DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur2 and Pcsk9

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_954862.2	Gene:	Pcsk9 / 298296	RGDID:	728909	Length:	691	Species:	Rattus norvegicus

Alignment Length:	435	Identity:	98/435 - (22%)
Similarity:	155/435 - (35%)	Gaps:	113/435 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 HVSKRSLRSSRKHQGALKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSP---YNLLRQHGGYVVD 343
            ||:..:.|...|....|.....|..|:   |..|.:.:.....|.|::.   |.:...|..|.:.
  Rat    57 HVATATFRRCSKEAWRLPGTYVVVLME---ETQRLQVEQTAHRLQTWAARRGYVIKVLHVFYDLF 118

  Fly   344 PNPHLSFSPESISLASHSQRMEYRDVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKG 408
            |...:..|.:.:.||.....:||.:..| .:|...:   .|.|            ..:.||||:.
  Rat   119 PGFLVKMSSDLLGLALKLPHVEYIEEDS-LVFAQSI---PWNL------------ERIIPAWQQT 167

  Fly   409 YTGKG------VVVSILDDGIQTNHPDLAQNYDPEASFDINGNDSDPTPQDNGD---------NK 458
            .....      |.|.:||..||:.|.::      |....|  .|.:..|:::|.         :.
  Rat   168 EEDSSPDGSSQVEVYLLDTSIQSGHREI------EGRVTI--TDFNSVPEEDGTRFHRQASKCDS 224

  Fly   459 HGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGKVNDVVEAQALSL---------NPSHIDI 514
            |||..||.|:.      ...|||...|:..:|:|:.:....|....:.|         .||
  Rat   225 HGTHLAGVVSG------RDAGVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIRKSQLIQPS---- 279

  Fly   515 YSASWGPEDDGSTVDGP--------GPLARRAFIYGVTSGRQGK-GSIFVWASGNGGRYTDSC-N 569
                           ||        |..:|   |......|..: |.:.|.|:||  ...|:| .
  Rat   280 ---------------GPLVVLLPLAGGYSR---ILNTACQRLARTGVVLVAAAGN--FRDDACLY 324

  Fly   570 CDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSS----GTPGHDKSVATVDMDGSLRPDH 630
            .......:.|:   .||.|..:|..|    .||.|.:..    ..||.|...|:.|..
  Rat   325 SPASAPEVITV---GATNAQDQPVTL----GTLGTNFGRCVDLFAPGKDIIGASSDCS------- 375

  Fly   631 ICTVEHTGTSASAPLAAGICALALEANPELTWRDM-QYLVVYTSR 674
            .|.:..:|||.:|...|||.|:.|..:|.||..:: |.|::::::
  Rat   376 TCYMSQSGTSQAAAHVAGIVAMMLNRDPALTLAELRQRLILFSTK 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	9/35 (26%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	77/337 (23%)
		Peptidase_S8	411..700	CDD:278510	70/303 (23%)
		P_proprotein	761..849	CDD:279782
		Furin-like	966..1126	CDD:279142
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
Pcsk9	NP_954862.2	Inhibitor_I9	76..148	CDD:283552	16/75 (21%)
		Peptidases_S8_PCSK9_ProteinaseK_like	155..420	CDD:173790	76/328 (23%)
		Peptidase_S8	179..415	CDD:278510	69/287 (24%)
		C-terminal domain. /evidence=ECO:0000250	449..691
		Cell attachment site. /evidence=ECO:0000255	495..497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337146
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740