DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fur2 and fras1

DIOPT Version :9

Sequence 1:NP_727963.1 Gene:Fur2 / 32604 FlyBaseID:FBgn0004598 Length:1682 Species:Drosophila melanogaster
Sequence 2:XP_005165392.1 Gene:fras1 / 563428 ZFINID:ZDB-GENE-060526-68 Length:4003 Species:Danio rerio


Alignment Length:1402 Identity:317/1402 - (22%)
Similarity:486/1402 - (34%) Gaps:406/1402 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   543 VTSGRQG----KGSIFVWASGNGGRYTDSC-NCDGYTNSIFTLSISSATQAGFKPWYLEE----- 597
            ::.|.:|    :||:|   :.|.....|:| :|..|.:.:..           ||.....     
Zfish    18 ISPGAEGACVHQGSLF---ANNTSWKPDTCQDCICYNDIVIC-----------KPTRCRNPQCDF 68

  Fly   598 -------------CSSTLATTYSSGTPGHDKSVATVDMDGSLRPDHICTVEH----TGTSASAPL 645
                         |....|.  |.|...|:..|...|...|.....:||..|    .|..|..||
Zfish    69 PRGERLRIPPNKCCPECFAP--SPGICHHEGLVYGHDSQWSNSKCSVCTCAHGKVTCGPRACPPL 131

  Fly   646 AAG-----------ICALALEANPELTWRDMQYL--VVYTSRP-APLEKENGWT--LNGVKRKYS 694
            :.|           .|.:........:|...:|.  :.:||.| ......||.|  |....:..:
Zfish   132 SCGKDQSPFIPDGNCCPVCAHNGVSCSWEGREYRDGLEWTSSPCTKCRCRNGHTECLVAECQPVT 196

  Fly   695 HKFGYGL----------------MDAGAMVSLAEQW------TSV-------------PPQHICK 724
            .|....|                |:||......|||      |.|             ||.|..|
Zfish   197 CKVNENLVVHPGQCCPQCEPNPCMEAGNEYKHGEQWQRSSCTTCVCDRGHSRCQTEKCPPLHCDK 261

  Fly   725 SR----------ENNEDRKIDGAYGSTLSTHMDV---NGCAGTINEVRYL--EHVQCRITLRFFP 774
            .:          |:....|....|...:..|.|:   .||...:.|...:  :.|:|  :....|
Zfish   262 GQTKVKRADQCCEDCATSKGSCLYEGIVRYHGDMWNGTGCEFCMCERGQVLCQRVEC--SRSECP 324

  Fly   775 RGNLRILLTSP-----MGTTSTLLFERPRDIVKSNFDDWPFLSVHFWGEKAEGRWTLQVINGG-- 832
            ||...:.|...     ..|||:..:.:|....:.....:..||            .|:::..|  
Zfish   325 RGEKLVHLPGKCCPECKTTTSSCTYSQPDQKGQKAIKSFRRLS------------NLEIVREGLC 377

  Fly   833 RRRVNQPGILSKWQ----LIFYGTSTQPMRLKSELLNSSPQLRSPSSSNPFLFPSASNIGQPANE 893
            |....|.|.::.:|    ....||.|.|.| :....:.:|:::.                     
Zfish   378 RECQCQEGHVTCYQHSCPTCPLGTLTIPHR-EQCCPDCNPEVKC--------------------- 420

  Fly   894 GGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQNVTAAIAGGSSAESLGFTASAAQLVAAPE 958
                          :::..:.:|:....|:.    ::.:|.:..|..            |.|.|:
Zfish   421 --------------HEDCLTCSGTPDHCASC----RDPSALLMNGRC------------LQACPQ 455

  Fly   959 TRDGDKKILHSCDAECDSSGCYGRGPTQCVAC--SHYRLDNTCVSRCPPRSFPNQVGICWPCHDT 1021
            ......|:..:|...|  :.|  ....:|.||  |.......||:.|....|..... |..|||.
Zfish   456 GFFAQGKVCAACQPSC--ATC--ENDFECTACGGSFLLSGRQCVATCERGLFQAHTH-CLSCHDL 515

  Fly  1022 CETCAGAGPDSCLTCAPAHLHVIDLAVCLQFCPDGYFENSRNRTCVPCEPNCASCQDHPEYCTSC 1086
            |.:|.||||..||||:.:. |::....|:..|..|::.:..|  |..|:|:||:||.....|.||
Zfish   516 CSSCQGAGPQDCLTCSDSS-HLLKDGYCVSDCGPGFYTSQGN--CYACDPSCATCQPDSPSCMSC 577

  Fly  1087 DHHLVMHEHKCYSACPLDTYETEDNKCAFCHSTCATCNGPTDQDCITCRSSRYAWQNKCLISCPD 1151
            .....:|:.||...||...|:.:..:|..|||:||:|:||....|.:|..:....|.:|:.||.:
Zfish   578 PAEHALHQGKCAPQCPAQYYKDDHGRCQACHSSCASCSGPAVSHCTSCSKALILNQGQCVESCGE 642

  Fly  1152 GFYADKKRLECMPCQEGCKTCT--SNGVCSECLQ-NWTLNKRDKCIVSGS--EGCSESEFYSQVE 1211
            |.::  :...|..|...|:.|.  .:..|::|:: ...|..::..:..||  ..| ..:.|.:.:
Zfish   643 GLFS--RAGHCHSCHSSCRVCVGPDSSDCTQCVKMEEVLQPQNGHVSHGSCMSAC-RPQHYLETD 704

  Fly  1212 GQCRPCHASCGSCNGPADTSCTSCPPNRLLEQSRCVSGCREGFFVEAGSLCSPCLHTCSQC--VS 1274
            ..||.||:||..|.|.:..:||||....:|.|.:|:|.|..|||......|..|..:|.:|  .|
Zfish   705 RTCRECHSSCSGCIGGSFQNCTSCLRPGVLHQGQCLSKCPNGFFHIQDLTCQACHPSCKECTGTS 769

  Fly  1275 RTNCSNCSKGLELQNGECRTTCADG-YYSDRGICAKCYLSCHTC-------SGPRRNQCVQCPAG 1331
            :.:||.|.....|.||.|||:|.:| |.:..|.|.:|...|..|       ||   ..|:.|...
Zfish   770 QADCSACPAHASLHNGYCRTSCPEGQYLNSVGFCDECEEGCQRCVADLQSGSG---TVCLWCKVP 831

  Fly  1332 WQLAAG-ECHPECPEGFYKSDFGCQKCHHYCKTCNDAGPLACTSC-PPHSMLDGGLC-------- 1386
            ..|..| .|.||||...|:....|:|||..|:.|:..|||:|||| .|..:...|||        
Zfish   832 RMLLLGNHCVPECPHKHYRWHGACKKCHSSCEECSADGPLSCTSCLAPEVLAPSGLCSPRCPTGY 896

  Fly  1387 ------------MECLS----------------------------SQYY-DTTSATCKTCHDSCR 1410
                        .:|||                            .||| :|::.||:.|..||.
Zfish   897 YADENRVCQKCDSQCLSCEMAGVCSSCRDPAKVLLFGECQYESCAHQYYLNTSTRTCRECDWSCN 961

  Fly  1411 SCFGPGQFSC---------------KGCVPPLHLDQLNSQCVSC------------CQNQTLAEK 1448
            :|.||.:..|               .||.|..:.|.  .:|:||            ||...|...
Zfish   962 ACRGPLRSDCLQCMEGYVLQDGICVPGCSPGFYQDA--ERCLSCEEHCEQCQAHGQCQRCQLPYA 1024

  Fly  1449 TSSAAC---CN----CDGETGECKATSTGGKRRTVVGSGSAYKSSESK------------HGSFE 1494
            :.:..|   |.    .|..|.:|.|.|.|...  .|.:|.....:|:.            ||.:.
Zfish  1025 SFNGHCVLECRKHYFLDDSTRQCTACSAGCVE--CVSAGECRVCAENTFLKDGRCIPDCGHGYYA 1087

  Fly  1495 N------DGNAREFVLRLDS----PLTAITAIAVAICLLII-----TIFSIIFAVLQRNSN---- 1540
            :      ..|:|...|.::.    |:..:..:..|  ||.|     ...|::..:||..||    
Zfish  1088 DLKTRACHANSRAPSLYINGSLLVPIGGVKPLDPA--LLSIKDADSQSESMLLQLLQPPSNGHLR 1150

  Fly  1541 -------------------HVSRNSVRY-RKIANTSSGRRKNLSAKPTSDARFIFNIGEDDDTDG 1585
                               .:.|.:||: .....|.||:....:|.|.     :|:..:......
Zfish  1151 LLENDRERSLGKDDTFTYTQLKRRAVRFIHDKEQTKSGQFTLRAADPQ-----LFSQPQTVTVQA 1210

  Fly  1586 DNSDDELDGNVGTDINNRIVYDRKGN----------------------------DHGHEFYIEST 1622
                  |.....|.|.|:|:|...|.                            .||...|:.| 
Zfish  1211 ------LSQQPPTVITNQILYINSGETAVISRSILHISDLDNPQDVFITVLDPPQHGRLTYMHS- 1268

  Fly  1623 NDIDAIEFHCNGAGAQKAETQLQRCN--ANGDDDDIL 1657
             |.....|.......:    |||..:  ::||.|.:|
Zfish  1269 -DTQVTHFKLEELDGE----QLQYVHDRSDGDQDRLL 1300

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fur2NP_727963.1 S8_pro-domain 242..318 CDD:293079
Peptidases_S8_Protein_convertases_Kexins_Fur in-like 375..674 CDD:173789 32/170 (19%)
Peptidase_S8 411..700 CDD:278510 39/199 (20%)
P_proprotein 761..849 CDD:279782 18/100 (18%)
Furin-like 966..1126 CDD:279142 53/161 (33%)
FU 970..1013 CDD:238021 11/44 (25%)
FU 1017..1067 CDD:238021 18/49 (37%)
FU 1063..1106 CDD:214589 16/42 (38%)
GF_recep_IV 1068..1232 CDD:291509 50/168 (30%)
FU 1116..1163 CDD:238021 15/46 (33%)
FU 1211..1255 CDD:214589 18/43 (42%)
FU 1259..1301 CDD:214589 16/44 (36%)
FU 1304..1348 CDD:214589 16/51 (31%)
FU 1356..1403 CDD:238021 24/96 (25%)
FU 1401..1444 CDD:214589 18/69 (26%)
fras1XP_005165392.1 VWC 26..85 CDD:278520 11/72 (15%)
VWC 93..150 CDD:278520 13/56 (23%)
VWC 157..214 CDD:278520 11/56 (20%)
VWC 219..276 CDD:278520 13/56 (23%)
VWC 283..340 CDD:278520 12/58 (21%)
VWC 364..414 CDD:302663 13/62 (21%)
FU 419..465 CDD:238021 8/96 (8%)
Furin-like_2 424..512 CDD:292535 20/108 (19%)
FU 461..503 CDD:214589 11/45 (24%)
FU 507..551 CDD:214589 18/45 (40%)
GF_recep_IV 512..669 CDD:291509 54/161 (34%)
FU 555..597 CDD:214589 16/43 (37%)
Furin-like 588..762 CDD:279142 53/176 (30%)
FU 602..645 CDD:214589 16/42 (38%)
FU 648..700 CDD:214589 10/52 (19%)
FU 704..748 CDD:214589 18/43 (42%)
Furin-like 737..911 CDD:279142 57/176 (32%)
FU 754..796 CDD:214589 16/41 (39%)
FU 855..897 CDD:214589 17/41 (41%)
Furin-like 888..1054 CDD:279142 34/167 (20%)
FU 950..994 CDD:214589 12/43 (28%)
FU 1044..1086 CDD:214589 10/43 (23%)
Cadherin_3 <1097..1196 CDD:292802 19/100 (19%)
Cadherin_3 1166..1306 CDD:292802 29/152 (19%)
Cadherin_3 1406..1538 CDD:292802
Cadherin_3 1526..1689 CDD:292802
Cadherin_3 1658..1811 CDD:292802
Cadherin_3 1777..1934 CDD:292802
Cadherin_3 1901..2056 CDD:292802
Cadherin_3 2025..2175 CDD:292802
Cadherin_3 2144..2290 CDD:292802
Cadherin_3 2258..2403 CDD:292802
Cadherin_3 2372..2534 CDD:292802
Calx-beta 2550..2647 CDD:295344
Calx-beta 2672..2771 CDD:295344
Calx-beta 2795..2891 CDD:295344
Calx-beta 2917..3008 CDD:295344
Calx-beta 3036..3130 CDD:295344
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 230 1.000 Domainoid score I2377
eggNOG 1 0.900 - - E1_COG1404
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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