DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and Pcsk5

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	XP_038965620.1	Gene:	Pcsk5 / 116548	RGDID:	620326	Length:	1878	Species:	Rattus norvegicus

Alignment Length:	1938	Identity:	587/1938 - (30%)
Similarity:	761/1938 - (39%)	Gaps:	701/1938 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 IYTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSEN 302
            :|||.:||.|..|...||.||:|:||||.||||:|.:||.|.|....|||:.|||.....:..|.
  Rat    36 VYTNHWAVKIAGGFAEADRIASKYGFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEP 100

  Fly   303 EVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYR 367
            :|:|:|||..|.|.|||           |:|.|....|
  Rat   101 KVEWIQQQVVKKRTKRD-----------YDLSRAQSTY--------------------------- 127

  Fly   368 DVSSHFIFPDPLFKEQWYLVSKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQ 432
                   |.||.:...||:...:.......|||:..||::|||||.:||:||||||:..||||.|
  Rat   128 -------FNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQ 185

  Fly   433 NYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK 495
            |||..||.|:||||.||.|:  .:.:|||||||||||||.|.|:.|.||:|:||.|||||||||.
  Rat   186 NYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGD 250

  Fly   496 VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGN 560
            |.|:|||:::|.||.|:.||||||||:|||.|||||.||.|:||..||..||:|.||:|||||||
  Rat   251 VTDMVEAKSVSYNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGN 315

  Fly   561 GGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGS 625
            |||..|.|:||||||||:|:||||..::|.||||||||||||||||||| ..:||.:.|.|:
  Rat   316 GGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSG-ESYDKKIITTDL--- 376

  Fly   626 LRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNGVK 690
               ...||..|||||||||:||||.||||||||.|||||:|:::|.|||...| ..|.|..|...
  Rat   377 ---RQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHL-NANDWKTNAAG 437

  Fly   691 RKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAY-GSTLSTHMDVNGCAGT 754
            .|.||.:|:|||||.|||..||:||:||.||:|   ..:.||:|.... .|.:.:....:||:..
  Rat   438 FKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVC---VESTDRQIKTIRPNSAVRSIYKASGCSDN 499

  Fly   755 IN-EVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHFWGE 818
            .| .|.|||||..|||:....||:|.|.||||.||.|.||..|..|.....|.:|.|:::|.|||
  Rat   500 PNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGE 564

  Fly   819 KAEGRWTLQVIN--GGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSSPQLRSPSSSNP--- 878
            :|.|.|.|:|.:  ...|....||.|.:|.|:.||||.||.              ||::..|
  Rat   565 RAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPY--------------SPTNEFPKVE 615

  Fly   879 -FLF--------------------PSASNIG--QPANE------------------------GGN 896
             |.:                    |..|.:|  .|..:                        .|:
  Rat   616 RFRYSRVEDPTDDYGAEDYAGPCDPECSEVGCDGPGPDHCTDCLHYHYKLKNNTRICVSSCPPGH 680

  Fly   897 FNTD-------------------------SFASYLN--------------YQNIFSS-------- 914
            |:.|                         .:..:||              ||:|..:
  Rat   681 FHADKKRCRKCAPNCESCFGSHADQCLSCKYGYFLNEETSSCVAQCPEGSYQDIKKNICGKCSEN 745

  Fly   915 ----------------------------------AGSDPEP--------ATATLDG--------- 928
                                              :|.|.:|        |.|..||
  Rat   746 CKTCTGFHNCTECKGGLSLQGSRCSVTCEDGQFFSGHDCQPCHRFCATCAGAGADGCINCTEGYV 810

  Fly   929 -------QNVTA------AIAGG----------------------SSAESLGFTASAAQLVAAPE 958
                   |:.:.      ::.||                      ||..| |:............
  Rat   811 MEEGRCVQSCSVSYYLDHSLEGGYKSCKRCDNSCLTCNGPGFKNCSSCPS-GYLLDLGMCQMGAI 874

  Fly   959 TRDG----DKKILHSCDAECDSSGCYGRGPTQ--CVACSHYRL--DNTCVSRCPPRSFPNQVGIC 1015
            .:||    ::.....|||.|  :.|:  ||||  |::|...|:  |..||..||...|..:.. |
  Rat   875 CKDGEYIDEQGHCQICDASC--AKCW--GPTQDDCISCPITRVFDDGRCVMNCPSWKFELKKQ-C 934

  Fly  1016 WPCHDTCETCAGAGPDSCLTC-APAH--LHVIDLAVCLQFCPDGY-------------------- 1057
            .|||.||:.|.|:||.:|.:| |..|  .:.:....||:.||.|:
  Rat   935 HPCHHTCQGCQGSGPSNCTSCKADKHGQEYFLYKGECLENCPMGHYPAKGHACLPCPDNCELCYN 999

  Fly  1058 -----------------------------FENSRNRTCVPCEPNCASCQ-DHPEYCTSCDHHLVM 1092
                                         |::|....|:|||..|..|. |.|..||||.....|
  Rat  1000 PHVCSRCMSGYVIVPTNHTCQKLECRQGEFQDSEYGECMPCEEGCVGCTVDDPGACTSCATGYYM 1064

  Fly  1093 HEHKCYSACPLDTY---------------------------------------------ETEDNK 1112
            .|..||.|||..|:                                             :.|..:
  Rat  1065 FERHCYKACPEKTFGEKWECKACGTNCGSCDQHECYWCEEGFFLSSGSCVQDCDPGFYGDQELGE 1129

  Fly  1113 CAFCHSTCATCNG-------------------------------------PTD---------QD- 1130
            |..||..|.||.|                                     ||:         ||
  Rat  1130 CKPCHRACETCTGLGYNQCSSCPEGLQLWHGTCIWPTWPHVEGKVWNEAVPTEKPSLVRSLPQDR 1194

  Fly  1131 -----------------------------CITCRSSRYAWQNKCLISCPDGFYADKKRLECMPCQ 1166
                                         |.:|.:..|.|...|:.|||.|.:...:...|..|.
  Rat  1195 RKWKVQIKRDATRQYQPCHSSCKTCNGSLCTSCPAGTYLWLQACVPSCPQGTWLSVRSSSCEKCA 1259

  Fly  1167 EGCKTCTSNGVCSECL---QNWTLNKRDKCIVSGSEG----------CS---------------- 1202
            |||.:|:.:.:|..||   .|..|....:|..|..||          ||
  Rat  1260 EGCASCSGDDLCQRCLSQPSNTLLLHEGRCYHSCPEGFYAKDGVCEHCSSPCKTCKGNATSCHSC 1324

  Fly  1203 ESEF--------------YSQVEG----------------------------------------- 1212
            |.:|              :..|||
  Rat  1325 EGDFVLDHGVCWETCPEKHVAVEGVCKHCPERCQDCIHEKTCKECMPDFFLYNDMCHHSCPKNFY 1389

  Fly  1213 ----QCRPCHASCGSCNGP--------ADTS------------------------CTSCPPNRLL 1241
                ||.|||.:|..||||        ||||                        |..||.:.|:
  Rat  1390 PDMRQCVPCHKNCLGCNGPKEDDCKACADTSKVLHNGLCLDECPKGTYKDEVNDECRDCPESCLI 1454

  Fly  1242 EQS--RCVSGCREGFFV-----------------EAGS-LCSPCLHTCSQC--VSRTNCSNCSKG 1284
            ..|  .|:: |||||.|                 :.|| .|.||...||:|  .|...|..|.:.
  Rat  1455 CSSAWTCLT-CREGFTVVQDVCTAPKECAAIEYWDVGSHRCQPCHRKCSRCSGPSENQCYTCPRE 1518

  Fly  1285 LELQNGECRTTCADGYYSDRGI--CAKCYLSCHTCSGPRRNQCVQCPAGWQLAAGECHPECPEGF 1347
            ..|.|..|...|.:||::|:..  |..|:.||.||.||...||:.|..||.....||..:|.:|:
  Rat  1519 TFLLNTTCVKECPEGYHTDKDSHQCVPCHSSCRTCEGPHSMQCLSCRPGWFQLGKECLLQCRDGY 1583

  Fly  1348 Y-KSDFG-CQKCHHYCKTCNDAGPLACTS-----------------CPPHSMLD----------- 1382
            | :|..| |:||...||||....|..|.|                 ||.|...|
  Rat  1584 YGESTSGRCEKCDKSCKTCRGPQPTDCQSCDTFFFLLRSKGQCHLACPEHYYADQHAQTCERCHP 1648

  Fly  1383 -----------------------GGLCM-ECLSSQYYD--TTSATCKTCHDSCRSCFGPGQFSCK 1421
                                   .|:|. ||:..:|.|  ..:..||.||:||..|.|||..:|.
  Rat  1649 TCDKCSGKEAWNCLSCVWSYHLLKGICTPECIVGEYRDGKGENFNCKKCHESCMECKGPGSKNCT 1713

  Fly  1422 GCVPPLHLDQLNSQCVSCCQNQTLAEKTSSAACCNCDGETGECKATSTGGKRRTVVGSGSAYKSS 1486
            ||...|.|...:|:|:.||   ..:....|..||:|...|.||          .:..|.......
  Rat  1714 GCSAGLLLQMDDSRCLRCC---NASHPHRSQDCCDCQSSTDEC----------ILPASDDTVFHE 1765

  Fly  1487 ESKHGSFENDGNAREFVLRLDSPLTAITAIAVAICLLIITIFSIIFAVLQRNSNHVSRNSVRYRK 1551
            .:|                     ||:...:.|:.||::....:::.  :..|..|::.  ||.|
  Rat  1766 HTK---------------------TALLVTSGAMLLLLLGAAVVVWR--KSRSQPVAKG--RYEK 1805

  Fly  1552 IA----NTSSGRRKNLSAKPTSDARFIFNIGEDDDTDGDNSDDEL----DGNV 1596
            :|    :.||.|...|......:.|       |.|.|.|:.||.:    ||.|
  Rat  1806 LAEPTVSYSSYRSSYLDEDQVIEYR-------DRDYDEDDEDDIVYMGQDGTV 1851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	36/75 (48%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	188/300 (63%)
		Peptidase_S8	411..700	CDD:278510	185/290 (64%)
		P_proprotein	761..849	CDD:279782	40/89 (45%)
		Furin-like	966..1126	CDD:279142	67/298 (22%)
		FU	970..1013	CDD:238021	18/46 (39%)
		FU	1017..1067	CDD:238021	20/101 (20%)
		FU	1063..1106	CDD:214589	19/43 (44%)
		GF_recep_IV	1068..1232	CDD:291509	76/405 (19%)
		FU	1116..1163	CDD:238021	19/122 (16%)
		FU	1211..1255	CDD:214589	26/122 (21%)
		FU	1259..1301	CDD:214589	16/44 (36%)
		FU	1304..1348	CDD:214589	17/45 (38%)
		FU	1356..1403	CDD:238021	19/100 (19%)
		FU	1401..1444	CDD:214589	19/42 (45%)
Pcsk5	XP_038965620.1	S8_pro-domain	40..116	CDD:406785	36/75 (48%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	128..422	CDD:173789	188/300 (63%)
		P_proprotein	507..597	CDD:396185	40/89 (45%)
		GF_recep_IV	637..751	CDD:405525	12/113 (11%)
		VSP	674..>1063	CDD:146106	75/394 (19%)
		GF_recep_IV	889..995	CDD:405525	37/110 (34%)
		VSP	1003..>1324	CDD:146106	60/320 (19%)
		VSP	1293..>1618	CDD:146106	83/325 (26%)
		FU	1642..1684	CDD:214589	4/41 (10%)
		FU	1694..1737	CDD:214589	19/45 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2519
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21244
Inparanoid	1	1.050	779	1.000	Inparanoid score	I500
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		otm45432
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4005
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.770