Protein Alignment Fur2 and Furin

DIOPT Version :10

• Sequence 1: NP_727963.1
• Gene: Fur2 / 32604
• FlyBaseID: FBgn0004598
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: XP_011249120.1
• Gene: Furin / 18550
• MGIID: 97513
• Length: 803
• Species: Mus musculus
• Alignment Length: 838
• Identity: 366/838 - (43%)
• Similarity: 428/838 - (51%)
• Gaps: 222/838 - (26%)

  Fly   236 EAIYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKS 300
            :.|:||.:||:||.|..:||.:|.||||.|.|||  ..:||.|.|..|:||||...|.....|:.
Mouse    27 QKIFTNTWAVHIPGGPAVADRVAQKHGFHNLGQI--FGDYYHFWHRAVTKRSLSPHRPRHSRLQR 89

  Fly   301 ENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRME 365
            |.:|||::||..|.|.||| .||: ||
Mouse    90 EPQVKWLEQQVAKRRAKRD-VYQE-PT-------------------------------------- 114

  Fly   366 YRDVSSHFIFPDPLFKEQWYLVSKNGGAKDGL---DMNVGPAWQKGYTGKGVVVSILDDGIQTNH 427
                       ||.|.:||||        .|:   |:||..||.:|:||.|:|||||||||:.||
Mouse   115 -----------DPKFPQQWYL--------SGVTQRDLNVKEAWAQGFTGHGIVVSILDDGIEKNH 160

  Fly   428 PDLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIG--- 487
            ||||.||||.||||:|..|.||.|:  ...||:|||||||||||||.|..|||||||||.||
Mouse   161 PDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGAPL 225

  Fly   488 -------GVRMLDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTS 545
                   |||||||:|.|.|||::|.|||:||.||||||||||||.|||||..||..||..||:.
Mouse   226 FPPPLRPGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQ 290

  Fly   546 GRQGKGSIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGT 610
            ||.|.|||||||||||||..||||||||||||:|||||||||.|..|||.|.||||||||||||.
Mouse   291 GRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGN 355

  Fly   611 PGHDKSVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRP 675
            . ::|.:.|.|:...      ||..||||||||||||||.||.||||..|||||||:|||.||:|
Mouse   356 Q-NEKQIVTTDLRQK------CTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKP 413

  Fly   676 APLEKENGWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGS 740
            |.|..:: |..|||.||.||.:||||:||||||:||:.||:|.||..|......|.:.|    |.
Mouse   414 AHLNADD-WATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVEPKDI----GK 473

  Fly   741 TLSTHMDVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNF 805
            .|.....|..|.|..|.:..|||||.|:||.:..||:|.|.|.|||||.||||..||.|.....|
Mouse   474 RLEVRKAVTACLGEPNHITRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGF 538

  Fly   806 DDWPFLSVHFWGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSSPQL 870
            :||.|::.|.|.|...|.|.|::.|  ....|..|.|:|:.|:.|||
Mouse   539 NDWAFMTTHSWDEDPAGEWVLEIEN--TSEANNYGTLTKFTLVLYGT------------------ 583

  Fly   871 RSPSSSNPFLFPSASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQNVTAAI 935
                                |.||
Mouse   584 --------------------APEG----------------------------------------- 587

  Fly   936 AGGSSAESLGFTASAAQLVAAPETRDGDKKILHSCDAECDSSGCYGRGPTQ-CVACSH-YRL-DN 997
                             |...||                 ||||.....:| ||.|.. |.| ..
Mouse   588 -----------------LSTPPE-----------------SSGCKTLTSSQACVVCEEGYSLHQK 618

  Fly   998 TCVSRCPPRSFPN---------------QVGICWPCHDTCETCAGAGPDSCLTCAPAH 1040
            :||..|||...|.               :..:|.|||.:|.||.|..|..||:| |:|
Mouse   619 SCVQHCPPGFIPQVLDTHYSTENDVEIIRASVCTPCHASCATCQGPAPTDCLSC-PSH 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:465126	35/75 (47%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	375..674	CDD:173789	203/313 (65%)
		P_proprotein	761..849	CDD:460225	41/87 (47%)
		GF_recep_IV	970..1073	CDD:464344	30/89 (34%)
		VSP	1020..1379	CDD:146106	10/21 (48%)
		FU	1401..1444	CDD:214589
Furin	XP_011249120.1	S8_pro-domain	33..107	CDD:465126	35/75 (47%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	113..412	CDD:173789	205/362 (57%)
		P_proprotein	494..580	CDD:460225	41/87 (47%)
		FU	591..629	CDD:214589	17/54 (31%)
		FU	648..>685	CDD:214589	14/29 (48%)