DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and pcsk5a

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	XP_003198725.3	Gene:	pcsk5a / 571235	ZFINID:	ZDB-GENE-060531-130	Length:	1867	Species:	Danio rerio

Alignment Length:	1385	Identity:	489/1385 - (35%)
Similarity:	651/1385 - (47%)	Gaps:	309/1385 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 IYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSEN 302
            :|||.:||.|..|.:.||:||.|:||:|.||||.|.::|.|||..:.|||...|:.:...:..|.
Zfish    24 LYTNRWAVKITGGPEAADLIAEKYGFVNMGQIGGLVDHYQFQHSGIIKRSTIKSKGNHSLITMET 88

  Fly   303 EVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYR 367
            :|:|:|||..:.|.|                                             |.|..
Zfish    89 KVEWIQQQMVQKRVK---------------------------------------------RTETM 108

  Fly   368 DVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQ 432
            |.:....|.||.:...||:...:...   .|||:..||::||||||||||||||||:..||||.|
Zfish   109 DQTHDGSFNDPKWDSMWYIHCDHNCL---TDMNIQAAWRRGYTGKGVVVSILDDGIERQHPDLKQ 170

  Fly   433 NYDPEASFDINGNDSDPTPQDN--GDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK 495
            |||..||:|:||||.||||:.:  .:|||||||||.|||.|.|:.|.||:||||.|||||||||.
Zfish   171 NYDARASYDVNGNDPDPTPRYDVTNENKHGTRCAGVVAASANNSLCIVGIAYNAKIGGVRMLDGD 235

  Fly   496 VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGN 560
            :.|:||||:|:|...:|||||:||||:|||.||||||||||.|...|:..||:|:||||||||||
Zfish   236 MTDMVEAQSLNLRQQYIDIYSSSWGPDDDGRTVDGPGPLARLALENGIRKGRKGRGSIFVWASGN 300

  Fly   561 GGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGS 625
            ||:..|.|:||||||||:|:|:.|.||:|.||||||||||||||||||| ..|...|.|.|:
Zfish   301 GGQSQDHCSCDGYTNSIYTISVGSTTQSGRKPWYLEECSSTLATTYSSG-DSHSPGVVTTDL--- 361

  Fly   626 LRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNGVK 690
               ...||.||:|||||||:||||.||.|||||.|||||:|:::|.||....|...: |..||..
Zfish   362 ---RQRCTDEHSGTSASAPMAAGIIALTLEANPALTWRDIQHIIVKTSSRGHLSASD-WQSNGAG 422

  Fly   691 RKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGC-AGT 754
            ...||.:|:||::|.|||..||.|..||.||||:.......|.|...  ..|.:.:..:|| |..
Zfish   423 YDVSHLYGFGLLNAEAMVKNAETWKQVPSQHICEENIGQNARIISPE--RVLRSVLKSSGCSAQR 485

  Fly   755 INEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHFWGEK 819
            :..|.|||||..|:|:....||:|.|.||||.||||.||..||.|.....|..|.|::.|.|||:
Zfish   486 LQRVVYLEHVIVRVTITHPHRGDLSITLTSPSGTTSQLLANRPNDHSSEGFIKWEFMTTHCWGER 550

  Fly   820 AEGRWTLQVIN--GGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSSPQLRSPSSSNPFLFP 882
            :.|.|.|.:.:  ..:|.....|.|.:|.|:.|||||.|
Zfish   551 SAGDWILDIRDTPSPQRNTRLQGKLVEWSLVLYGTSTHP-------------------------- 589

  Fly   883 SASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQN-VTAAIAGGSSAESLGF 946
                                  |:.::          :|.:|.|..:: :|....|
Zfish   590 ----------------------YIRHE----------QPRSAQLPSEDEITEEYNG--------- 613

  Fly   947 TASAAQLVAAPETRDGDKKILHSCDAECDSSGCYGRGPTQCVACSHYRL-----DNTCVSRCPPR 1006
                                  |||.||...||.|.||.|||:|.:..|     ..||||.||..
Zfish   614 ----------------------SCDPECSEDGCEGPGPHQCVSCLNLFLKFKNNTRTCVSECPSG 656

  Fly  1007 SFPNQVGICWPCHDTCETCAGAGPDSCLTCAPA-HLHVIDLAVCLQFCPDGYFENSRNRTCVPCE 1070
            .:.::.. |..|:.:|::|.|:..|.|.||... ||:. :...|:..|.||||.......|..|.
Zfish   657 YWGDKKR-CKKCYSSCKSCLGSRSDQCTTCKSGYHLNE-EKNNCVTSCEDGYFLYHEENMCRKCN 719

  Fly  1071 -PNCASCQDHPEYCTSCDHHLVMHEHKCYSACPLDTYETE-DNKCAFCHSTCATCNGPTDQDCIT 1133
             .||..|.. ...||.|.....:..::|..:|.:.:|.:| ::.|..||..||||.....:.|..
Zfish   720 IENCMKCTS-ASICTECSEGTSLVGNRCQKSCEVGSYYSEPEDSCEACHPACATCAAAGLESCNR 783

  Fly  1134 CRSSRYAWQN-KCLISCPDGFYADKKRLE----CMPCQEGCKTCT--SNGVCSECLQNWTLNKRD 1191
            | :..|..:| :|:.||..||||:::..:    |..|...|..|.  :...||||:...:| :..
Zfish   784 C-AEGYLMENWRCVSSCSQGFYAEQQNSDNQSTCKRCDASCLACVGPTKTNCSECVDGHSL-QDG 846

  Fly  1192 KCIVSGSEGCSESEFYSQVEGQCRPCHASCGSCNGPADTSCTSCPPNRLLEQSRCVSGCREGFFV 1256
            .|::  |..|.:.| |....|:|:.||.||..|.||....|.||....||:..:||..|..|.:
Zfish   847 VCVL--SHNCGDGE-YQDESGECQSCHVSCQKCKGPQSEDCLSCFSTHLLDYGQCVISCSNGKY- 907

  Fly  1257 EAGSLCSPCLHTCSQCV--SRTNCSNCSK---GLE--LQNGECRTT------------------- 1295
            .:|..|..|.|||:|||  ..:||::|..   |::  |.:|||...
Zfish   908 PSGGQCHLCDHTCAQCVDDGPSNCTSCDTDKFGVDRYLYHGECVDACPKAHFHTVLKACEPCPSY 972

  Fly  1296 ------------CADGYYSDRGICAK--------------------------------------- 1309
                        |.|.:|.:.|:|.|
Zfish   973 CKLCSSATHCIKCEDSFYVNNGVCNKLECGEGEVEDPEYDDCMPCEEGCHKCVLYNPKHCLSCIN 1037

  Fly  1310 --------CYLSC-----------------HTCSGPRRNQCVQCPAGWQLAAGECHPECPEGFYK 1349
                    ||.:|                 |.|.....::|..|.|.:.::.|:|..|||:|||.
Zfish  1038 GYYRFEESCYKNCPSKTYPVEETMSCVSCEHDCVNCDEDECSWCEADFFISNGKCVRECPDGFYN 1102

  Fly  1350 SDFG--CQKCHHYCKTCNDAGPLACTSCPPHSMLDGGLCM---ECLSSQYYDTTSATCKTCHDSC 1409
            .:..  |::||..|:||:......|.||.....||.|.|:   :...:|.|.|....|:.||..|
Zfish  1103 DNESQECEECHSDCRTCSGPEDSDCESCSEGLTLDNGACVSEQDVCPAQMYLTDDGECEACHPLC 1167

  Fly  1410 RSCFGPGQFSCKGCVPPLHLDQLNSQCVSCCQNQTLAEK------TSSAACCNCDGE-------- 1460
            .||:|..:..|..||...:|:.  .|||:.|...:...|      |....|..|..|
Zfish  1168 ESCWGKMKNQCNTCVKGRYLNA--DQCVARCPVGSFGSKDSGHCETCPQGCAQCQDEQLCTRCQS 1230

  Fly  1461 ---------TGECKATSTGG 1471
                     .|:|....|.|
Zfish  1231 TRKNPLYLQAGQCVRKCTRG 1250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	32/75 (43%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	190/300 (63%)
		Peptidase_S8	411..700	CDD:278510	185/290 (64%)
		P_proprotein	761..849	CDD:279782	38/89 (43%)
		Furin-like	966..1126	CDD:279142	57/167 (34%)
		FU	970..1013	CDD:238021	20/47 (43%)
		FU	1017..1067	CDD:238021	16/50 (32%)
		FU	1063..1106	CDD:214589	10/43 (23%)
		GF_recep_IV	1068..1232	CDD:291509	52/172 (30%)
		FU	1116..1163	CDD:238021	17/51 (33%)
		FU	1211..1255	CDD:214589	18/43 (42%)
		FU	1259..1301	CDD:214589	19/79 (24%)
		FU	1304..1348	CDD:214589	17/107 (16%)
		FU	1356..1403	CDD:238021	15/49 (31%)
		FU	1401..1444	CDD:214589	15/42 (36%)
pcsk5a	XP_003198725.3	S8_pro-domain	29..104	CDD:318632	33/119 (28%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	116..406	CDD:173789	189/299 (63%)
		P_proprotein	492..582	CDD:307572	38/89 (43%)
		FU	615..726	CDD:320742	41/112 (37%)
		VSP	682..1073	CDD:333463	101/398 (25%)
		VSP	1019..>1277	CDD:333463	56/234 (24%)
		Furin-like_2	1274..1341	CDD:318185
		FU	1402..1448	CDD:238021
		FU	1453..1565	CDD:320742
		FU	1550..1599	CDD:238021
		FU	1596..1639	CDD:214589
		FU	1649..1686	CDD:214589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7406
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21244
Inparanoid	1	1.050	745	1.000	Inparanoid score	I565
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		otm25484
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4005
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.770