DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and Pcsk5

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_001177412.1	Gene:	Pcsk5 / 18552	MGIID:	97515	Length:	1877	Species:	Mus musculus

Alignment Length:	1944	Identity:	582/1944 - (29%)
Similarity:	760/1944 - (39%)	Gaps:	714/1944 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 IYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSEN 302
            :|||.:||.|..|...||.||:|:||||.||||:|.:||.|.|....|||:.|||.....:..|.
Mouse    36 VYTNHWAVKIAGGFAEADRIASKYGFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEP 100

  Fly   303 EVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYR 367
            :|:|:|||..|.|.|||           |:|                         ||:|
Mouse   101 KVEWIQQQVVKKRTKRD-----------YDL-------------------------SHAQ----- 124

  Fly   368 DVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQ 432
              |::  |.||.:...||:...:.......|||:..||::|||||.:||:||||||:..||||.|
Mouse   125 --STY--FNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQ 185

  Fly   433 NYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK 495
            |||..||.|:||||.||.|:  .:.:|||||||||||||.|.|:.|.||:|:||.|||||||||.
Mouse   186 NYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGD 250

  Fly   496 VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGN 560
            |.|:|||:::|.||.|:.||||||||:|||.|||||.||.|:||..||..||:|.||:|||||||
Mouse   251 VTDMVEAKSVSYNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGN 315

  Fly   561 GGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGS 625
            |||..|.|:||||||||:|:||||..::|.||||||||||||||||||| ..:||.:.|.|:
Mouse   316 GGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSG-ESYDKKIITTDL--- 376

  Fly   626 LRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNGVK 690
               ...||..|||||||||:||||.||||||||.|||||:|:::|.|||...| ..|.|..|...
Mouse   377 ---RQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHL-NANDWKTNAAG 437

  Fly   691 RKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAY-GSTLSTHMDVNGCAGT 754
            .|.||.:|:|||||.|||..||:||:||.||:|   ..:.||:|.... .|.:.:....:||:..
Mouse   438 FKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVC---VESTDRQIKTIRPNSAVRSIYKASGCSDN 499

  Fly   755 IN-EVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHFWGE 818
            .| .|.|||||..|||:....||:|.|.||||.||.|.||..|..|.....|.:|.|:::|.|||
Mouse   500 PNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGE 564

  Fly   819 KAEGRWTLQVIN--GGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSSPQLRSPSSSNP--- 878
            :|.|.|.|:|.:  ...|....||.|.:|.|:.||||.||.              ||::..|
Mouse   565 RAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPY--------------SPTNEFPKVE 615

  Fly   879 -FLF--------------------PSASNIG--QPANE------------------------GGN 896
             |.:                    |..|.:|  .|..:                        .|:
Mouse   616 RFRYSRVEDPTDDYGAEDYAGPCDPECSEVGCDGPGPDHCSDCLHYYYKLKNNTRICVSSCPPGH 680

  Fly   897 FNTD-------------------------SFASYLN--------------YQNIFSS-AGSDPEP 921
            ::.|                         .:..:||              |::|..: .|...|.
Mouse   681 YHADKKRCRKCAPNCESCFGSHGNQCLSCKYGYFLNEETSSCVTQCPDGSYEDIKKNVCGKCSEN 745

  Fly   922 ATATLDGQNVT----------------------------------AAIAGGSSAESL-----GFT 947
            ..|.:...|.|                                  .|...|:.|:..     |:.
Mouse   746 CKACIGFHNCTECKGGLSLQGSRCSVTCEDGQFFNGHDCQPCHRFCATCSGAGADGCINCTEGYV 810

  Fly   948 ASAAQLVAA-------PETRDGDKKILHSCDAEC------------------------------- 974
            ....:.|.:       ..:.:|..|....||..|
Mouse   811 MEEGRCVQSCSVSYYLDHSSEGGYKSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGTCQMGAIC 875

  Fly   975 ------DSSG-----------CYGRGPTQ--CVACSHYRL--DNTCVSRCPPRSFPNQVGICWPC 1018
                  |..|           |:  ||||  |::|...|:  |..||..||...|..:.. |.||
Mouse   876 KDGEYIDDQGHCQTCEASCAKCW--GPTQEDCISCPVTRVLDDGRCVMNCPSWKFEFKKQ-CHPC 937

  Fly  1019 HDTCETCAGAGPDSCLTCA------------------------PAHLHVIDLAVCLQFCPD---- 1055
            |.||:.|.|:||.:|.:|.                        ||..|     .||. |||
Mouse   938 HYTCQGCQGSGPSNCTSCRADKHGQERFLYHGECLENCPVGHYPAKGH-----ACLP-CPDNCEL 996

  Fly  1056 ------------------------------GYFENSRNRTCVPCEPNCASC-QDHPEYCTSCDHH 1089
                                          |.|::|....|:|||..|..| :|.|..||||...
Mouse   997 CYNPHVCSRCMSGYVIIPPNHTCQKLECRQGEFQDSEYEECMPCEEGCLGCTEDDPGACTSCATG 1061

  Fly  1090 LVMHEHKCYSACPLDT----------------------YETED---------------------- 1110
            ..|.|..||.|||..|                      |..|:
Mouse  1062 YYMFERHCYKACPEKTFGVKWECRACGTNCGSCDQHECYWCEEGFFLSGGSCVQDCGPGFHGDQE 1126

  Fly  1111 -------------------NKCAF----------------------------------------- 1115
                               |:|:.
Mouse  1127 LGECKPCHRACENCTGSGYNQCSSCQEGLQLWHGTCLWSTWPQVEGKDWNEAVPTEKPSLVRSLL 1191

  Fly  1116 --------------------CHSTCATCNGPTDQDCITCRSSRYAWQNKCLISCPDGFYADKKRL 1160
                                |||:|.||||..   |.:|.:..|.|...|:.|||.|.:......
Mouse  1192 QDRRKWKVQIKRDATSQNQPCHSSCKTCNGSL---CASCPTGMYLWLQACVPSCPQGTWPSVTSG 1253

  Fly  1161 ECMPCQEGCKTCTSNGVCSECL---QNWTLNKRDKCIVSGSEG----------CS---------- 1202
            .|..|.|.|.:|:...:|.:||   .|..|....:|..|..||          ||
Mouse  1254 SCEKCSEDCVSCSGADLCQQCLSQPDNTLLLHEGRCYHSCPEGFYAKDGVCEHCSSPCKTCEGNA 1318

  Fly  1203 ------ESEF--------------YSQVEG----------------------------------- 1212
                  |.:|              :..|||
Mouse  1319 TSCNSCEGDFVLDHGVCWKTCPEKHVAVEGVCKHCPERCQDCIHEKTCKECMPDFFLYNDMCHRS 1383

  Fly  1213 ----------QCRPCHASCGSCNGP--------ADTS------------------------CTSC 1235
                      ||.|||.:|..||||        ||||                        |..|
Mouse  1384 CPKSFYPDMRQCVPCHKNCLECNGPKEDDCKVCADTSKALHNGLCLDECPEGTYKEEENDECRDC 1448

  Fly  1236 PPNRLLEQS--RCVSGCREGFFV------------------EAGSLCSPCLHTCSQC--VSRTNC 1278
            |.:.|:..|  .|:: |||||.|                  |....|.||...||:|  .|...|
Mouse  1449 PESCLICSSAWTCLA-CREGFTVVHDVCTAPKECAAVEYWDEGSHRCQPCHKKCSRCSGPSEDQC 1512

  Fly  1279 SNCSKGLELQNGECRTTCADGYYSDRGI--CAKCYLSCHTCSGPRRNQCVQCPAGWQLAAGECHP 1341
            ..|.:...|.|..|...|.:||::|:..  |..|:.||.||.||...||:.|..||.....||..
Mouse  1513 YTCPRETFLLNTTCVKECPEGYHTDKDSQQCVLCHSSCRTCEGPHSMQCLSCRPGWFQLGKECLL 1577

  Fly  1342 ECPEGFY-KSDFG-CQKCHHYCKTCNDAGPLACTS-----------------CPPHSMLD----- 1382
            :|.:|:| :|..| |:||...||:|....|..|.|                 ||.|...|
Mouse  1578 QCRDGYYGESTSGRCEKCDKSCKSCRGPRPTDCQSCDTFFFLLRSKGQCHRACPEHYYADQHAQT 1642

  Fly  1383 -----------------------------GGLCM-ECLSSQYYD--TTSATCKTCHDSCRSCFGP 1415
                                         .|:|: ||:..:|.:  ..:..||.||:||..|.||
Mouse  1643 CERCHPTCDKCSGKEAWSCLSCVWSYHLLKGICIPECIVGEYREGKGENFNCKKCHESCMECKGP 1707

  Fly  1416 GQFSCKGCVPPLHLDQLNSQCVSCCQNQTLAEKTSSAACCNCDGETGECKATSTGGKRRTVVGSG 1480
            |..:|.||...|.||..:::|:.||   ..:....|..||:|...|.||           ::.:.
Mouse  1708 GSKNCTGCSAGLLLDMDDNRCLHCC---NASHSRRSQDCCDCQSSTDEC-----------ILPAR 1758

  Fly  1481 SAYKSSESKHGSFENDGNAREFVLRLDSPLTAITAIAVAICLLIITIFSIIFAVLQRNSNHVSRN 1545
            .|.....:|                     ||:...:.|:.||::...::::.  :..|..|::.
Mouse  1759 EAEFYEHTK---------------------TALLVTSGAMLLLLLGAAAVVWR--KSRSRPVAKG 1800

  Fly  1546 SVRYRKIA----NTSSGRRKNLSAKPTSDARFIFNIGEDDDTDGDNSDDEL----DGNV 1596
              ||.|:|    :.||.|...|......:.|       |.|.|.|:.||.:    ||.|
Mouse  1801 --RYEKLAEPTVSYSSYRSSYLDEDQVIEYR-------DRDYDEDDEDDIVYMGQDGTV 1850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	36/75 (48%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	188/300 (63%)
		Peptidase_S8	411..700	CDD:278510	185/290 (64%)
		P_proprotein	761..849	CDD:279782	40/89 (45%)
		Furin-like	966..1126	CDD:279142	73/394 (19%)
		FU	970..1013	CDD:238021	19/94 (20%)
		FU	1017..1067	CDD:238021	22/107 (21%)
		FU	1063..1106	CDD:214589	20/65 (31%)
		GF_recep_IV	1068..1232	CDD:291509	75/408 (18%)
		FU	1116..1163	CDD:238021	17/46 (37%)
		FU	1211..1255	CDD:214589	26/122 (21%)
		FU	1259..1301	CDD:214589	14/43 (33%)
		FU	1304..1348	CDD:214589	17/45 (38%)
		FU	1356..1403	CDD:238021	17/100 (17%)
		FU	1401..1444	CDD:214589	19/42 (45%)
Pcsk5	NP_001177412.1	S8_pro-domain	40..116	CDD:293079	36/75 (48%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	128..422	CDD:173789	188/300 (63%)
		Peptidase_S8	164..447	CDD:278510	185/290 (64%)
		P_proprotein	507..597	CDD:279782	40/89 (45%)
		Cell attachment site. /evidence=ECO:0000255	521..523		1/1 (100%)
		FU 1	632..682		5/49 (10%)
		FU	637..687	CDD:238021	6/49 (12%)
		CRM (Cys-rich motif)	638..1753		231/1130 (20%)
		FU	690..739	CDD:238021	4/48 (8%)
		Furin-like_2	695..786	CDD:292535	9/90 (10%)
		FU	781..825	CDD:214589	5/43 (12%)
		GF_recep_IV	786..906	CDD:291509	17/121 (14%)
		FU	835..880	CDD:214589	4/44 (9%)
		FU	885..928	CDD:214589	14/44 (32%)
		FU	931..980	CDD:214589	12/49 (24%)
		FU	1036..1078	CDD:214589	19/41 (46%)
		Furin-like_2	1043..1130	CDD:292535	18/86 (21%)
		FU	1128..1165	CDD:214589	2/36 (6%)
		FU	1211..1256	CDD:238021	17/47 (36%)
		Furin-like_2	1214..1305	CDD:292535	29/93 (31%)
		FU	1301..1343	CDD:214589	4/41 (10%)
		Furin-like_2	1357..1445	CDD:292535	14/87 (16%)
		FU	1397..1446	CDD:238021	12/48 (25%)
		FU	1491..1535	CDD:214589	14/43 (33%)
		GF_recep_IV	1496..1611	CDD:291509	42/114 (37%)
		FU	1546..1593	CDD:238021	19/46 (41%)
		FU	1594..1644	CDD:238021	12/49 (24%)
		GF_recep_IV	1595..1712	CDD:291509	26/116 (22%)
		FU	1642..1684	CDD:214589	4/41 (10%)
		FU	1694..1736	CDD:214589	19/44 (43%)
		AC 1	1825..1844		7/25 (28%)
		AC 2	1856..1877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2589
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21244
Inparanoid	1	1.050	771	1.000	Inparanoid score	I534
Isobase	1	0.950	-	0	Normalized mean entropy	S3236
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		otm43363
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4005
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.720