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Protein Alignment Fur2 and FURIN

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_001276752.1	Gene:	FURIN / 5045	HGNCID:	8568	Length:	794	Species:	Homo sapiens

Alignment Length:	828	Identity:	362/828 - (43%)
Similarity:	425/828 - (51%)	Gaps:	212/828 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 EAIYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKS 300
            :.::||.:||.||.|..:|:.:|.||||:|.|||  ..:||.|.|..|:||||...|.....|:.
Human    27 QKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI--FGDYYHFWHRGVTKRSLSPHRPRHSRLQR 89

  Fly   301 ENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRME 365
            |.:|:|::||..|.|.||| .||: ||
Human    90 EPQVQWLEQQVAKRRTKRD-VYQE-PT-------------------------------------- 114

  Fly   366 YRDVSSHFIFPDPLFKEQWYLVSKNGGAKDGL---DMNVGPAWQKGYTGKGVVVSILDDGIQTNH 427
                       ||.|.:||||        .|:   |:||..||.:||||.|:|||||||||:.||
Human   115 -----------DPKFPQQWYL--------SGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNH 160

  Fly   428 PDLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVR 490
            ||||.||||.||||:|..|.||.|:  ...||:|||||||||||||.|..|||||||||.|||||
Human   161 PDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVR 225

  Fly   491 MLDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFV 555
            ||||:|.|.|||::|.|||:||.||||||||||||.|||||..||..||..||:.||.|.|||||
Human   226 MLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFV 290

  Fly   556 WASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATV 620
            ||||||||..||||||||||||:|||||||||.|..|||.|.||||||||||||.. ::|.:.|.
Human   291 WASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQ-NEKQIVTT 354

  Fly   621 DMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWT 685
            |:...      ||..||||||||||||||.||.||||..|||||||:|||.||:||.| ..|.|.
Human   355 DLRQK------CTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHL-NANDWA 412

  Fly   686 LNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNG 750
            .|||.||.||.:||||:||||||:||:.||:|.||..|......|.:.|    |..|.....|..
Human   413 TNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDI----GKRLEVRKTVTA 473

  Fly   751 CAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHF 815
            |.|..|.:..|||.|.|:||.:..||:|.|.|.|||||.||||..||.|.....|:||.|::.|.
Human   474 CLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHS 538

  Fly   816 WGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSSPQLRSPSSSNPFL 880
            |.|...|.|.|::.|  ....|..|.|:|:.|:.|||
Human   539 WDEDPSGEWVLEIEN--TSEANNYGTLTKFTLVLYGT---------------------------- 573

  Fly   881 FPSASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQNVTAAIAGGSSAESLG 945
                      |.||
Human   574 ----------APEG--------------------------------------------------- 577

  Fly   946 FTASAAQLVAAPETRDGDKKILHSCDAECDSSGCYGRGPTQ-CVACSH-YRL-DNTCVSRCPPRS 1007
                   |...||                 ||||.....:| ||.|.. :.| ..:||..|||..
Human   578 -------LPVPPE-----------------SSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGF 618

  Fly  1008 FPN---------------QVGICWPCHDTCETCAGAGPDSCLTCAPAH 1040
            .|.               :..:|.|||.:|.||.|.....||:| |:|
Human   619 APQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSC-PSH 665

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.