DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and krp1

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_594835.1	Gene:	krp1 / 2542576	PomBaseID:	SPAC22E12.09c	Length:	709	Species:	Schizosaccharomyces pombe

Alignment Length:	647	Identity:	233/647 - (36%)
Similarity:	327/647 - (50%)	Gaps:	113/647 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 SLDNYYLFQHHHVSKRSLRSSRKHQGALKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLR 335
            :|..::|.:.|..|..|::||.:.:|.   :..:..:::|..:.|.|||
pombe    58 NLKYHHLIKLHKGSDDSVQSSIRKRGI---DAGILELERQTPRWRYKRD---------------- 103

  Fly   336 QHGGYVVDPNPHLSFSPESISLASHSQRMEYRDVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMN 400
                                  ||.|..: ..:.|:||...||||..||::.:.|   ..|.|:|
pombe   104 ----------------------ASESDEL-LNEFSNHFGISDPLFYGQWHIFNSN---NPGHDLN 142

  Fly   401 VGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPEASFDINGNDSDPTPQDNGDNKHGTRCAG 465
            :...|..||.|:.|.|:.:||||...||||...|....|:|.|.|.:||.|: ..|::|||||||
pombe   143 LREVWDAGYFGENVTVAFVDDGIDFKHPDLQAAYTSLGSWDFNDNIADPLPK-LSDDQHGTRCAG 206

  Fly   466 EVAAVAFNNFCGVGVAYNASIGGVRMLDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDG 530
            |||| |:|:.||||:|..|.:.|:|:|...:.|.||::||:.......|||.||||.|||..:|.
pombe   207 EVAA-AWNDVCGVGIAPRAKVAGLRILSAPITDAVESEALNYGFQTNHIYSCSWGPADDGRAMDA 270

  Fly   531 PGPLARRAFIYGVTSGRQGKGSIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYL 595
            |....|||.:.||.:||.|.|||||:||||||.|.|:||.||||||||:.:|.:.......|:|.
pombe   271 PNTATRRALMNGVLNGRNGLGSIFVFASGNGGHYHDNCNFDGYTNSIFSATIGAVDAEHKIPFYS 335

  Fly   596 EECSSTLATTYSSGTPGHDKSVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPEL 660
            |.|::.|.:.||||:   ..|:.|.:.:|:      ||..|.||||:||||:.:.||||...|:|
pombe   336 EVCAAQLVSAYSSGS---HLSILTTNPEGT------CTRSHGGTSAAAPLASAVYALALSIRPDL 391

  Fly   661 TWRDMQYLVVYTSRPAPLEKENG-WTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICK 724
            :|||:|::.||::.|.....:|. |.......::||.||:|.:||...|.:|:.|..|.||....
pombe   392 SWRDIQHITVYSASPFDSPSQNAEWQKTPAGFQFSHHFGFGKLDASKFVEVAKDWQVVNPQTWLI 456

  Fly   725 SRENNEDRKIDGAYGSTLSTHMDVNGCAGTINEV----------------RYLEHVQCRITLRFF 773
            :.|.|    ::.::||       ||.  .||.|:                :.||||..|:.:.|.
pombe   457 APEIN----VNKSFGS-------VNN--ETITEMVSEFTVTKDMIEKSNFKRLEHVTVRVCIPFN 508

  Fly   774 PRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHFWGEKAEGRWTLQV--INGGRRRV 836
            .||.|.|||.||.|..|.|..|||.|.....|.||.|::|..|.|..||.|.|.|  .:||:..
pombe   509 RRGALEILLESPSGIRSILASERPYDENSKGFLDWTFMTVQHWAEPPEGVWKLLVNDRSGGKHE- 572

  Fly   837 NQPGILSKWQLIFYGTSTQP----------MRLKSEL-----------LNSSPQLRSPSSSN 877
               |....|||..:|.|..|          :.|..|:           |.:|..|.||:|::
pombe   573 ---GTFENWQLALWGESENPSNTAPLPYDTLELPKEMVLGIYSEPNSDLTNSSTLLSPTSTS 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	10/46 (22%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	139/298 (47%)
		Peptidase_S8	411..700	CDD:278510	133/289 (46%)
		P_proprotein	761..849	CDD:279782	39/89 (44%)
		Furin-like	966..1126	CDD:279142
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
krp1	NP_594835.1	Peptidases_S8_Protein_convertases_Kexins_Fur in-like	120..404	CDD:173789	139/297 (47%)
		Peptidase_S8	153..415	CDD:278510	128/272 (47%)
		Peptidases_S8_S53	<369..441	CDD:299169	30/71 (42%)
		COG4935	450..645	CDD:227271	61/199 (31%)
		P_proprotein	496..582	CDD:279782	39/89 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	250	1.000	Domainoid score	I407
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		otm46973
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	1	1.100	-	-	O	PTHR42884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.810