Protein Alignment Fur2 and pcsk1

DIOPT Version :10

• Sequence 1: NP_727963.1
• Gene: Fur2 / 32604
• FlyBaseID: FBgn0004598
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: XP_004910515.3
• Gene: pcsk1 / 100496933
• XenbaseID: XB-GENE-983314
• Length: 852
• Species: Xenopus tropicalis
• Alignment Length: 743
• Identity: 317/743 - (42%)
• Similarity: 419/743 - (56%)
• Gaps: 105/743 - (14%)

  Fly   239 YTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSENE 303
            |.||:|..||.|.:.|.::|.:..:...||||||:|:|||:|....:||.||:......|..:..
 Frog   142 YMNEWAAEIPGGPEEAQLLALELDYDYLGQIGSLENHYLFRHKAHPRRSRRSAPHLTKRLADDGR 206

  Fly   304 VKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYRD 368
            |.|.:||:.|.|.||....||...
 Frog   207 VSWAEQQYSKERNKRSTFRQDTKN----------------------------------------- 230

  Fly   369 VSSHFIFPDPLFKEQWYLV-SKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQ 432
                 :|.|||:..||||. :::..:...||:::.|.|:||.||||||:::||||::.||.|:..
 Frog   231 -----LFNDPLWNRQWYLQDTRSNPSLPKLDLHLLPVWKKGITGKGVVITVLDDGLEWNHTDIYA 290

  Fly   433 NYDPEASFDINGNDSDPTPQDN--GDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK 495
            |||||||:|.|.||:||.|:.:  .:|:||||||||:|.||.||.|||||||||.:||:|||||.
 Frog   291 NYDPEASYDFNDNDNDPFPRYDITNENRHGTRCAGEIAMVANNNKCGVGVAYNAKVGGIRMLDGV 355

  Fly   496 VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGN 560
            |.|..||.::..||.|:.||||||||.|||.||:|||.||::||.||:..||.||||||||||||
 Frog   356 VTDAKEASSIGFNPQHVHIYSASWGPNDDGKTVEGPGRLAQKAFEYGIKQGRNGKGSIFVWASGN 420

  Fly   561 GGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGS 625
            |||..|:|:|||||:||:|:|||||:|.|..|||.|:|||||||.|||| ...|:.:.:.|:...
 Frog   421 GGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATAYSSG-DYTDQRIISADLHNE 484

  Fly   626 LRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNGVK 690
                  ||..||||||||||||||.|||||.||:|||||||:|||:||...||....||..||..
 Frog   485 ------CTETHTGTSASAPLAAGIFALALEFNPDLTWRDMQHLVVWTSEYDPLANNAGWKKNGAG 543

  Fly   691 RKYSHKFGYGLMDAGAMVSLAE--QWTSVPPQHICKSRENNEDRKI---DGAYGSTLSTHMDVNG 750
            ...:.:||:||::|.|:|.||:  .|..|..:..|...:|....:.   ||    .::..:....
 Frog   544 LMVNSRFGFGLLNAKALVDLADPKTWKGVAEKKECIVEDNEFSPRFLRSDG----EVTIQIPTKA 604

  Fly   751 CAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHF 815
            |.|..|.::.|||:|...|:.:..||:|.|.||||:||.:.||.||.||.....|..|.|:|||.
 Frog   605 CEGQDNHIKSLEHLQLEATIEYTRRGDLHITLTSPLGTNTVLLTERERDTSPYGFKSWDFMSVHT 669

  Fly   816 WGEKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQPMRLKSELLNSSPQLRSPSSSNPFL 880
            |||...|.|||::.:...|:.|:..|:| |:||.:||||||..:|                :|.:
 Frog   670 WGEDPAGTWTLKISDVSGRKKNEGRIVS-WKLILHGTSTQPEHMK----------------HPRV 717

  Fly   881 FPSASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSD-PEPATATLDGQNVTAAIAGGSSAESL 944
            :.| .|:.|....|.....|     :..:.|..|..:: ||....|.|.|.      ....|:||
 Frog   718 YTS-YNVVQNDRRGAEKMDD-----IEKEPISESFTTERPEVTKNTPDSQE------AAERAKSL 770

  Fly   945 GFTASAAQLVAAPETRDG------DKKI 966
                :.|.|:.....|||      ||.|
 Frog   771 ----AIAHLLKNAFDRDGGSFPLEDKDI 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:465126	29/75 (39%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	375..674	CDD:173789	185/301 (61%)
		P_proprotein	761..849	CDD:460225	40/87 (46%)
		GF_recep_IV	970..1073	CDD:464344
		VSP	1020..1379	CDD:146106
		FU	1401..1444	CDD:214589
pcsk1	XP_004910515.3	S8_pro-domain	145..221	CDD:465126	29/75 (39%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	232..526	CDD:173789	184/300 (61%)
		P_proprotein	615..702	CDD:460225	40/87 (46%)
		Proho_convert	813..850	CDD:463483