DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and Pcsk6

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	XP_038957724.1	Gene:	Pcsk6 / 25507	RGDID:	3246	Length:	950	Species:	Rattus norvegicus

Alignment Length:	1050	Identity:	421/1050 - (40%)
Similarity:	549/1050 - (52%)	Gaps:	167/1050 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 PEEAIYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGAL 298
            |...:|||.:||.:..|...||.:|..||::|.||||:||:||.|.|....|||..|||.....|
  Rat    48 PPRPVYTNHWAVQVLGGPGAADRVAAAHGYLNLGQIGNLDDYYHFYHSKTFKRSTLSSRGPHTFL 112

  Fly   299 KSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQR 363
            :.:.:|||:|||..|.|.||...
  Rat   113 RMDPQVKWLQQQEVKRRVKRQAR------------------------------------------ 135

  Fly   364 MEYRDVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHP 428
                  |....|.||::...||:...:..::...:|||..||::|||||.|||:||||||:.|||
  Rat   136 ------SDSLYFNDPIWSNMWYMHCADKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHP 194

  Fly   429 DLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRM 491
            |||.|||..||:|:||||.||:|:  .:.:|||||||||||||.|.|::|.||:||||.|||:||
  Rat   195 DLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRM 259

  Fly   492 LDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVW 556
            |||.|.|||||::|.:.|::||||||||||:|||.||||||.||::||.||:..||||.||||||
  Rat   260 LDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVW 324

  Fly   557 ASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVD 621
            |||||||..|.|:||||||||:|:|:||.|:.|.||||||||:||||||||||. .:::.:.|.|
  Rat   325 ASGNGGREGDHCSCDGYTNSIYTISVSSTTENGHKPWYLEECASTLATTYSSGA-FYERKIVTTD 388

  Fly   622 MDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTL 686
            :      ...||..|||||.|||:.|||.|||||||.:|||||:|:|:|.|||||.| |.:.|.:
  Rat   389 L------RQRCTDGHTGTSVSAPMVAGIIALALEANNQLTWRDVQHLLVKTSRPAHL-KASDWKV 446

  Fly   687 NGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGC 751
            ||...|.||.:|:||:||.|:|..|.:||:||.||:|.:..:...|.|...  ..|.|....|.|
  Rat   447 NGAGHKVSHLYGFGLVDAEALVLEARKWTAVPSQHMCVATADKRPRSIPVV--QVLRTTALTNAC 509

  Fly   752 AGTINE-VRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHF 815
            |...:: |.|||||..||::....||:|:|.|.||.||.|.||.:|..|.....|.:|.|::||.
  Rat   510 ADHSDQRVVYLEHVVVRISISHPRRGDLQIHLISPSGTKSQLLAKRLLDFSNEGFTNWEFMTVHC 574

  Fly   816 WGEKAEGRWTLQV--INGGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSSPQLRSPSSSNP 878
            |||||||.|||:|  |....|...:.|.|.:|.||.|||:..|.|
  Rat   575 WGEKAEGEWTLEVQDIPSQVRNPEKQGKLKEWSLILYGTAEHPYR-------------------- 619

  Fly   879 FLFPSASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQNVTAAIAGGSSAES 943
                                  :|:|:.:...:...:..:.||..|  :|....|.    :..|.
  Rat   620 ----------------------TFSSHQSRSRMLELSVPEQEPLKA--EGPPPQAE----TPEEE 656

  Fly   944 LGFTASAAQLVAAPETRDGDKKILHSCDAECDSSGCYGRGPTQCVACSHYRLDNT-----CVSRC 1003
            ..:||.:.|  .:|.|..     ...|..||...||.|....||:.|.|:.|.|:     |||.|
  Rat   657 EEYTAPSIQ--GSPNTLQ-----TSVCHPECGDKGCDGPSADQCLNCVHFSLGNSKTNRKCVSEC 714

  Fly  1004 PPRSFPNQVG-ICWPCHDTCETCAGAGPDSCLTCAPAHLHVIDLAVCLQFCPDGYFENSRNRTCV 1067
            |...|.:... .|..||..||||.|..|..||:|.....|..:...|:..||.|.:.:...|.|:
  Rat   715 PLGYFGDTAARRCRRCHKGCETCTGRSPTQCLSCRRGFYHHQETNTCVTLCPAGLYADESQRLCL 779

  Fly  1068 PCEPNCASCQDHPEYCTSCDHHLVMHEHKCYSACPLDTY-ETEDNKCAFCHSTCATCNGPTDQDC 1131
            .|.|:|..|.|.||.||.|.....:....|...|...|| ::|..:|..||.||.||.||:.::|
  Rat   780 RCHPSCQKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCRTCVGPSREEC 844

  Fly  1132 ITCRSSRYAWQNKCLISCPDGFYADK----KRLECMPCQEGCKTCT-SNGVCSECLQNWTLNKRD 1191
            |.|..|.:....||:.:|.:|||.::    ....|..|.|.|.:|. |:..||.|...:|
  Rat   845 IHCAKSFHFQDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCEGSSRNCSRCKAGFT----- 904

  Fly  1192 KCIVSGSEGCSESEFYSQVEGQCRPCHASCGSCNGPADTSCTSCPPNRLLEQSRCVSGCREGFFV 1256
                             |:...|...|    :|:...:|.|.....|||.|:...:..|
  Rat   905 -----------------QLGTSCITNH----TCSNADETFCEMVKSNRLCERKLFIQFC------ 942

  Fly  1257 EAGSLCSPCL 1266
                 |..||
  Rat   943 -----CRTCL 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	34/75 (45%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	188/300 (63%)
		Peptidase_S8	411..700	CDD:278510	188/290 (65%)
		P_proprotein	761..849	CDD:279782	42/89 (47%)
		Furin-like	966..1126	CDD:279142	59/166 (36%)
		FU	970..1013	CDD:238021	18/47 (38%)
		FU	1017..1067	CDD:238021	17/49 (35%)
		FU	1063..1106	CDD:214589	14/42 (33%)
		GF_recep_IV	1068..1232	CDD:291509	49/169 (29%)
		FU	1116..1163	CDD:238021	18/50 (36%)
		FU	1211..1255	CDD:214589	10/43 (23%)
		FU	1259..1301	CDD:214589	2/7 (29%)
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
Pcsk6	XP_038957724.1	S8_pro-domain	56..132	CDD:406785	34/75 (45%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	141..435	CDD:173789	188/300 (63%)
		P_proprotein	520..610	CDD:396185	42/89 (47%)
		GF_recep_IV	675..785	CDD:405525	39/109 (36%)
		FU	781..826	CDD:238021	15/44 (34%)
		FU	825..867	CDD:214589	17/41 (41%)
		FU	877..911	CDD:214589	11/55 (20%)
		PLAC	923..946	CDD:400844	7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337145
Domainoid	1	1.000	93	1.000	Domainoid score	I7355
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52598
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		otm45432
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.660