DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and egl-3

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_001023732.1	Gene:	egl-3 / 179412	WormBaseID:	WBGene00001172	Length:	652	Species:	Caenorhabditis elegans

Alignment Length:	661	Identity:	271/661 - (40%)
Similarity:	358/661 - (54%)	Gaps:	95/661 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 IYTNEFAVNIPAGKQMADV--IATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKS 300
            :|||.|.|::..|..:.|.  ||.:||||||||:.:.||.|.|....:.....|.|..|...|.:
Worm    25 VYTNHFHVHLKEGGGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRSAGHHAKLHN 89

  Fly   301 ENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRME 365
            ::||..::|.....|.||.        |.|.                             .||:|
Worm    90 DDEVLHVEQLKGYTRTKRG--------YRPL-----------------------------EQRLE 117

  Fly   366 YR-DVSSHFIFPDPLFKEQWYLVSKN---GGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTN 426
            .: |.|:.....|||:..||||  ||   .|.|..||:||..||..|:|||.:..:|:|||:...
Worm   118 SQFDFSAVMSPSDPLYGYQWYL--KNTGQAGGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYM 180

  Fly   427 HPDLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGV 489
            |||:..|::.|||:|.:.||..|.|:  |:..|.||||||||:.|...|..|||||||:..:.|:
Worm   181 HPDIKNNFNAEASYDFSSNDPFPYPRYTDDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGI 245

  Fly   490 RMLDGK-VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSI 553
            ||||.. :.|::||.::...||.|.||||||||.|||.|||||.....||.:.||..||.|.|||
Worm   246 RMLDQPYMTDLIEANSMGHEPSKIHIYSASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSI 310

  Fly   554 FVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVA 618
            ||||||:||. .|.||||||..|::|:||:||...|....|.|.||||||:|:|:|....:..||
Worm   311 FVWASGDGGE-DDDCNCDGYAASMWTISINSAINNGENAHYDESCSSTLASTFSNGGRNPETGVA 374

  Fly   619 TVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPL----- 678
            |.|:.|.      ||..|:||||:||.|||:.||||||||.|||||:|:|.|.||....|
Worm   375 TTDLYGR------CTRSHSGTSAAAPEAAGVFALALEANPSLTWRDLQHLTVLTSSRNSLFDGRC 433

  Fly   679 ------------EKENG------WTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKS 725
                        ...:|      |.:|||..:|:|.||:|::||..||.||..|.:.||::.|.:
Worm   434 RDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYNHLFGFGVLDAAEMVMLAMAWKTSPPRYHCTA 498

  Fly   726 RENNEDRKI--DGAYGSTLSTHMDVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGT 788
            ...:...:|  ||    .|...::.:||||:..|||||||||..::.....||:..:.|.|||||
Worm   499 GLIDTPHEIPADG----NLILEINTDGCAGSQFEVRYLEHVQAVVSFNSTRRGDTTLYLISPMGT 559

  Fly   789 TSTLLFERPR-DIVKSNFDDWPFLSVHFWGEKAEGRWTLQVINGGRRRVNQP----GILSKWQLI 848
            .:.:|..||: |..|..|.:|||::.|.|||...|:|.|..      |...|    |.|.|::|:
Worm   560 RTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTGKWRLVA------RFQGPGAHAGTLKKFELM 618

  Fly   849 FYGTSTQPMRL 859
            .:||...|..|
Worm   619 LHGTREAPYNL 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	26/77 (34%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	160/304 (53%)
		Peptidase_S8	411..700	CDD:278510	152/314 (48%)
		P_proprotein	761..849	CDD:279782	35/92 (38%)
		Furin-like	966..1126	CDD:279142
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
egl-3	NP_001023732.1	S8_pro-domain	29..107	CDD:318632	26/77 (34%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	128..423	CDD:173789	159/303 (52%)
		P_proprotein	532..619	CDD:307572	35/92 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920