DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and Pcsk2

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_036878.1	Gene:	Pcsk2 / 25121	RGDID:	3273	Length:	637	Species:	Rattus norvegicus

Alignment Length:	639	Identity:	288/639 - (45%)
Similarity:	375/639 - (58%)	Gaps:	75/639 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 FSIPEEAIYTNEFAVNI-PAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKH 294
            |:..|..::||.|.|.: ..|::.|..:|.:|||..| ::...:..|.|.|:.::|...|.|..|
  Rat    21 FASAERPVFTNHFLVELHKDGEEEARQVAAEHGFGVR-KLPFAEGLYHFYHNGLAKAKRRRSLHH 84

  Fly   295 QGALKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLAS 359
            :..|:.:..:|...||....|:||.
  Rat    85 KRQLERDPRIKMALQQEGFDRKKRG---------------------------------------- 109

  Fly   360 HSQRMEYRDVSSHFI-FPDPLFKEQWYLVSKNGGAKD---GLDMNVGPAWQKGYTGKGVVVSILD 420
                  |||::...| ..||||.:||||.  |.|..|   |||:||..||:.|||||||.:.|:|
  Rat   110 ------YRDINEIDINMNDPLFTKQWYLF--NTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMD 166

  Fly   421 DGIQTNHPDLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYN 483
            |||...|||||.||:.:||:|.:.||..|.|:  |:..|.|||||||||:|.|.||.||||||||
  Rat   167 DGIDYLHPDLAYNYNSDASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAASNNICGVGVAYN 231

  Fly   484 ASIGGVRMLDGK-VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGR 547
            :.:.|:||||.. :.|::||.::|..|..||||||||||.|:|.|||||..|..:|...||..||
  Rat   232 SKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGR 296

  Fly   548 QGKGSIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPG 612
            .|||||:|||||:||.| |.||||||.:|::|:||:||...|....|.|.||||||:|:|:|...
  Rat   297 GGKGSIYVWASGDGGSY-DDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKR 360

  Fly   613 H-DKSVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPA 676
            : :..|||.|:.|:      ||:.|:||||:||.|||:.|||||||.:|||||||:|.|.||:..
  Rat   361 NPEAGVATTDLYGN------CTLRHSGTSAAAPEAAGVFALALEANVDLTWRDMQHLTVLTSKRN 419

  Fly   677 PLEKE-NGWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHIC--KSRENNEDRKIDGAY 738
            .|..| :.|..|||..:::|.||||::||||||.:|:.|.:||.:..|  .|.:|.|.....|..
  Rat   420 QLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQNPEKIPPTGKL 484

  Fly   739 GSTLSTHMDVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPR-DIVK 802
            ..||.|    |.|.|..|.||||||||..||:....||:|.|.:||||||.|.||..||| |..|
  Rat   485 VLTLQT----NACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSK 545

  Fly   803 SNFDDWPFLSVHFWGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQP 856
            ..||.|||::.|.|||.|.|.|||::  |......|.|:|.:|.|:.:||.:.|
  Rat   546 VGFDKWPFMTTHTWGEDARGTWTLEL--GFVGSAPQKGLLKEWTLMLHGTQSAP 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	21/76 (28%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	172/305 (56%)
		Peptidase_S8	411..700	CDD:278510	161/293 (55%)
		P_proprotein	761..849	CDD:279782	45/88 (51%)
		Furin-like	966..1126	CDD:279142
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
Pcsk2	NP_036878.1	S8_pro-domain	32..108	CDD:293079	21/76 (28%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	121..417	CDD:173789	172/304 (57%)
		Peptidase_S8	157..434	CDD:278510	157/283 (55%)
		P_proprotein	503..590	CDD:279782	45/88 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820