DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fur2 and pcsk5

DIOPT Version :9

Sequence 1:NP_727963.1 Gene:Fur2 / 32604 FlyBaseID:FBgn0004598 Length:1682 Species:Drosophila melanogaster
Sequence 2:XP_031746755.1 Gene:pcsk5 / 779961 XenbaseID:XB-GENE-959596 Length:1850 Species:Xenopus tropicalis


Alignment Length:1922 Identity:578/1922 - (30%)
Similarity:754/1922 - (39%) Gaps:659/1922 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   238 IYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSEN 302
            ::||.:||.|..|:..|:.||:|:|:.|.||||:|.:||.|.|....|||:.|||.....:..|.
 Frog    30 MFTNHWAVRIAGGETEANRIASKYGYTNMGQIGALQDYYHFFHSKTIKRSILSSRGTHSFISMEP 94

  Fly   303 EVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYR 367
            :|:|:|||..|.|.|||        |.|.|                                   
 Frog    95 KVEWIQQQVVKKRIKRD--------YKPTN----------------------------------- 116

  Fly   368 DVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQ 432
             ..|.| |.||.:...||:...........|||:..||::|||||.|||:||||||:.|||||.|
 Frog   117 -TQSTF-FNDPKWPSMWYMHCSENVHHCQSDMNIVGAWKRGYTGKNVVVTILDDGIERNHPDLMQ 179

  Fly   433 NYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK 495
            |||.:||.||||||.||.|:  .:.:|||||||||||||.|.|:.|.||:|:||.|||||||||.
 Frog   180 NYDAQASTDINGNDFDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGD 244

  Fly   496 VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGN 560
            |.|:|||::|||||.|:.||||||||:|||.|||||..|||.||..|:.:||:|.||::||||||
 Frog   245 VTDMVEAKSLSLNPQHVHIYSASWGPDDDGKTVDGPASLAREAFENGIRTGRRGFGSVYVWASGN 309

  Fly   561 GGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGS 625
            |||..|.|:||||||||:|:||||.|::|.||||||||:|||||||||| ..:|:.|.|.|:   
 Frog   310 GGRSRDHCSCDGYTNSIYTISISSTTESGKKPWYLEECASTLATTYSSG-ESYDRKVITTDL--- 370

  Fly   626 LRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNGVK 690
               ...||..|||||||||:||||.||||||||.|||||:|:::|.|||...|...: |..|...
 Frog   371 ---RQRCTDSHTGTSASAPMAAGIIALALEANPFLTWRDVQHIIVRTSRQRHLNAPD-WKTNAAG 431

  Fly   691 RKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKI-----DGAYGSTLSTHMDVNG 750
            .|.||.:|:|||||.|||..||:||:||.||||   ..|.||:|     |....|...    ..|
 Frog   432 YKVSHLYGFGLMDAEAMVIEAEKWTTVPAQHIC---VENTDRQIKTIRPDNVVRSVYK----ATG 489

  Fly   751 CAGTIN-EVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVH 814
            ||...| .|.|||||..|:::....||:|.|.||||.||.|.||..|..|.....|.:|.|::.|
 Frog   490 CADNTNHHVVYLEHVVVRVSITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTTH 554

  Fly   815 FWGEKAEGRWTLQVIN--GGRRRVNQPGILSKWQLIFYGTSTQPMR-----LKSELLNSSPQLRS 872
            .|||:|.|.|||::.:  ...|....||.|.:|.|:.||||..|..     .|.|.:.||| :..
 Frog   555 CWGERASGDWTLEIYDTPSQLRNFKTPGKLKEWSLVLYGTSVHPYSPRNDVPKVERVRSSP-IDE 618

  Fly   873 PS---SSNPFLFP---SASNIGQPANEGGNFNTDSFASYLNYQN--------------------- 910
            ||   |.:.:..|   ..||:|.. ..|.:..||....|...:|                     
 Frog   619 PSEDYSMDDYTGPCDVECSNVGCD-GPGPDHCTDCLHFYYKAKNNTRICVSDCPAGHYLADKKRC 682

  Fly   911 ------IFSSAGSDPEPATATLDG----------------------------------------Q 929
                  ..|..||..:..||...|                                        |
 Frog   683 KKCFLHCESCVGSRSDQCTACKPGYYLNEESNSCIINCPEGFYLNENKVLCRKCNENCKSCTSEQ 747

  Fly   930 NVT-----AAIAGGSSAESL--GFTASAAQLVAAPETR-----------------DG----DKKI 966
            ..|     .::.|...|.|.  |...||.:....|..|                 ||    |.|.
 Frog   748 TCTECKPGLSLQGSKCAMSCEDGKYYSALKKECDPCHRSCATCSGPGIDNCINCTDGTLFEDGKC 812

  Fly   967 LH--------------------SCDAEC------------------------------------- 974
            :|                    .|||.|                                     
 Frog   813 VHMCSSGYYLTQSKTNAYKICKKCDASCLTCSGPGDRNCTSCLDNYVLESSVCVVGTICKDGEYI 877

  Fly   975 DSSG-----------CYGRGPTQCVACSHYRL-DN-TCVSRCPPRSFPNQVGICWPCHDTCETCA 1026
            |.:|           |.|.|...|:.||..|: || .||.|||...|.:. ..|..||.||..|.
 Frog   878 DETGRCKFCDASCAKCIGPGKYNCIGCSQTRIFDNKQCVLRCPSGKFESN-RQCHQCHHTCHECN 941

  Fly  1027 GAGPDSCLTCAPAHLHVIDL---AVCLQFCPDGYFENSRNRTCVPCEPNCASC------------ 1076
            |:.||.|.:|.|....:...   ..|.:.||.|::  :...||:.|.|||..|            
 Frog   942 GSEPDECTSCGPDKNEITRFLYNGECREGCPQGHY--AAESTCIQCPPNCDLCDRDSTCIRCLEG 1004

  Fly  1077 ------------------QD-------------------HPEYCTSCDHHLVMHEHKCYSACPLD 1104
                              :|                   .|..|.||.....|:|..||..||.:
 Frog  1005 FHLDKGVCQKRACPEGETEDMDTGNCVACTIGCSKCYTYDPSSCISCIKGYYMYETYCYDVCPEN 1069

  Fly  1105 TYETE-----------------------------------------------DNKCAFCHSTCAT 1122
            ||..:                                               |.:|..|:..|.:
 Frog  1070 TYSNDSLMSCIDCAETCFSCTEDQCIECEEGFYLLEGECVTDCGPGFYSDDIDKECDICYRACDS 1134

  Fly  1123 CNGPTDQDCITCRSS-------------------------------------------------- 1137
            |.||...:|.:|:.:                                                  
 Frog  1135 CTGPDYDECTSCKDTYTLLQGKCMPYKNSPEEGTFVNREGKSQPCNSACKTCNGSASACTSCKQG 1199

  Fly  1138 ----------------------------------------------RYAWQNKCLISCPDGFY-- 1154
                                                          .|..:.||...||.||:  
 Frog  1200 TYLHDRSCIPECPNGFFENEKDGRCEKCTVGCERCTEANVCLQCLVGYKHEGKCYKQCPSGFFGH 1264

  Fly  1155 ------------------------ADKKRL------------------ECMPCQEGCKTCTSNGV 1177
                                    :|.|.|                  ||..|...||||||...
 Frog  1265 TGVCEKCSSDCKTCKDNADYCLSCSDPKLLEQARCTNVCSERYTAINGECKHCSHNCKTCTSLDT 1329

  Fly  1178 CSECLQNWTLNKRDKCI-----------------------VSG-----SEGCSESEF-------- 1206
            ||||:..:.|.. .||:                       .||     .|.||...|        
 Frog  1330 CSECMHGYFLYD-GKCVEYCPDGYYENNGNCFQCDPMCAKCSGPDADDCEECSSKSFFLYNGECF 1393

  Fly  1207 ---------------------------------------------------------YSQVEGQC 1214
                                                                     |......|
 Frog  1394 GTCPEGTYYEPSTKDCQDCDTSCKTCSSFTTCDSCRDNLVKNKEGFCVTYKDCSLNQYQDEHKNC 1458

  Fly  1215 RPCHASCGSCNGPADTSCTSCPPNRLLEQSRCVSGCREGFFVEAGS-LCSPCLHTCSQCVSR--T 1276
            .|||..|..|.|..:..|.:||.|..|..|.|.:.|.||::.|... .|:||..||..|..:  |
 Frog  1459 HPCHKKCSRCMGATEHHCLNCPSNHFLLNSTCFAKCPEGYYTEEEEHRCAPCHSTCLTCFGKRST 1523

  Fly  1277 NCSNCSKGLELQNGECRTTCADGYYSDRGI--CAKCYLSCHTCSGPRRNQCVQCPAGWQL--AAG 1337
            :|.:|........|.|...|..|||::...  |.||::||..|:||..:.|:.|...:.|  |..
 Frog  1524 HCLSCKTDWYSLGGACMQNCIKGYYAENSTSKCEKCHMSCEECTGPEASNCLSCHKDFFLMRAKQ 1588

  Fly  1338 ECHPECPEGFYKSDF--GCQKCHHYCKTCNDAGPLACTSCPPHSMLDGGLC-MECLSSQY--YDT 1397
            :|...|||.:|:...  .|::||..||||...|.||||||.....|.|.:| .|||:.::  .:.
 Frog  1589 QCVSSCPEQYYEDHTVRRCERCHPTCKTCTSFGALACTSCVSSYQLFGHICNSECLAGEFKAKED 1653

  Fly  1398 TSATCKTCHDSCRSCFGPGQFSCKGCVPP--LHLDQLNSQCVSCCQNQTLAEKTSSAACCNCDGE 1460
            ...:|:.||:||..|.|||..:|..|...  |::|:  .:||.||.. .|||   .|.||:|...
 Frog  1654 PDQSCEKCHESCIECKGPGPLNCTVCPASQVLYVDE--GRCVHCCHG-NLAE---VAECCDCSVT 1712

  Fly  1461 TGEC-----KATSTGGKRRTVVGSGSAYKSSESKHGSFENDGNAREFVLRLDSPLTAITAIAVAI 1520
            ..||     ..|.:.||::|.                                 |...|:|    
 Frog  1713 LDECILLKGLLTESEGKQKTA---------------------------------LFITTSI---- 1740

  Fly  1521 CLLIITIFSIIFAVLQRNSNHVSRNSVRYRKIANTS------SGRRKNLSAKPTSDARFIFNIGE 1579
             ||:::|.:|:....:..:...|.:...|.|:.:.:      .||.:..|.:  .|....::..|
 Frog  1741 -LLVLSIGAILVYWKRSKAKVKSVSKAGYEKLPDQTKSFQSFKGRERTSSFQ--RDQVIEYHDRE 1802

  Fly  1580 DDDTDGDNSDDEL----DGNVGTDINNRIVYDRKGND 1612
            ::|.|.|:.||.:    ||.|.......::.|.:.:|
 Frog  1803 EEDEDEDDDDDIVYMGQDGTVYRKFKYGLLEDEEEDD 1839

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fur2NP_727963.1 S8_pro-domain 242..318 CDD:293079 33/75 (44%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-like 375..674 CDD:173789 191/300 (64%)
Peptidase_S8 411..700 CDD:278510 187/290 (64%)
P_proprotein 761..849 CDD:279782 38/89 (43%)
Furin-like 966..1126 CDD:279142 63/328 (19%)
FU 970..1013 CDD:238021 21/92 (23%)
FU 1017..1067 CDD:238021 16/52 (31%)
FU 1063..1106 CDD:214589 18/91 (20%)
GF_recep_IV 1068..1232 CDD:291509 67/492 (14%)
FU 1116..1163 CDD:238021 18/186 (10%)
FU 1211..1255 CDD:214589 17/43 (40%)
FU 1259..1301 CDD:214589 13/44 (30%)
FU 1304..1348 CDD:214589 16/47 (34%)
FU 1356..1403 CDD:238021 19/49 (39%)
FU 1401..1444 CDD:214589 17/44 (39%)
pcsk5XP_031746755.1 S8_pro-domain 34..110 CDD:406785 33/75 (44%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 122..416 CDD:173789 191/300 (64%)
P_proprotein 501..591 CDD:396185 38/89 (43%)
GF_recep_IV 631..740 CDD:405525 15/109 (14%)
VSP 689..1033 CDD:146106 66/346 (19%)
FU 1027..1071 CDD:214589 10/43 (23%)
FU 1082..1125 CDD:238021 1/42 (2%)
FU 1122..1159 CDD:214589 9/36 (25%)
FU 1178..1225 CDD:238021 0/46 (0%)
VSP 1240..1577 CDD:146106 75/337 (22%)
GF_recep_IV 1517..1614 CDD:405525 30/96 (31%)
FU 1605..1648 CDD:214589 20/42 (48%)
FU 1655..1696 CDD:214589 15/42 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 85 1.000 Domainoid score I8065
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H21244
Inparanoid 1 1.050 770 1.000 Inparanoid score I531
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D311719at33208
OrthoFinder 1 1.000 - - FOG0000204
OrthoInspector 1 1.000 - - otm48510
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4005
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.060

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