DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fur2 and PCSK5

DIOPT Version :9

Sequence 1:NP_727963.1 Gene:Fur2 / 32604 FlyBaseID:FBgn0004598 Length:1682 Species:Drosophila melanogaster
Sequence 2:NP_001358972.1 Gene:PCSK5 / 5125 HGNCID:8747 Length:1887 Species:Homo sapiens


Alignment Length:2000 Identity:577/2000 - (28%)
Similarity:761/2000 - (38%) Gaps:738/2000 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   227 MFGAFSIP--EEAIYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLR 289
            :.|...:|  ...:|||.:||.|..|...|:.||:|:||||.||||:|.:||.|.|....|||:.
Human    21 LLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVI 85

  Fly   290 SSRKHQGALKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPES 354
            |||.....:..|.:|:|:|||..|.|.|||           |:..|....|              
Human    86 SSRGTHSFISMEPKVEWIQQQVVKKRTKRD-----------YDFSRAQSTY-------------- 125

  Fly   355 ISLASHSQRMEYRDVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSIL 419
                                |.||.:...||:...:.......|||:..||::|||||.:||:||
Human   126 --------------------FNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTIL 170

  Fly   420 DDGIQTNHPDLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAY 482
            ||||:..||||.||||..||.|:||||.||.|:  .:.:|||||||||||||.|.|:.|.||:|:
Human   171 DDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAAAANNSHCTVGIAF 235

  Fly   483 NASIGGVRMLDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGR 547
            ||.|||||||||.|.|:|||:::|.||.|:.||||||||:|||.|||||.||.|:||..||..||
Human   236 NAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGR 300

  Fly   548 QGKGSIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPG 612
            :|.||:||||||||||..|.|:||||||||:|:||||..::|.||||||||||||||||||| ..
Human   301 RGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSG-ES 364

  Fly   613 HDKSVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAP 677
            :||.:.|.|:      ...||..|||||||||:||||.||||||||.|||||:|:::|.|||...
Human   365 YDKKIITTDL------RQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGH 423

  Fly   678 LEKENGWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAY-GST 741
            | ..|.|..|....|.||.:|:|||||.|||..||:||:||.||:|   ..:.||:|.... .|.
Human   424 L-NANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVC---VESTDRQIKTIRPNSA 484

  Fly   742 LSTHMDVNGCAGTIN-EVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNF 805
            :.:....:||:...| .|.|||||..|||:....||:|.|.||||.||.|.||..|..|.....|
Human   485 VRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGF 549

  Fly   806 DDWPFLSVHFWGEKAEGRWTLQVIN--GGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSSP 868
            .:|.|:::|.|||:|.|.|.|:|.:  ...|....||.|.:|.|:.||||.||.           
Human   550 KNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPY----------- 603

  Fly   869 QLRSPSSSNP----FLF--------------------PSASNIG------QPANE---------- 893
               ||::..|    |.:                    |..|.:|      ...|:          
Human   604 ---SPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKN 665

  Fly   894 ----------GGNFNTD-------------------------SFASYLN--------------YQ 909
                      .|:::.|                         .:..:||              ||
Human   666 NTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQ 730

  Fly   910 NIFSSA------------------------------------------GSDPEP--------ATA 924
            :...:.                                          |.|.:|        |.|
Human   731 DTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGA 795

  Fly   925 TLDG----------------QNVTAAIAGGSSAES---------------------------LGF 946
            ..||                |:.:.:.....|:|:                           .|:
Human   796 GADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGY 860

  Fly   947 TASAAQLVAAPETRDGDKKILH----SCDAECDSSGCYGRGPTQ--CVACSHYRL--DNTCVSRC 1003
            .............:||:....|    :|:|.|  :.|  :||||  |..|...|:  |..|||.|
Human   861 LLDLGMCQMGAICKDGEYVDEHGHCQTCEASC--AKC--QGPTQEDCTTCPMTRIFDDGRCVSNC 921

  Fly  1004 P--PRSFPNQVGICWPCHDTCETCAGAGPDSCLTC-------------------APAHLHVIDLA 1047
            |  ...|.||   |.|||.||:.|.|:||..|.:|                   .|...:..:..
Human   922 PSWKFEFENQ---CHPCHHTCQRCQGSGPTHCTSCGADNYGREHFLYQGECGDSCPEGHYATEGN 983

  Fly  1048 VCLQFCPD----------------GYFENSRNRT------------------CVPCEPNCASCQ- 1077
            .||. |||                |||....|.|                  |||||..|..|. 
Human   984 TCLP-CPDNCELCHSVHVCTRCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPCEEGCLGCSL 1047

  Fly  1078 DHPEYCTSC-------DHH---------------------------------------------- 1089
            |.|..||||       |||                                              
Human  1048 DDPGTCTSCAMGYYRFDHHCYKTCPEKTYSEEVECKACDSNCGSCDQNGCYWCEEGFFLLGGSCV 1112

  Fly  1090 ----------------------------------------------------------------- 1089
                                                                             
Human  1113 RKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNEAV 1177

  Fly  1090 ----------------------------------------------------------------- 1089
                                                                             
Human  1178 STANLSVVKSLLQERRRWKVQIKRDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSC 1242

  Fly  1090 ---------------------------------------LVMHEHKCYSACPLDTYETEDNKCAF 1115
                                                   |.:||.:|||.||..:| .||..|..
Human  1243 PQGTWPSVRSGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSY-AEDGICER 1306

  Fly  1116 CHSTCATCNG------------------------------------------------------- 1125
            |.|.|.||.|                                                       
Human  1307 CSSPCRTCEGNATNCHSCEGGHVLHHGVCQENCPERHVAVKGVCKHCPEMCQDCIHEKTCKECTP 1371

  Fly  1126 -------------------------PTDQDCITC------------RSSRYAWQNKCLISCPDGF 1153
                                     |..:||:.|            .||...:...||..||.|.
Human  1372 EFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGT 1436

  Fly  1154 YADKKRLECMPCQEGCKTCTSNGVCSECLQNWTLNKRDKCIVSGSEGCSESEFYSQVEGQCRPCH 1218
            |.:|:..||..|.:.|.||:|:|.|:.|.:...:|.|..|:  .:|.||.||::.:....|:|||
Human  1437 YYEKETKECRDCHKSCLTCSSSGTCTTCQKGLIMNPRGSCM--ANEKCSPSEYWDEDAPGCKPCH 1499

  Fly  1219 ASCGSCNGPADTSCTSCPPNRLLEQSRCVSGCREGFFV-EAGSLCSPCLHTCSQCVSR--TNCSN 1280
            ..|..|.|||:..|.:||.|.||..:.||..|.||::. |..:.|:.|..:|..|..|  ..|.:
Human  1500 VKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHS 1564

  Fly  1281 CSKGLELQNGECRTTCADGYYSDR--GICAKCYLSCHTCSGPRRNQCVQCPAGWQL--AAGECHP 1341
            |..|......||...|.:|||:|.  |.|.:|..||..|.|||...|:.|...:.|  :.||||.
Human  1565 CRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHR 1629

  Fly  1342 ECPEGFY--KSDFGCQKCHHYCKTCNDAGPLACTSCPPHSMLDGGLC-MECLSSQYY--DTTSAT 1401
            .||:.:|  :|...|::||..|..|...|.|.|.||.....|.||:| .:||..:|.  :.....
Human  1630 SCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFN 1694

  Fly  1402 CKTCHDSCRSCFGPGQFSCKGCVPPLHLDQLNSQCVSCCQNQTLAEKTSSAACCNCDGETGECKA 1466
            |:.||:||..|.|||..:|..|...|.|...:|.|:.||..   ::..|:..||:|...|.||  
Human  1695 CEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNT---SDPPSAQECCDCQDTTDEC-- 1754

  Fly  1467 TSTGGKRRTVVGSGSAYKSSESKHGSFENDGNAREFVLRLDSPLTAI----TAIAVAICLLIITI 1527
                                                :||......|.    ||:.:...::::.:
Human  1755 ------------------------------------ILRTSKVRPATEHFKTALFITSSMMLVLL 1783

  Fly  1528 FSIIFAVLQRNSNHVS-RNSVRYRKIANTS-------SGRRKNLSAKPTSDARFIFNIGEDDDTD 1584
            ......|.:::...|. .....|.|:|:.:       |..|::.|.:......:     .|.|.|
Human  1784 LGAAVVVWKKSRGRVQPAAKAGYEKLADPNKSYSSYKSSYRESTSFEEDQVIEY-----RDRDYD 1843

  Fly  1585 GDNSDDELDGNVGTDINNRIVYDRKGND----HGHEFYIESTNDIDAIEF 1630
            .|:.||             |||  .|.|    ...::.:...:|||.:|:
Human  1844 EDDDDD-------------IVY--MGQDGTVYRKFKYGLLDDDDIDELEY 1878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fur2NP_727963.1 S8_pro-domain 242..318 CDD:293079 35/75 (47%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-like 375..674 CDD:173789 188/300 (63%)
Peptidase_S8 411..700 CDD:278510 185/290 (64%)
P_proprotein 761..849 CDD:279782 40/89 (45%)
Furin-like 966..1126 CDD:279142 78/525 (15%)
FU 970..1013 CDD:238021 20/48 (42%)
FU 1017..1067 CDD:238021 22/102 (22%)
FU 1063..1106 CDD:214589 26/283 (9%)
GF_recep_IV 1068..1232 CDD:291509 72/478 (15%)
FU 1116..1163 CDD:238021 20/138 (14%)
FU 1211..1255 CDD:214589 20/43 (47%)
FU 1259..1301 CDD:214589 12/43 (28%)
FU 1304..1348 CDD:214589 18/47 (38%)
FU 1356..1403 CDD:238021 16/49 (33%)
FU 1401..1444 CDD:214589 17/42 (40%)
PCSK5NP_001358972.1 S8_pro-domain 38..114 CDD:374560 35/75 (47%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 126..420 CDD:173789 188/300 (63%)
P_proprotein 505..595 CDD:366670 40/89 (45%)
Cell attachment site. /evidence=ECO:0000255 519..521 1/1 (100%)
FU 1 630..680 5/49 (10%)
GF_recep_IV 635..744 CDD:373332 10/108 (9%)
VSP 724..1100 CDD:146106 75/383 (20%)
FU 1084..1129 CDD:238021 0/44 (0%)
FU 1126..1162 CDD:214589 0/35 (0%)
FU 1209..1256 CDD:238021 0/46 (0%)
VSP 1291..>1576 CDD:146106 73/287 (25%)
GF_recep_IV 1596..1713 CDD:373332 44/116 (38%)
FU 1695..1736 CDD:214589 17/43 (40%)
AC 1. /evidence=ECO:0000250 1834..1853 9/38 (24%)
AC 2. /evidence=ECO:0000250 1865..1887 4/13 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 228 1.000 Domainoid score I2495
eggNOG 1 0.900 - - E1_COG1404
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H21244
Inparanoid 1 1.050 771 1.000 Inparanoid score I536
Isobase 1 0.950 - 0 Normalized mean entropy S3236
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D311719at33208
OrthoFinder 1 1.000 - - FOG0000204
OrthoInspector 1 1.000 - - otm41305
orthoMCL 1 0.900 - - OOG6_100362
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4005
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.720

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