTCTGPGQEECIQC 765

  Fly  1135 RSSRYAWQNKCLISCPDGFYADK-----KRLECMPCQEGCKTCTSNGV-CSECLQNWTLNKRDKC 1193
            .......:.:|:.||..|:|:.:     :|: |..|:|.|.:|...|. |::|...::|..| .|
Zfish   766 AQGFLQQEWRCVRSCAPGYYSGEAAGFTQRM-CRKCEENCLSCQGPGTSCTQCKDGYSLVSR-TC 828

  Fly  1194 IVSGSEGCSESEFYSQVEGQCRPCHASCGSCNGPADTSCTSCPPNRLLEQSRCVSGCREGFFVEA 1258
            ||:                         .:||...:..|.....|||.|:......|
Zfish   829 IVN-------------------------ATCNNADEVFCEMVKSNRLCEKKLFRQFC-------- 860

  Fly  1259 GSLCSPCLHT 1268
               |..||.|
Zfish   861 ---CRTCLMT 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	31/75 (41%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	139/300 (46%)
		Peptidase_S8	411..700	CDD:278510	143/290 (49%)
		P_proprotein	761..849	CDD:279782	40/90 (44%)
		Furin-like	966..1126	CDD:279142	53/166 (32%)
		FU	970..1013	CDD:238021	18/48 (38%)
		FU	1017..1067	CDD:238021	14/49 (29%)
		FU	1063..1106	CDD:214589	13/43 (30%)
		GF_recep_IV	1068..1232	CDD:291509	44/170 (26%)
		FU	1116..1163	CDD:238021	16/51 (31%)
		FU	1211..1255	CDD:214589	8/43 (19%)
		FU	1259..1301	CDD:214589	3/9 (33%)
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
pcsk6	XP_021333790.1	Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	35..369	CDD:173789	179/437 (41%)
		P_proprotein	454..544	CDD:307572	40/90 (44%)
		FU	594..763	CDD:320742	55/168 (33%)
		FU	743..785	CDD:214589	16/41 (39%)
		FU	795..829	CDD:214589	11/35 (31%)
		PLAC	841..864	CDD:312271	7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7406
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820