DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fur2 and FURIN

DIOPT Version :10

Sequence 1:NP_727963.1 Gene:Fur2 / 32604 FlyBaseID:FBgn0004598 Length:1682 Species:Drosophila melanogaster
Sequence 2:NP_002560.1 Gene:FURIN / 5045 HGNCID:8568 Length:794 Species:Homo sapiens


Alignment Length:827 Identity:362/827 - (43%)
Similarity:426/827 - (51%) Gaps:210/827 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   236 EAIYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKS 300
            :.::||.:||.||.|..:|:.:|.||||:|.|||  ..:||.|.|..|:||||...|.....|:.
Human    27 QKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI--FGDYYHFWHRGVTKRSLSPHRPRHSRLQR 89

  Fly   301 ENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRME 365
            |.:|:|::||..|.|.||| .||: ||                                      
Human    90 EPQVQWLEQQVAKRRTKRD-VYQE-PT-------------------------------------- 114

  Fly   366 YRDVSSHFIFPDPLFKEQWYL--VSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHP 428
                       ||.|.:||||  |::.       |:||..||.:||||.|:|||||||||:.|||
Human   115 -----------DPKFPQQWYLSGVTQR-------DLNVKAAWAQGYTGHGIVVSILDDGIEKNHP 161

  Fly   429 DLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRM 491
            |||.||||.||||:|..|.||.|:  ...||:|||||||||||||.|..|||||||||.||||||
Human   162 DLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRM 226

  Fly   492 LDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVW 556
            |||:|.|.|||::|.|||:||.||||||||||||.|||||..||..||..||:.||.|.||||||
Human   227 LDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVW 291

  Fly   557 ASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVD 621
            |||||||..||||||||||||:|||||||||.|..|||.|.||||||||||||.. ::|.:.|.|
Human   292 ASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQ-NEKQIVTTD 355

  Fly   622 MDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTL 686
            :...      ||..||||||||||||||.||.||||..|||||||:|||.||:||.| ..|.|..
Human   356 LRQK------CTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHL-NANDWAT 413

  Fly   687 NGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGC 751
            |||.||.||.:||||:||||||:||:.||:|.||..|......|.:.|    |..|.....|..|
Human   414 NGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDI----GKRLEVRKTVTAC 474

  Fly   752 AGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHFW 816
            .|..|.:..|||.|.|:||.:..||:|.|.|.|||||.||||..||.|.....|:||.|::.|.|
Human   475 LGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSW 539

  Fly   817 GEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSSPQLRSPSSSNPFLF 881
            .|...|.|.|::.|  ....|..|.|:|:.|:.|||                             
Human   540 DEDPSGEWVLEIEN--TSEANNYGTLTKFTLVLYGT----------------------------- 573

  Fly   882 PSASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQNVTAAIAGGSSAESLGF 946
                     |.||                                                    
Human   574 ---------APEG---------------------------------------------------- 577

  Fly   947 TASAAQLVAAPETRDGDKKILHSCDAECDSSGCYGRGPTQ-CVACSH-YRL-DNTCVSRCPPRSF 1008
                  |...||                 ||||.....:| ||.|.. :.| ..:||..|||...
Human   578 ------LPVPPE-----------------SSGCKTLTSSQACVVCEEGFSLHQKSCVQHCPPGFA 619

  Fly  1009 PN---------------QVGICWPCHDTCETCAGAGPDSCLTCAPAH 1040
            |.               :..:|.|||.:|.||.|.....||:| |:|
Human   620 PQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCLSC-PSH 665

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fur2NP_727963.1 S8_pro-domain 242..318 CDD:465126 33/75 (44%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 375..674 CDD:173789 204/302 (68%)
P_proprotein 761..849 CDD:460225 40/87 (46%)
GF_recep_IV 970..1073 CDD:464344 28/89 (31%)
VSP 1020..1379 CDD:146106 9/21 (43%)
FU 1401..1444 CDD:214589
FURINNP_002560.1 S8_pro-domain 33..107 CDD:465126 33/75 (44%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 113..402 CDD:173789 206/351 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 162..183 14/20 (70%)
P_proprotein 484..570 CDD:460225 40/87 (46%)
Cell attachment site. /evidence=ECO:0000255 498..500 1/1 (100%)
FU 1. /evidence=ECO:0000255 577..620 18/117 (15%)
FU 581..618 CDD:214589 16/53 (30%)
FU 2. /evidence=ECO:0000255 638..681 13/29 (45%)
FU 638..>675 CDD:214589 13/29 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..696
Cell surface signal. /evidence=ECO:0000303|PubMed:9412467 759..762
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 767..794
Trans Golgi network signal. /evidence=ECO:0000269|PubMed:8846780 773..779
Blue background indicates that the domain is not in the aligned region.

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