Protein Alignment Fur2 and PCSK9

DIOPT Version :9

• Sequence 1: NP_727963.1
• Gene: Fur2 / 32604
• FlyBaseID: FBgn0004598
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: NP_777596.2
• Gene: PCSK9 / 255738
• HGNCID: 20001
• Length: 692
• Species: Homo sapiens
• Alignment Length: 434
• Identity: 96/434 - (22%)
• Similarity: 151/434 - (34%)
• Gaps: 120/434 - (27%)

  Fly   281 HHVSKRSLRSSRKHQGALKSENEVKWMQQQHEKVRRK------RDGPYQDLPTYSPYNLLRQHG- 338
            |..:|...|....:...||.|..:    .|.|:..|:      |.|       |....|...||
Human    65 HRCAKDPWRLPGTYVVVLKEETHL----SQSERTARRLQAQAARRG-------YLTKILHVFHGL 118

  Fly   339 --GYVVDPN----------PHLSFSPESISLASHSQRMEYRDVSSHFIFPDPLFKEQWYLVSKNG 391
              |::|..:          ||:.:..|..|:.:.|.......::      .|.::...|
Human   119 LPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERIT------PPRYRADEY------ 171

  Fly   392 GAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPEASFDINGNDSDPTPQDNGD 456
            ...||              |..|.|.:||..||::|.::...        :...|.:..|:::|.
Human   172 QPPDG--------------GSLVEVYLLDTSIQSDHREIEGR--------VMVTDFENVPEEDGT 214

  Fly   457 ---------NKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGKVNDVVEAQALSLNPSHI 512
                     :.|||..||.|:.      ...|||..||:..:|:|:.:....|....:.|
Human   215 RFHRQASKCDSHGTHLAGVVSG------RDAGVAKGASMRSLRVLNCQGKGTVSGTLIGL----- 268

  Fly   513 DIYSASWGPEDDGSTVDGPGPL-------ARRAFIYGVTSGRQGK-GSIFVWASGNGGRYTDSC- 568
            :....|       ..|...|||       ...:.:......|..: |.:.|.|:||  ...|:|
Human   269 EFIRKS-------QLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGN--FRDDACL 324

  Fly   569 NCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSS----GTPGHDKSVATVDMDGSLRPD 629
            ........:.|:   .||.|..:|..|    .||.|.:..    ..||.|...|:.|..
Human   325 YSPASAPEVITV---GATNAQDQPVTL----GTLGTNFGRCVDLFAPGEDIIGASSDCS------ 376

  Fly   630 HICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTS 673
             .|.|..:|||.:|...|||.|:.|.|.||||..:::..:::.|
Human   377 -TCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLIHFS 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	9/42 (21%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	74/321 (23%)
		Peptidase_S8	411..700	CDD:278510	70/285 (25%)
		P_proprotein	761..849	CDD:279782
		Furin-like	966..1126	CDD:279142
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
PCSK9	NP_777596.2	Inhibitor_I9	77..149	CDD:283552	17/82 (21%)
		Peptidases_S8_PCSK9_ProteinaseK_like	156..421	CDD:173790	74/332 (22%)
		Peptidase_S8	180..422	CDD:278510	69/282 (24%)
		C-terminal domain	450..692

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143394
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740