DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and furinb

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_001038574.2	Gene:	furinb / 566591	ZFINID:	ZDB-GENE-040901-2	Length:	823	Species:	Danio rerio

Alignment Length:	838	Identity:	367/838 - (43%)
Similarity:	446/838 - (53%)	Gaps:	201/838 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 IPEEAIYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGA 297
            |..:.||.|.:||:|..|.:.|:.||.||||::.||:  ..::|.|||..|.:|||.|.|.....
Zfish    25 ITGQGIYINTWAVHIEGGVEEAERIAQKHGFVSHGQV--FGDFYHFQHRGVVRRSLSSHRGVHVR 87

  Fly   298 LKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQ 362
            |.:|.:|.|.:||..|.|||||
Zfish    88 LHTEPQVLWAEQQIAKRRRKRD------------------------------------------- 109

  Fly   363 RMEYRDVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNH 427
                    .|....||.|.:||||.:.:.|     |:||..||.:|:||:||||:||||||:.:|
Zfish   110 --------IHMEPTDPKFPQQWYLYNPSHG-----DLNVKEAWAQGFTGRGVVVTILDDGIEKDH 161

  Fly   428 PDLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVR 490
            ||||:||||:||:|:|..|.||.|:  ...||:|||||||||||.|.|..|||||||||.|||||
Zfish   162 PDLAKNYDPDASYDVNDRDPDPQPRYTQLNDNRHGTRCAGEVAAAANNGVCGVGVAYNAKIGGVR 226

  Fly   491 MLDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFV 555
            ||||:|.||||||:||||..||.||||||||||||.|||||..||:.||:.|||.||.|.|||||
Zfish   227 MLDGEVTDVVEAQSLSLNSQHIHIYSASWGPEDDGKTVDGPAKLAKEAFLQGVTEGRSGLGSIFV 291

  Fly   556 WASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATV 620
            ||||||||..||||||||||||:||||||.||.|..|||.|.||||||||||||.. ::|.:.|.
Zfish   292 WASGNGGRERDSCNCDGYTNSIYTLSISSTTQYGSVPWYSEACSSTLATTYSSGNL-NEKQIVTT 355

  Fly   621 DMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWT 685
            |:...      ||..||||||||||||||.|||||||..|||||||:|||.|||||.| ..|.|.
Zfish   356 DLRKK------CTDSHTGTSASAPLAAGIIALALEANMNLTWRDMQHLVVRTSRPAHL-ITNDWR 413

  Fly   686 LNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNG 750
            .|||.|..||.:||||:||.|||:||:.|||:.|||.|......|.|.|.    :.|:....|..
Zfish   414 TNGVGRLVSHSYGYGLLDATAMVALAQNWTSMGPQHKCVINMLTEPRDIK----NHLTFSRSVEA 474

  Fly   751 CAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHF 815
            |:|..:.|..|||||.|:||.:..||||.:.|.||:||.||||..||:|.....|:||.|::.|.
Zfish   475 CSGQPDFVSSLEHVQARLTLSYNHRGNLAVHLISPLGTRSTLLAPRPQDNSAEGFNDWAFMTTHS 539

  Fly   816 WGEKAEGRWTLQVIN-GGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSSPQLRSPSSSNPF 879
            |.|...|.|||::.| .|   :|..|:||::.||.|||.                    ||:..
Zfish   540 WDEDPRGEWTLEIENVAG---LNDYGVLSQFTLILYGTG--------------------SSATD- 580

  Fly   880 LFPSASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQNVTAAIAGGSSAESL 944
              ||.|:..:|:|.                            :..|.|.|.:
Zfish   581 --PSVSDYTRPSNN----------------------------SCKTFDTQQI------------- 602

  Fly   945 GFTASAAQLVAAPETRDGDKKILHSCDAECDSSGCYGRGPTQCVACS-HYRLD-NTCVSRCPPR- 1006
                                                      |:.|| .:.|. ..||..|||.
Zfish   603 ------------------------------------------CIECSTGFSLFLQGCVKSCPPGF 625

  Fly  1007 -SFP-------------NQVGICWPCHDTCETCAGAGPDSCLTCAPAHLHVIDLAVCL 1050
             |.|             :.|..|.|||..|.||:|:|.:.||:| |.|.|::..: ||
Zfish   626 ISGPQVLNLSLDNWVEHSTVQACLPCHPACLTCSGSGENECLSC-PPHSHLVATS-CL 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	32/75 (43%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	203/300 (68%)
		Peptidase_S8	411..700	CDD:278510	202/290 (70%)
		P_proprotein	761..849	CDD:279782	42/88 (48%)
		Furin-like	966..1126	CDD:279142	29/102 (28%)
		FU	970..1013	CDD:238021	11/59 (19%)
		FU	1017..1067	CDD:238021	16/34 (47%)
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
furinb	NP_001038574.2	S8_pro-domain	34..108	CDD:293079	32/75 (43%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	114..403	CDD:173789	203/300 (68%)
		Peptidase_S8	145..428	CDD:278510	202/290 (70%)
		P_proprotein	485..571	CDD:279782	42/88 (48%)
		TNFRSF	606..>669	CDD:304602	22/62 (35%)
		FU	648..683	CDD:214589	17/36 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12123
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.720