DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur2 and RSPO4

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	XP_016883328.1	Gene:	RSPO4 / 343637	HGNCID:	16175	Length:	266	Species:	Homo sapiens

Alignment Length:	185	Identity:	52/185 - (28%)
Similarity:	69/185 - (37%)	Gaps:	36/185 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1072 NCASC--QDHPEYCTSCDHHL--------VMHEHKCYSACPLDTY---ETEDNKCAFCHSTCATC 1123
            ||..|  ......|::|...|        :....||...||...:   ..|.|:|..|.:||.:|
Human    34 NCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESC 98

  Fly  1124 NGPTDQD-CITCRSSRYAWQNKCLISCPDGFYADKKRLECM-PCQ----EGCKTCTSNGVCSECL 1182
               ..|| ||.|:...|.::.|||.:||.|..|.:...||. .|:    .|...||.||  ..|.
Human    99 ---FSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCTHNG--KTCG 158

  Fly  1183 QNWTLNKRDKCIVSGSEGCSESEFYSQVEGQCRPCHASCGSCNGPADTSCTSCPP 1237
            ..|.|..|.:  .:|..|..|:. ..||..:.|.|         |....|....|
Human   159 SAWGLESRVR--EAGRAGHEEAA-TCQVLSESRKC---------PIQRPCPGGEP 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789
		Peptidase_S8	411..700	CDD:278510
		P_proprotein	761..849	CDD:279782
		Furin-like	966..1126	CDD:279142	17/66 (26%)
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589	10/43 (23%)
		GF_recep_IV	1068..1232	CDD:291509	50/178 (28%)
		FU	1116..1163	CDD:238021	18/47 (38%)
		FU	1211..1255	CDD:214589	5/27 (19%)
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
RSPO4	XP_016883328.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810