DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and PCSK6

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_002561.1	Gene:	PCSK6 / 5046	HGNCID:	8569	Length:	969	Species:	Homo sapiens

Alignment Length:	1065	Identity:	416/1065 - (39%)
Similarity:	558/1065 - (52%)	Gaps:	195/1065 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 PEEAIYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGAL 298
            |...:|||.:||.:..|...||.:|..||::|.||||:|::||.|.|....|||..|||.....|
Human    65 PPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTLSSRGPHTFL 129

  Fly   299 KSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQR 363
            :.:.:|||:|||..|.|.||                            .:...|:::
Human   130 RMDPQVKWLQQQEVKRRVKR----------------------------QVRSDPQAL-------- 158

  Fly   364 MEYRDVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHP 428
                      .|.||::...|||...:..::...:|||..||::|||||.|||:||||||:.|||
Human   159 ----------YFNDPIWSNMWYLHCGDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHP 213

  Fly   429 DLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRM 491
            |||.|||..||:|:||||.||:|:  .:.:|||||||||||||.|.|::|.||:||||.|||:||
Human   214 DLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRM 278

  Fly   492 LDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVW 556
            |||.|.|||||::|.:.|::||||||||||:|||.||||||.||::||.||:..||||.||||||
Human   279 LDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVW 343

  Fly   557 ASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVD 621
            |||||||..|.|:||||||||:|:|:||||:.|:||||||||:||||||||||. .:::.:.|.|
Human   344 ASGNGGREGDYCSCDGYTNSIYTISVSSATENGYKPWYLEECASTLATTYSSGA-FYERKIVTTD 407

  Fly   622 MDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTL 686
            :      ...||..|||||.|||:.|||.|||||||.:|||||:|:|:|.|||||.| |.:.|.:
Human   408 L------RQRCTDGHTGTSVSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHL-KASDWKV 465

  Fly   687 NGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKI-------DGAYGSTLST 744
            ||...|.||.:|:||:||.|:|..|::||:||.||:|.:..:...|.|       ..|..|..:.
Human   466 NGAGHKVSHFYGFGLVDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAE 530

  Fly   745 HMDVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWP 809
            |.|        ..|.|||||..|.::....||:|:|.|.||.||.|.||.:|..|:....|.:|.
Human   531 HSD--------QRVVYLEHVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWE 587

  Fly   810 FLSVHFWGEKAEGRWTLQV--INGGRRRVNQPGILSKWQLIFYGTSTQPM------RLKSELLN- 865
            |::||.|||||||:|||::  :....|...:.|.|.:|.||.|||:..|.      :.:|.:|.
Human   588 FMTVHCWGEKAEGQWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLEL 652

  Fly   866 SSPQLRSPSSSNPFLFPSASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQN 930
            |:|:|..|.::   |.||...:                               ||      |.::
Human   653 SAPELEPPKAA---LSPSQVEV-------------------------------PE------DEED 677

  Fly   931 VTAAIAGGSSAESLGFTASAAQLVAAPETRDGDKKILHS--CDAECDSSGCYGRGPTQCVACSHY 993
            .||                        ::..|...||.:  |..||...||.|....||:.|.|:
Human   678 YTA------------------------QSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHF 718

  Fly   994 RLDNT-----CVSRCPPRSFPNQVG-ICWPCHDTCETCAGAGPDSCLTCAPAHLHVIDLAVCLQF 1052
            .|.:.     |||.||...|.:... .|..||..||||:......||:|.....|..::..|:..
Human   719 SLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTL 783

  Fly  1053 CPDGYFENSRNRTCVPCEPNCASCQDHPEYCTSCDHHLVMHEHKCYSACPLDTY-ETEDNKCAFC 1116
            ||.|::.:...:.|:.|.|:|..|.|.||.||.|.....:....|...|...|| ::|..:|..|
Human   784 CPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGEC 848

  Fly  1117 HSTCATCNGPTDQDCITCRSSRYAWQNKCLISCPDGFYADK----KRLECMPCQEGCKTCT-SNG 1176
            |.||.||.||..::||.|..:.:....||:.:|.:|||.::    ....|..|.|.|.:|. |:.
Human   849 HHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSR 913

  Fly  1177 VCSECLQNWTLNKRDKCIVSGSEGCSESEFYSQVEGQCRPCHASCGSCNGPADTSCTSCPPNRLL 1241
            .||.|...:|                      |:...|...|    :|:...:|.|.....|||.
Human   914 NCSRCKTGFT----------------------QLGTSCITNH----TCSNADETFCEMVKSNRLC 952

  Fly  1242 EQSRCVSGCREGFFVEAGSLCSPCL 1266
            |:...:..|           |..||
Human   953 ERKLFIQFC-----------CRTCL 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	33/75 (44%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	190/300 (63%)
		Peptidase_S8	411..700	CDD:278510	189/290 (65%)
		P_proprotein	761..849	CDD:279782	39/89 (44%)
		Furin-like	966..1126	CDD:279142	57/168 (34%)
		FU	970..1013	CDD:238021	17/47 (36%)
		FU	1017..1067	CDD:238021	14/49 (29%)
		FU	1063..1106	CDD:214589	13/42 (31%)
		GF_recep_IV	1068..1232	CDD:291509	48/169 (28%)
		FU	1116..1163	CDD:238021	17/50 (34%)
		FU	1211..1255	CDD:214589	10/43 (23%)
		FU	1259..1301	CDD:214589	3/8 (38%)
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
PCSK6	NP_002561.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		S8_pro-domain	73..149	CDD:293079	33/75 (44%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	160..454	CDD:173789	190/300 (63%)
		Peptidase_S8	196..479	CDD:278510	189/290 (65%)
		P_proprotein	539..629	CDD:279782	39/89 (44%)
		Cell attachment site. /evidence=ECO:0000255	553..555		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..683		9/88 (10%)
		FU 1	692..739		16/46 (35%)
		CRM (Cys-rich motif)	695..930		77/256 (30%)
		FU	695..747	CDD:238021	17/51 (33%)
		FU	743..789	CDD:214589	15/45 (33%)
		Furin-like_2	751..847	CDD:292535	29/95 (31%)
		FU	799..845	CDD:238021	15/45 (33%)
		FU	844..886	CDD:214589	16/41 (39%)
		FU 5	895..943		15/73 (21%)
		FU	896..930	CDD:214589	11/55 (20%)
		PLAC	942..965	CDD:285849	7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143393
Domainoid	1	1.000	90	1.000	Domainoid score	I7782
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52598
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		otm41305
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.660