DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and pcsk1

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	XP_004910515.3	Gene:	pcsk1 / 100496933	XenbaseID:	XB-GENE-983314	Length:	852	Species:	Xenopus tropicalis

Alignment Length:	743	Identity:	317/743 - (42%)
Similarity:	419/743 - (56%)	Gaps:	105/743 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 YTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSENE 303
            |.||:|..||.|.:.|.::|.:..:...||||||:|:|||:|....:||.||:......|..:..
Frog   142 YMNEWAAEIPGGPEEAQLLALELDYDYLGQIGSLENHYLFRHKAHPRRSRRSAPHLTKRLADDGR 206

  Fly   304 VKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYRD 368
            |.|.:||:.|.|.||....||...
Frog   207 VSWAEQQYSKERNKRSTFRQDTKN----------------------------------------- 230

  Fly   369 VSSHFIFPDPLFKEQWYLV-SKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQ 432
                 :|.|||:..||||. :::..:...||:::.|.|:||.||||||:::||||::.||.|:..
Frog   231 -----LFNDPLWNRQWYLQDTRSNPSLPKLDLHLLPVWKKGITGKGVVITVLDDGLEWNHTDIYA 290

  Fly   433 NYDPEASFDINGNDSDPTPQDN--GDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK 495
            |||||||:|.|.||:||.|:.:  .:|:||||||||:|.||.||.|||||||||.:||:|||||.
Frog   291 NYDPEASYDFNDNDNDPFPRYDITNENRHGTRCAGEIAMVANNNKCGVGVAYNAKVGGIRMLDGV 355

  Fly   496 VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGN 560
            |.|..||.::..||.|:.||||||||.|||.||:|||.||::||.||:..||.||||||||||||
Frog   356 VTDAKEASSIGFNPQHVHIYSASWGPNDDGKTVEGPGRLAQKAFEYGIKQGRNGKGSIFVWASGN 420

  Fly   561 GGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGS 625
            |||..|:|:|||||:||:|:|||||:|.|..|||.|:|||||||.|||| ...|:.:.:.|:...
Frog   421 GGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATAYSSG-DYTDQRIISADLHNE 484

  Fly   626 LRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNGVK 690
                  ||..||||||||||||||.|||||.||:|||||||:|||:||...||....||..||..
Frog   485 ------CTETHTGTSASAPLAAGIFALALEFNPDLTWRDMQHLVVWTSEYDPLANNAGWKKNGAG 543

  Fly   691 RKYSHKFGYGLMDAGAMVSLAE--QWTSVPPQHICKSRENNEDRKI---DGAYGSTLSTHMDVNG 750
            ...:.:||:||::|.|:|.||:  .|..|..:..|...:|....:.   ||    .::..:....
Frog   544 LMVNSRFGFGLLNAKALVDLADPKTWKGVAEKKECIVEDNEFSPRFLRSDG----EVTIQIPTKA 604

  Fly   751 CAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHF 815
            |.|..|.::.|||:|...|:.:..||:|.|.||||:||.:.||.||.||.....|..|.|:|||.
Frog   605 CEGQDNHIKSLEHLQLEATIEYTRRGDLHITLTSPLGTNTVLLTERERDTSPYGFKSWDFMSVHT 669

  Fly   816 WGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSSPQLRSPSSSNPFL 880
            |||...|.|||::.:...|:.|:..|:| |:||.:||||||..:|                :|.:
Frog   670 WGEDPAGTWTLKISDVSGRKKNEGRIVS-WKLILHGTSTQPEHMK----------------HPRV 717

  Fly   881 FPSASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSD-PEPATATLDGQNVTAAIAGGSSAESL 944
            :.| .|:.|....|.....|     :..:.|..|..:: ||....|.|.|.      ....|:||
Frog   718 YTS-YNVVQNDRRGAEKMDD-----IEKEPISESFTTERPEVTKNTPDSQE------AAERAKSL 770

  Fly   945 GFTASAAQLVAAPETRDG------DKKI 966
                :.|.|:.....|||      ||.|
Frog   771 ----AIAHLLKNAFDRDGGSFPLEDKDI 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	29/75 (39%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	185/301 (61%)
		Peptidase_S8	411..700	CDD:278510	179/290 (62%)
		P_proprotein	761..849	CDD:279782	40/87 (46%)
		Furin-like	966..1126	CDD:279142	1/1 (100%)
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
pcsk1	XP_004910515.3	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8145
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010