DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and Fur1

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster

Alignment Length:	1409	Identity:	462/1409 - (32%)
Similarity:	624/1409 - (44%)	Gaps:	385/1409 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 KETATAKLNRIYLCTFNRMAQSCIYFVLFLVILSPNTSCALRSSAGETQNYVGILSNDSATTTYD 138
            |.::.:|.||     ...:|::...|:|.|...:....|.:.         ||.::...||....
  Fly   100 KSSSKSKSNR-----SRPLAKTKAVFLLALQFSAVVFLCNIN---------VGFVAGSVATAASS 150

  Fly   139 V--------SSLHSSRRT--NPPSSSSSSSSNVD------------VDYRNDRELHKVDLVGLGG 181
            .        ||..||..|  .||....||:..||            :||
  Fly   151 AGGSSPAAPSSAPSSPPTVAVPPPPPPSSALKVDPNGQSPVLPPYVLDY---------------- 199

  Fly   182 ERAGQAE-TISGGKYDYNYENTHTNASAKDEIVERQSNSLDFDGVDMFGAFSIPEEAIYTNEFAV 245
            |..|:|: |.:.||:.    .:.::.|..:.||..                       ||:.:||
  Fly   200 ETGGKAKLTPNNGKFG----QSGSSGSNNNHIVGH-----------------------YTHTWAV 237

  Fly   246 NIPAGKQ-MADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSENEVKWMQQ 309
            :||.|.. |||.:|..|||:|.|:|  .|::|.|.||.||||||..:..||..|..::.|.|.:|
  Fly   238 HIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQ 300

  Fly   310 QHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYRDVSSHFI 374
            |..|.|.|||                           .:...|...|    |:.|...|..|
  Fly   301 QRAKSRSKRD---------------------------FIRMRPSRTS----SRAMSMVDAMS--- 331

  Fly   375 FPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPEAS 439
            |.|..:.:.|||  ..||   ||||||.|||:.|.|||||||:|||||::::|||:..||||:||
  Fly   332 FNDSKWPQMWYL--NRGG---GLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKAS 391

  Fly   440 FDINGNDSDPTPQ-DNGD-NKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGKVNDVVEA 502
            :|:|.:|.||.|. |..| |:|||||||||||.|.|:||.||:||.||:||||||||.|.|.|||
  Fly   392 YDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEA 456

  Fly   503 QALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGNGGRYTDS 567
            ::|||||.|||||||||||:|||.||||||.||.||||.|.|.||.||||||:||||||||..|:
  Fly   457 RSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDN 521

  Fly   568 CNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGSLRPDHIC 632
            ||||||||||:||||||||:.|..|||.|:||||||||||||..| :|.|.|.|:      .|.|
  Fly   522 CNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQG-EKQVVTTDL------HHSC 579

  Fly   633 TVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNGVKRKYSHKF 697
            ||.||||||||||||||.||.|::|..|||||:|::||.|::||.| |:..|:.|||.|:.||.|
  Fly   580 TVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANL-KDPSWSRNGVGRRVSHSF 643

  Fly   698 GYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGCAGTINEVRYLE 762
            |||||||..||.:|..|.:||.|..|:....:.|:.|......||  .:.||.|    ..|.|||
  Fly   644 GYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHITL--QLTVNHC----RSVNYLE 702

  Fly   763 HVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHFWGEKAEGRWTLQ 827
            |||.:|||....||::::.|.||..|:.|||..|..|..:|.|:.|||:|||.|||..:|.|.|:
  Fly   703 HVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLE 767

  Fly   828 VINGGRRRVNQPGILSKWQLIFYGTS-----TQPMRLKSELLNSSPQLRSPSSSNPFLFPSASNI 887
            :.|.||...:  .:|.:|.||||||:     ..|:.:...   |..:..:|:||:     :.||:
  Fly   768 IHNEGRYMGH--ALLREWSLIFYGTTQSIGPNDPISVPKP---SGSEATTPNSSS-----TTSNL 822

  Fly   888 GQ---------PANEGGNF---------------NTDSFAS---YLN-------YQNIFSSAG-- 916
            .|         |.|..|:.               |..|:.:   .||       ||.|.::.|
  Fly   823 HQAYSPQYPRIPPNNFGSSPSGGSKLPLGKVPPPNKSSYVTNNPLLNSAPPKQGYQQISATYGVI 887

  Fly   917 -----------SDPEPATATLDGQNVTAAIAGGSSAESLGFTASAAQLVAA-------------- 956
                       |..:.........|.....:||||......|..:..:..:
  Fly   888 LGKANGKSNNNSKEKTNNKGNKSNNGNKGKSGGSSGNRKEQTTQSTIIQTSTSKNKYYRISQQQQ 952

  Fly   957 ---------------PETRDGDK-------KILHSCDAECDSSGCYGRGPTQCVACSHYRLDNTC 999
                           |:...|:|       |::    .|..::.  |.|..:...........:.
  Fly   953 QKNNKQDRNGVQTQRPKANSGEKSYDEKSRKVV----GEITTNS--GNGSIKAAKQVKESTTTSS 1011

  Fly  1000 VSRCP-----------------------PRSFPNQ--------VGICWPCH-------------- 1019
            .||.|                       |:..|.|        |.:..|.:
  Fly  1012 NSRIPKLFERYEKIQAIFPELEPYENSSPKGKPKQAKQGKQFEVDLFKPTNGGNSRQGNTKKSPS 1076

  Fly  1020 -----DTCETCA-----GAGPDSCL-----------------TCAPAHLHVIDLAVCLQFCPDGY 1057
                 .|..|.:     .||..|.|                 ..|||.:.|....|  ...||
  Fly  1077 VPPPSQTMATLSILPILPAGGSSFLPDQKILKKQQLLMAAAGVMAPAQVEVEMEEV--HATPD-- 1137

  Fly  1058 FENSRNR--------------------TCVPCEP----NCASCQDHPEYCTSCDHHLVMHEHKCY 1098
            :|..:::                    |..|.:|    |.:.......|.....|:.|.::
  Fly  1138 YEARKDQRKEVNGPNAQITQWDMIFYGTETPAQPDDVANPSQSNQFNLYGNDMAHNDVEYD---- 1198

  Fly  1099 SACPLDTYE------------TEDNKCAFCHSTCATCNGPTDQDCITCRSSRYAWQNKCLISCP- 1150
                 .|.:            |.|      ||..|.|...:|:.|:.|..|.|.::::|...||
  Fly  1199 -----STGQWRNMQQVGEVGMTRD------HSNTAACLKWSDRKCLECNDSAYMFEDQCYDVCPV 1252

  Fly  1151 -----DGFYADKKRLECMPCQEGCKTCTSNGVCSECLQNWTL-NKRDKCIVSGSEGCSESEFYSQ 1209
                 |.|.|::...:....:......:|:.:....|.:.:| :|:|.  :...:....|.....
  Fly  1253 HTYPLDKFQAEEDEQDDEVTRGPVNPYSSSPMDHSLLMSNSLDDKQDP--LQAEDRRRRSSLTQL 1315

  Fly  1210 VE---GQCRPCHASCGSCNGPADTSCTSCPP----NRLLEQSRC 1246
            ||   ..|..|..||..|.|...:.|::|.|    .::|.::.|
  Fly  1316 VEVPSRVCAACDRSCLECYGALASQCSTCSPGSQLRKILNETFC 1359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	35/76 (46%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	202/300 (67%)
		Peptidase_S8	411..700	CDD:278510	197/290 (68%)
		P_proprotein	761..849	CDD:279782	39/87 (45%)
		Furin-like	966..1126	CDD:279142	39/267 (15%)
		FU	970..1013	CDD:238021	9/73 (12%)
		FU	1017..1067	CDD:238021	16/110 (15%)
		FU	1063..1106	CDD:214589	7/66 (11%)
		GF_recep_IV	1068..1232	CDD:291509	38/189 (20%)
		FU	1116..1163	CDD:238021	15/52 (29%)
		FU	1211..1255	CDD:214589	12/43 (28%)
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	35/76 (46%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	202/300 (67%)
		Peptidase_S8	363..646	CDD:278510	197/290 (68%)
		P_proprotein	701..787	CDD:279782	39/87 (45%)
		FU	1320..>1350	CDD:214589	9/29 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I7603
eggNOG	1	0.900	-	-		E1_COG1404
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12785at7147
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		otm46475
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	1	1.100	-	-	P	PTHR42884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.820