DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur2 and RSPO1

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_001033722.1	Gene:	RSPO1 / 284654	HGNCID:	21679	Length:	263	Species:	Homo sapiens

Alignment Length:	190	Identity:	52/190 - (27%)
Similarity:	79/190 - (41%)	Gaps:	55/190 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1018 CHDTCETCAGAGPDSCLTCAPAHLHVID------LAVCLQFCPDGYFENSRN---RTCVPCE-PN 1072
            |...||.|:..  :.||.|:|....:::      :.|||..||.|||: :||   ..|:.|: .:
Human    40 CAKGCELCSEV--NGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFD-ARNPDMNKCIKCKIEH 101

  Fly  1073 CASCQDHPEYCTSCDHHLVMHEHKCYSACPLDTYETEDNKCAFCHSTCATCNGPTDQDCITCRSS 1137
            |.:|..| .:||.|...|.:|:.:||.|||      |.:..|   :....|:.|..     |..|
Human   102 CEACFSH-NFCTKCKEGLYLHKGRCYPACP------EGSSAA---NGTMECSSPAQ-----CEMS 151

  Fly  1138 RYA-W------QNKC------------LISCPDGFYA----DKKRLEC----MPCQEGCK 1170
            .:: |      |..|            ::..|.|.:|    .|:...|    :||.||.|
Human   152 EWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRVPCPEGQK 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789
		Peptidase_S8	411..700	CDD:278510
		P_proprotein	761..849	CDD:279782
		Furin-like	966..1126	CDD:279142	36/117 (31%)
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021	18/57 (32%)
		FU	1063..1106	CDD:214589	16/46 (35%)
		GF_recep_IV	1068..1232	CDD:291509	33/131 (25%)
		FU	1116..1163	CDD:238021	12/73 (16%)
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
RSPO1	NP_001033722.1	FU 1	34..85		15/46 (33%)
		Furin-like_2	42..144	CDD:318185	35/114 (31%)
		FU 2	91..135		16/50 (32%)
		PTZ00441	<141..>227	CDD:240420	17/76 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..263		4/6 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810