Protein Alignment Fur2 and pcsk6

DIOPT Version :10

• Sequence 1: NP_727963.1
• Gene: Fur2 / 32604
• FlyBaseID: FBgn0004598
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: XP_073764148.1
• Gene: pcsk6 / 794305
• ZFINID: ZDB-GENE-100908-1
• Length: 931
• Species: Danio rerio
• Alignment Length: 1050
• Identity: 407/1050 - (38%)
• Similarity: 531/1050 - (50%)
• Gaps: 185/1050 - (17%)

  Fly   238 IYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSEN 302
            :|||.:||.||.|...||.:|:|:||.|.||||.|:::|.|.|..|.:||..::|.....:..:.
Zfish    46 VYTNHWAVRIPGGAGQADELASKYGFTNLGQIGGLEHHYHFHHRRVVRRSTFATRGAHSFIHMDP 110

  Fly   303 EVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYR 367
            :|.|.|||..|.|.||                                         |:     |
Zfish   111 KVVWAQQQVVKTRVKR-----------------------------------------HA-----R 129

  Fly   368 DVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQ 432
            ..|:|..|.||.:...||:...:..::...:||:..|||:||||:.||::||||||:.|||||||
Zfish   130 SDSNHISFNDPKWSNMWYIHCSDKNSRCRSEMNILGAWQRGYTGRNVVITILDDGIERNHPDLAQ 194

  Fly   433 NYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK 495
            |||..||:|:||||.||||:  ...:|||||||||||||.|.|:.|.||:||||.|||||||||.
Zfish   195 NYDQLASYDVNGNDYDPTPRYDATNENKHGTRCAGEVAAAANNSHCIVGIAYNARIGGVRMLDGD 259

  Fly   496 VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGN 560
            |.|||||::|.:.|.::|||||||||:|||.|||||||||::||..|...||:|.||||||||||
Zfish   260 VTDVVEAKSLGIRPDYVDIYSASWGPDDDGKTVDGPGPLAKQAFELGSKKGRKGLGSIFVWASGN 324

  Fly   561 GGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGS 625
            |||..|.|:||||||||:|:||||:|:.|.||||||.|||||||||||| ..:|:.:.|.|:
Zfish   325 GGRQGDHCSCDGYTNSIYTISISSSTENGNKPWYLEVCSSTLATTYSSG-EFYDRKIVTTDL--- 385

  Fly   626 LRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNGVK 690
               ...||..|||||.|||:.||:.||||||||.:||||:|:|:|.|||.|.| |.|.|..|...
Zfish   386 ---RQRCTDGHTGTSVSAPMVAGVIALALEANPLITWRDVQHLLVKTSRQAHL-KANDWKTNAAG 446

  Fly   691 RKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGCAGTI 755
            .|.||.:|:||:||.|||..|::|.:||.||||....:...|.|...  ..|:..:..|||....
Zfish   447 HKVSHLYGFGLVDAEAMVVEAKKWRNVPAQHICSKTSDRRTRYIRAE--QKLNASISSNGCRDQS 509

  Fly   756 NE-VRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHFWGEK 819
            .: |.:||||..|:.:....||:|.|.|.||.||.|.||.:|..|.....|.:|.|::||.||||
Zfish   510 EQTVVFLEHVVVRVLIVHPRRGDLEINLISPSGTRSQLLAQRLFDNSNEGFRNWEFMTVHCWGEK 574

  Fly   820 AEGRWTLQVINGGRRRVNQPGILSK---WQLIFYGTSTQPMRLKSELLNSSPQLRSPSSSNPFLF 881
            |||.|||: |:....::..|.:|.|   |.||.:|||..|.:.:|...:.|..|..|.:......
Zfish   575 AEGTWTLE-ISDSPSQLRNPEVLGKLKEWTLILHGTSEDPQQSQSSQQSRSRTLDLPIAGREMKS 638

  Fly   882 PSASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQNVTAAIAGGSSAESLGF 946
            |.|     |.:|                          |......:||
Zfish   639 PEA-----PEHE--------------------------EQEEEEYNGQ----------------- 655

  Fly   947 TASAAQLVAAPETRDGDKKILHSCDAECDSSGCYGRGPTQCVACSHYRLDN-----TCVSRCPPR 1006
                                   |..||...||.|.....|:.|.|:.|.|     ||||.||..
Zfish   656 -----------------------CHPECGDQGCDGPDADHCLNCIHFSLGNLKTGRTCVSHCPLG 697

  Fly  1007 SF-PNQVGICWPCHDTCETCAGAGPDSCLTCAPAHLHVIDLAVCLQFCPDGYFENSRNRTCVPCE 1070
            .| .:....|..|...||.|.|.|...|.:|............|::.||.|.|.:...|.||.|.
Zfish   698 FFEDSDARRCRRCSRGCEKCVGRGTSDCRSCRRGFYFNSKENTCVEICPTGSFHDDSQRRCVKCH 762

  Fly  1071 PNCASCQDHPEYCTSCDHHLVMHEHKCYSACPLDT-YETEDNKCAFCHSTCATCNGPTDQDCITC 1134
            .||..|....:.||:|.:...:....|...|...| :..|:.||:.||.:|:||.||..::||.|
Zfish   763 ENCLKCLRDADRCTACKNGFSLAGMTCVPECANGTFFNLEEMKCSPCHISCSTCTGPGQEECIQC 827

  Fly  1135 RSSRYAWQNKCLISCPDGFYADK-----KRLECMPCQEGCKTCTSNGV-CSECLQNWTLNKRDKC 1193
            .......:.:|:.||..|:|:.:     :|: |..|:|.|.:|...|. |::|...::|..| .|
Zfish   828 AQGFLQQEWRCVRSCAPGYYSGEAAGFTQRM-CRKCEENCLSCQGPGTSCTQCKDGYSLVSR-TC 890

  Fly  1194 IVSGSEGCSESEFYSQVEGQCRPCHASCGSCNGPADTSCTSCPPNRLLEQSRCVSGCREGFFVEA 1258
            ||:                         .:||...:..|.....|||.|:......|
Zfish   891 IVN-------------------------ATCNNADEVFCEMVKSNRLCEKKLFRQFC-------- 922

  Fly  1259 GSLCSPCLHT 1268
               |..||.|
Zfish   923 ---CRTCLMT 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:465126	31/75 (41%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	375..674	CDD:173789	188/300 (63%)
		P_proprotein	761..849	CDD:460225	40/90 (44%)
		GF_recep_IV	970..1073	CDD:464344	36/108 (33%)
		VSP	1020..1379	CDD:146106	68/255 (27%)
		FU	1401..1444	CDD:214589
pcsk6	XP_073764148.1	None