DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and Pcsk6

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_035178.1	Gene:	Pcsk6 / 18553	MGIID:	102897	Length:	959	Species:	Mus musculus

Alignment Length:	1056	Identity:	425/1056 - (40%)
Similarity:	547/1056 - (51%)	Gaps:	179/1056 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 PEEAIYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGAL 298
            |...:|||.:||.:..|...||.:|..||::|.||||:||:||.|.|....|||..|||.....|
Mouse    57 PPRPVYTNHWAVQVLGGPGAADRVAAAHGYLNLGQIGNLDDYYHFYHSKTFKRSTLSSRGPHTFL 121

  Fly   299 KSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQR 363
            :.:.:|||:|||..|.|.||...
Mouse   122 RMDPQVKWLQQQEVKRRVKRQAR------------------------------------------ 144

  Fly   364 MEYRDVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHP 428
                  |....|.||::...||:...:..::...:|||..||::|||||.|||:||||||:.|||
Mouse   145 ------SDSLYFNDPIWSNMWYMHCTDKNSRCRSEMNVQAAWKRGYTGKNVVVTILDDGIERNHP 203

  Fly   429 DLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRM 491
            |||.|||..||:|:||||.||:|:  .:.:|||||||||||||.|.|::|.||:||||.|||:||
Mouse   204 DLAPNYDSYASYDVNGNDYDPSPRYDASNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRM 268

  Fly   492 LDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVW 556
            |||.|.|||||::|.:.|::||||||||||:|||.||||||.||::||.||:..||||.||||||
Mouse   269 LDGDVTDVVEAKSLGIRPNYIDIYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVW 333

  Fly   557 ASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVD 621
            |||||||..|.|:||||||||:|:|:||.|:.|.||||||||:||||||||||. .:::.:.|.|
Mouse   334 ASGNGGREGDHCSCDGYTNSIYTISVSSTTENGHKPWYLEECASTLATTYSSGA-FYERKIVTTD 397

  Fly   622 MDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTL 686
            :      ...||..|||||.|||:.|||.|||||||.:|||||:|:|:|.|||||.| |.:.|.:
Mouse   398 L------RQRCTDGHTGTSVSAPMVAGIIALALEANNQLTWRDVQHLLVKTSRPAHL-KASDWKV 455

  Fly   687 NGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHMDVNGC 751
            ||...|.||.:|:||:||.|:|..|.:||:||.||:|.:..:...|.|  .....|.|....|.|
Mouse   456 NGAGHKVSHLYGFGLVDAEALVLEARKWTAVPSQHVCVATADKRPRSI--PIVQVLRTTALTNAC 518

  Fly   752 AGTINE-VRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHF 815
            |...:: |.|||||..||::....||:|:|.|.||.||.|.||.:|..|.....|.:|.|::||.
Mouse   519 ADHSDQRVVYLEHVVVRISISHPRRGDLQIHLISPSGTKSQLLAKRLLDFSNEGFTNWEFMTVHC 583

  Fly   816 WGEKAEGRWTLQV--INGGRRRVNQPGILSKWQLIFYGTSTQPMRL------KSELLNSSPQLRS 872
            |||||||.|||:|  |....|...:.|.|.:|.||.|||:..|.|.      :|.:|    :|..
Mouse   584 WGEKAEGEWTLEVQDIPSQVRNPEKQGKLKEWSLILYGTAEHPYRTFSSHQSRSRML----ELSV 644

  Fly   873 PSSSNPFLFPSASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQNVTAAIAG 937
            |....|                                  .:||..|:..|.. |.:..||....
Mouse   645 PEQEPP----------------------------------KAAGQPPQAETPE-DEEEYTAPSIQ 674

  Fly   938 GSSAESLGFTASAAQLVAAPETRDGDKKILHSCDAECDSSGCYGRGPTQCVACSHYRLDNT---- 998
            ||                 |.|..     ...|..||...||.|....||:.|.|:.|.|:
Mouse   675 GS-----------------PNTLQ-----TSVCHPECGDKGCDGPNADQCLNCVHFSLGNSKTNR 717

  Fly   999 -CVSRCPPRSFPNQVG-ICWPCHDTCETCAGAGPDSCLTCAPAHLHVIDLAVCLQFCPDGYFENS 1061
             |||.||...|.:... .|..||..||||.|..|..||:|.....|..:...|:..||.|.:.:.
Mouse   718 KCVSECPLGYFGDAAARRCRRCHKGCETCTGRSPAQCLSCRRGFYHHQETNTCVTLCPAGLYADE 782

  Fly  1062 RNRTCVPCEPNCASCQDHPEYCTSCDHHLVMHEHKCYSACPLDTY-ETEDNKCAFCHSTCATCNG 1125
            ..|.|:.|.|:|..|.|.||.||.|.....:....|...|...|| ::|..||..||.||.||.|
Mouse   783 SQRLCLRCHPSCQKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELVKCGECHHTCRTCVG 847

  Fly  1126 PTDQDCITCRSSRYAWQNKCLISCPDGFYADK----KRLECMPCQEGCKTCT-SNGVCSECLQNW 1185
            |:.::||.|..|.:....||:.:|.:|||.::    ....|..|:|.|.:|. |:..||.|...:
Mouse   848 PSREECIHCAKSFHFQDWKCVPACGEGFYPEEMPGLPHKVCRRCEENCLSCEGSSRNCSRCKAGF 912

  Fly  1186 TLNKRDKCIVSGSEGCSESEFYSQVEGQCRPCHASCGSCNGPADTSCTSCPPNRLLEQSRCVSGC 1250
            |                      |:...|...|    :|:...:|.|.....|||.|:...:..|
Mouse   913 T----------------------QLGTSCITNH----TCSNADETFCEMVKSNRLCERKLFIQFC 951

  Fly  1251 REGFFVEAGSLCSPCL 1266
                       |..||
Mouse   952 -----------CRTCL 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	34/75 (45%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	188/300 (63%)
		Peptidase_S8	411..700	CDD:278510	188/290 (65%)
		P_proprotein	761..849	CDD:279782	42/89 (47%)
		Furin-like	966..1126	CDD:279142	60/166 (36%)
		FU	970..1013	CDD:238021	18/47 (38%)
		FU	1017..1067	CDD:238021	17/49 (35%)
		FU	1063..1106	CDD:214589	14/42 (33%)
		GF_recep_IV	1068..1232	CDD:291509	50/169 (30%)
		FU	1116..1163	CDD:238021	18/50 (36%)
		FU	1211..1255	CDD:214589	10/43 (23%)
		FU	1259..1301	CDD:214589	3/8 (38%)
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
Pcsk6	NP_035178.1	S8_pro-domain	65..141	CDD:293079	34/75 (45%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	150..444	CDD:173789	188/300 (63%)
		Peptidase_S8	186..469	CDD:278510	188/290 (65%)
		P_proprotein	529..619	CDD:279782	42/89 (47%)
		FU	685..737	CDD:238021	18/51 (35%)
		FU	733..779	CDD:214589	17/45 (38%)
		Furin-like_2	741..837	CDD:292535	33/95 (35%)
		FU	787..827	CDD:214589	13/39 (33%)
		FU	834..876	CDD:214589	18/41 (44%)
		PLAC	932..955	CDD:285849	7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833561
Domainoid	1	1.000	92	1.000	Domainoid score	I7584
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52598
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		otm43363
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4577
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690