DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur2 and Pcsk7

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_001268863.1	Gene:	Pcsk7 / 18554	MGIID:	107421	Length:	770	Species:	Mus musculus

Alignment Length:	835	Identity:	274/835 - (32%)
Similarity:	406/835 - (48%)	Gaps:	164/835 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 GVDMFGAFSIPEEAIYTNEFAVNIPA--GK-------QMADVIATKHGFINRGQIGSLDNYYLFQ 279
            |:|:.|...:        .:||::.:  |:       |.||.:|...|.:|.|:||.|..:|||.
Mouse    42 GLDILGTGGL--------SWAVHLDSLEGERKEESLTQQADAVAQAAGLVNAGRIGELQGHYLFV 98

  Fly   280 HHHVSKRSLRSSRKHQGALKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDP 344
                      ....|:.|:    ||:.|:||.|.|..:.:
Mouse    99 ----------QPTGHRQAM----EVEAMRQQAEAVLARHE------------------------- 124

  Fly   345 NPHLSFSPESISLASHSQRMEYRDVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGY 409
                       ::..||::...:.......|.||.:.:||:|   |.....|.|:||...|::..
Mouse   125 -----------AVRWHSEQTLLKRAKRSIHFNDPKYPQQWHL---NNRRSPGRDINVTGVWERNV 175

  Fly   410 TGKGVVVSILDDGIQTNHPDLAQNYDPEASFDINGNDSDPTP---QDNGDNKHGTRCAGEVAAVA 471
            ||:||.|.::|||::....|:|.||.||.|:|:|.||.||.|   ::|| |.||||||||:|||.
Mouse   176 TGRGVTVVVVDDGVEHTVQDIAPNYSPEGSYDLNSNDPDPMPHPDEENG-NHHGTRCAGEIAAVP 239

  Fly   472 FNNFCGVGVAYNASIGGVRMLDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLAR 536
            .|:||.|||||.:.|.|:|:|||.:.|.:||.|.:.:....||||.||||:|||.|||||..|.:
Mouse   240 NNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDDDGKTVDGPHQLGK 304

  Fly   537 RAFIYGVTSGRQGKGSIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSST 601
            .|..:||.:||||.|||||.||||||::.|:||.|||.|||:|::|.:..:.|..|:|.|||:|.
Mouse   305 AALQHGVMAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEEGRMPFYAEECASM 369

  Fly   602 LATTYSSGTPGHDK---SVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWR 663
            ||.|:|.|    ||   |:.|.|.|  |:....||..||||||:||||||:.||.|:..|.||||
Mouse   370 LAVTFSGG----DKMLRSIVTTDWD--LQKGTGCTEGHTGTSAAAPLAAGMIALMLQVRPCLTWR 428

  Fly   664 DMQYLVVYTSRPAPLEKEN---GWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKS 725
            |:|:::|:|:    ::.|:   .|..|.....:||:.|:||::|..:|:.|:.|||||......|
Mouse   429 DVQHIIVFTA----IQYEDHHADWLTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVPYLASYVS 489

  Fly   726 RENNEDRKIDGAYGS------TLSTHMDVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTS 784
            ....|::.:..:..|      ...|.::::|       ::.||||...:::....||:|.:.|..
Mouse   490 PMLKENKAVPRSPHSLEVLWNVSRTDLEMSG-------LKTLEHVAVTVSITHPRRGSLELKLFC 547

  Fly   785 PMGTTSTLLFERPRDIVKSNFDDWPFLSVHFWGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIF 849
            |.|..|.:...|..|...:.|:.|.|.:|..|||:|.|.:.|.:.:.|...: |.|||.:|||..
Mouse   548 PSGMMSLIGAPRSMDSDPNGFNAWTFSTVRCWGERARGVYRLVIRDVGDEPL-QMGILQQWQLTL 611

  Fly   850 YGTSTQPMRLK--SELLNSSPQLRSPSSSNPFLFPSASNIGQPANEGGNFNTDSFASY------- 905
            ||:...|:.:|  ..||.|:  :......:.|..|....:..|..:|.....::..:.
Mouse   612 YGSMWSPVDIKDRQSLLESA--MSGKYLHDGFTLPCPPGLKIPEEDGYTITPNTLKTLVLVGCFS 674

  Fly   906 ------------LNYQNIFSSAGSDPEPATATLDGQNVTAAIAGGSSAESLGFTASAAQLVAAPE 958
                        |:.:|..|:.|............||...|   |::.||:...:|
Mouse   675 VFWTIYYMLEVCLSQRNKASTHGCRKGCCPWAPRRQNSKDA---GTALESMPLCSS--------- 727

  Fly   959 TRDGDKKILHSCDAECDSSGCYGRGPTQCVACSHY---RLDNTCVSRCPPRSFPN 1010
                  |.|...|:|      :|    .|...|.:   .||      |||...|:
Mouse   728 ------KDLDGVDSE------HG----DCTTASSFLAPELD------CPPHQPPD 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	25/84 (30%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	157/304 (52%)
		Peptidase_S8	411..700	CDD:278510	150/297 (51%)
		P_proprotein	761..849	CDD:279782	31/87 (36%)
		Furin-like	966..1126	CDD:279142	12/48 (25%)
		FU	970..1013	CDD:238021	11/44 (25%)
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
Pcsk7	NP_001268863.1	S8_pro-domain	52..140	CDD:406785	27/137 (20%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	144..438	CDD:173789	156/303 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..228		17/33 (52%)
		P_proprotein	524..611	CDD:396185	31/87 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720