DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur2 and furina

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_001038571.1	Gene:	furina / 566557	ZFINID:	ZDB-GENE-040901-1	Length:	806	Species:	Danio rerio

Alignment Length:	846	Identity:	368/846 - (43%)
Similarity:	446/846 - (52%)	Gaps:	205/846 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 EAIYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKS 300
            :.:|||.:||:|..|::.||.||.||.|:|.|.:  ..:||.|:|..|.||||...|.....|.:
Zfish    27 QKVYTNTWAVHIEGGEEEADRIARKHSFVNHGNV--FGDYYHFRHRTVVKRSLSEHRGTHIRLHT 89

  Fly   301 ENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRME 365
            |.:|.|.:||..|.|:|||..|:  ||
Zfish    90 EPQVMWAEQQVVKRRKKRDVYYE--PT-------------------------------------- 114

  Fly   366 YRDVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDL 430
                       ||.|.:||||.:     :|.||:||..||::|.||:|||||||||||:.|||||
Zfish   115 -----------DPKFAQQWYLYN-----QDHLDLNVKNAWKQGVTGQGVVVSILDDGIEKNHPDL 163

  Fly   431 AQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLD 493
            .|||||:||:|:|..|.||.|:  ...||:|||||||||||||.|:.|||||||||.||||||||
Zfish   164 VQNYDPDASYDVNDGDPDPQPRYTQLNDNRHGTRCAGEVAAVADNDICGVGVAYNARIGGVRMLD 228

  Fly   494 GKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWAS 558
            |:|.||||||:|||||.|||||||||||||||.|||||..||:.||..||..||.|:||||||||
Zfish   229 GEVTDVVEAQSLSLNPQHIDIYSASWGPEDDGKTVDGPAKLAKEAFQRGVIEGRGGRGSIFVWAS 293

  Fly   559 GNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMD 623
            |||||..||||||||||||:||||||:||.|..|||.|.||||||:|||||.. ::|.:.|.|:.
Zfish   294 GNGGRMKDSCNCDGYTNSIYTLSISSSTQNGNVPWYSEACSSTLASTYSSGGV-NEKQIVTTDLR 357

  Fly   624 GSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNG 688
            ..      ||..||||||||||||||.|||||||..|||||||:|||.||.||.| ..|.|.:||
Zfish   358 QK------CTDSHTGTSASAPLAAGIIALALEANKNLTWRDMQHLVVRTSNPAHL-TTNDWKING 415

  Fly   689 VKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGCAG 753
            |.|:.||.:||||:||||:|:||:.||:|.|||.|.....:|.|.|    ||.|..:..|:.|.|
Zfish   416 VGRRVSHSYGYGLLDAGAIVALAKNWTNVGPQHKCVLSLVSEPRNI----GSYLVINKTVDACTG 476

  Fly   754 TINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHFWGE 818
            ..|.|..|||||.::||.:..||||.|.|.||.||.||||..||.|.....|:||.|::.|.|.|
Zfish   477 MANFVSSLEHVQAQLTLSYNRRGNLAIYLISPQGTRSTLLPPRPHDYSSEGFNDWAFMTTHSWDE 541

  Fly   819 KAEGRWTLQVIN-GGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSSPQLRSPSSSNPFLFP 882
            ...|.|||::.| .|   .:..|.|:::.|:.|||
Zfish   542 DPRGEWTLEIKNVAG---TSDYGTLTQFTLVLYGT------------------------------ 573

  Fly   883 SASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQNVTAAIAGGSSAESLGFT 947
             ||::.:.:..|.:...||.....:...|
Zfish   574 -ASSLSRSSTAGSSQTADSSCKTYDLNQI------------------------------------ 601

  Fly   948 ASAAQLVAAPETRDGDKKILHSCDAECDSSGCYGRGPTQCVACS--HYRLDNTCVSRCP------ 1004
                                                   |..|:  .|.....||..||
Zfish   602 ---------------------------------------CTECNPGFYLYQKGCVRDCPAGFTEG 627

  Fly  1005 --PRSFPNQVG-----ICWPCHDTCETCAGAGPDSCLTCAPAHLHVIDL-AVCL------QFCPD 1055
              |....|::.     .|.|||..|.||:|.||..||:| |.|.|:..| ..||      :..||
Zfish   628 SRPTILNNELSSVLHPACLPCHSVCLTCSGTGPQDCLSC-PPHSHLGPLTGTCLHQNQIQRESPD 691

  Fly  1056 G 1056
            |
Zfish   692 G 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	31/75 (41%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	207/300 (69%)
		Peptidase_S8	411..700	CDD:278510	204/290 (70%)
		P_proprotein	761..849	CDD:279782	40/88 (45%)
		Furin-like	966..1126	CDD:279142	31/113 (27%)
		FU	970..1013	CDD:238021	9/52 (17%)
		FU	1017..1067	CDD:238021	21/47 (45%)
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
furina	NP_001038571.1	S8_pro-domain	33..107	CDD:293079	31/75 (41%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	113..401	CDD:173789	208/348 (60%)
		Peptidase_S8	144..427	CDD:278510	204/290 (70%)
		P_proprotein	484..570	CDD:279782	40/88 (45%)
		FU	590..624	CDD:214589	10/108 (9%)
		FU	645..682	CDD:214589	19/37 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12123
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720