DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and Pcsk1

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_038656.1	Gene:	Pcsk1 / 18548	MGIID:	97511	Length:	753	Species:	Mus musculus

Alignment Length:	641	Identity:	299/641 - (46%)
Similarity:	400/641 - (62%)	Gaps:	60/641 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 SIPEEAIYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQG 296
            |:..:..:.||:|..||.|::.|..||.:.|:...||||||:|:|||:|....:||.||:.....
Mouse    24 SVKAKRQFVNEWAAEIPGGQEAASAIAEELGYDLLGQIGSLENHYLFKHKSHPRRSRRSALHITK 88

  Fly   297 ALKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHS 361
            .|..::.|.|.:||:||.|.||.                      |..:..|.
Mouse    89 RLSDDDRVTWAEQQYEKERSKRS----------------------VQKDSALD------------ 119

  Fly   362 QRMEYRDVSSHFIFPDPLFKEQWYLV-SKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQT 425
                        :|.||::.:||||. ::...|...||::|.|.|:||.||||||:::||||::.
Mouse   120 ------------LFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWEKGITGKGVVITVLDDGLEW 172

  Fly   426 NHPDLAQNYDPEASFDINGNDSDPTPQDN--GDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGG 488
            ||.|:..|||||||:|.|.||.||.|:.:  .:||||||||||:|..|.|:.||||||||:.:||
Mouse   173 NHTDIYANYDPEASYDFNDNDHDPFPRYDLTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGG 237

  Fly   489 VRMLDGKVNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSI 553
            :|||||.|.|.:||.::..||.|:|||||||||.|||.||:|||.||::||.|||..||||||||
Mouse   238 IRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSI 302

  Fly   554 FVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVA 618
            ||||||||||..|:|:|||||:||:|:|||||:|.|..|||.|:|||||||:|||| ...|:.:.
Mouse   303 FVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSG-DYTDQRIT 366

  Fly   619 TVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENG 683
            :.|:...      ||..||||||||||||||.||||||||.|||||||:|||:||...||....|
Mouse   367 SADLHND------CTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLASNPG 425

  Fly   684 WTLNGVKRKYSHKFGYGLMDAGAMVSLAE--QWTSVPPQHICKSRENNEDRKIDGAYGSTLSTHM 746
            |..||.....:.:||:||::|.|:|.||:  .|.:||.:..|..::||.:.:...|.|..: ..:
Mouse   426 WKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRNVPEKKECVVKDNNFEPRALKANGEVI-VEI 489

  Fly   747 DVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFL 811
            ....|.|..|.::.|||||...|:.:..||:|.:.|||.:||::.||.||.||...:.|.:|.|:
Mouse   490 PTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAVGTSTVLLAERERDTSPNGFKNWDFM 554

  Fly   812 SVHFWGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSS 867
            |||.|||...|.|||::.:...|..|: |.:..|:||.:|||:||..:|...:.:|
Mouse   555 SVHTWGENPVGTWTLKITDMSGRMQNE-GRIVNWKLILHGTSSQPEHMKQPRVYTS 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	32/75 (43%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	188/301 (62%)
		Peptidase_S8	411..700	CDD:278510	181/290 (62%)
		P_proprotein	761..849	CDD:279782	38/87 (44%)
		Furin-like	966..1126	CDD:279142
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
Pcsk1	NP_038656.1	S8_pro-domain	34..110	CDD:374560	32/75 (43%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	121..415	CDD:173789	187/300 (62%)
		P_proprotein	504..591	CDD:366670	38/87 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	633..663
		Proho_convert	715..751	CDD:371942
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720