DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur2 and LOC100330575

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	XP_002666956.3	Gene:	LOC100330575 / 100330575	-ID:	-	Length:	983	Species:	Danio rerio

Alignment Length:	738	Identity:	215/738 - (29%)
Similarity:	305/738 - (41%)	Gaps:	135/738 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   953 LVAAP--ETRDGDKKILHSCDAECDSSGCYGRGPTQCVAC-SHYRL--DNTCVSRCPPRSFPNQV 1012
            |::.|  :..||:.:....||..|  |.|:|.....|::| |.:.|  ::.||..||...:.|..
Zfish   282 LISCPPGQYLDGESRSCRYCDVSC--STCFGPAAQNCISCASGFMLEQESVCVDGCPLGFYGNSS 344

  Fly  1013 GI-CWPCHDTCETCAGAGPDSCLTCA--PAHLHVIDLAVCLQFCPDGYFENSRNRTCVPCEPNCA 1074
            .: |..|.:.||.|..|  |.||||.  ...|:::. ..|...||:|||| ::..||.||:..|.
Zfish   345 SLQCERCAENCELCQSA--DECLTCKSDSYQLYLLQ-GNCWSECPEGYFE-TKMGTCEPCDGLCL 405

  Fly  1075 SCQDHPEYCTSCDHHLVMHEHKCYSACPLDTYETED-------------------NKCAF----- 1115
            :|......|.||...|.:...:|..:|...:|..||                   .||:|
Zfish   406 TCDGTSTECLSCREGLHLANGQCRQSCAPMSYVAEDGTCRRCAPHCDACTDYSICTKCSFLYLLL 470

  Fly  1116 -----------------------CHSTCATCNGPTDQDCITCR-SSRYAWQNKCLISCPDGFYAD 1156
                                   ||:|||||:||...||.||. .:...::..||..||.|.|..
Zfish   471 NGACKAVCPKGYFEDLDQGVCVSCHATCATCSGPLSDDCETCSVLTPKLYEGTCLEMCPGGTYYQ 535

  Fly  1157 KKRLECMPCQEGCKTC--TSNGVCSECLQNWTLNKRD-KCIVSGSEGCSESEFYSQVEGQCRPCH 1218
            ....||..|.:.|..|  .....|.:|.:...|:... .|.|:|...|....|....:..|:.||
Zfish   536 TSDKECQECHQTCALCEGPEPTQCLQCGKGLVLDPNTMMCGVTGDSDCPPRTFLQNNQFTCQACH 600

  Fly  1219 ASCGSCNGPADTSCTSCPPNRLLEQSRCVSGCREGFF--------VEAGSLCSPCLHTCSQC--V 1273
            ..|.||.||....|.:|.....|....|||.|..|.:        ||.| .|.||.|.|..|  .
Zfish   601 RLCQSCEGPGPFDCQTCALPNFLNNGSCVSKCPAGTYSAHEVADGVELG-FCMPCDHVCGTCTGA 664

  Fly  1274 SRTNCSNCSKG-LELQNGECRTTCADGYYSDRGICAKCYLSCHTCSGPRRNQCVQC-PAGWQL-A 1335
            |..:|.:|:.| |.|.:..|...|..||||....|.||..||..||||..:.|..| |....| .
Zfish   665 SPRDCLSCAPGYLHLLSHLCVIHCPTGYYSSGERCEKCDSSCVQCSGPGPDACRVCTPTMLDLQG 729

  Fly  1336 AGECHPECPEGFYKSDFGCQKCHHYCKTCNDAGPLACTSCPPHSMLDGGLCM-ECLSSQYYDTTS 1399
            ..:|..:||:.|::|...|::||..||:|.|..|..|.||...|:|..|:|. .|..|:|| :..
Zfish   730 TRQCVDQCPQRFFESGHSCRQCHTSCKSCTDNTPQGCVSCDWGSVLQDGVCYPRCEESRYY-SQD 793

  Fly  1400 ATCKTCHDSCRSCFGPGQFSCKGCVPPLHLDQLNSQCVSCCQNQTLAEKTSSAACCNCDGETGEC 1464
            ..|:.|..||:.|...|..||..|.|...|..::|||:.|||::...:|     ||.||..:..|
Zfish   794 GVCEPCAGSCKHCSAAGPRSCLTCRPGFALHAIDSQCLPCCQSEQTEQK-----CCLCDSSSALC 853

  Fly  1465 KATSTGGKRRTVVGSGSAYKSSESKHGSFENDGNAREFVLRLDSPLTAITAIAVAICLLIITIFS 1529
            .....               .:||:.          :.:||..:...|..|:..|: ||.:.:..
Zfish   854 LEMPV---------------PNESQD----------DIILRSKAVQHASAALPAAL-LLAVVLAL 892

  Fly  1530 IIFAVLQRNSNHVSRNSVRYRKIANTSSG-RRKNLSAKPTSDARFIFNIGEDDDTDGDNSD---D 1590
            ::||::|..    ::..:.:|:.....|| .|:....:|..     ..:.|.||: ||..|   .
Zfish   893 VVFALVQAR----AKKRLCWRRSYERLSGVAREEPRPRPMP-----HGVPEPDDS-GDEVDVVYT 947

  Fly  1591 ELDGNVGTDINNRIVYDRKGNDH 1613
            ..||:         ||.|.|..|
Zfish   948 SRDGS---------VYRRYGFIH 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789
		Peptidase_S8	411..700	CDD:278510
		P_proprotein	761..849	CDD:279782
		Furin-like	966..1126	CDD:279142	59/212 (28%)
		FU	970..1013	CDD:238021	15/45 (33%)
		FU	1017..1067	CDD:238021	19/51 (37%)
		FU	1063..1106	CDD:214589	12/42 (29%)
		GF_recep_IV	1068..1232	CDD:291509	56/214 (26%)
		FU	1116..1163	CDD:238021	20/47 (43%)
		FU	1211..1255	CDD:214589	16/43 (37%)
		FU	1259..1301	CDD:214589	16/44 (36%)
		FU	1304..1348	CDD:214589	16/45 (36%)
		FU	1356..1403	CDD:238021	18/47 (38%)
		FU	1401..1444	CDD:214589	17/42 (40%)
LOC100330575	XP_002666956.3	GF_recep_IV	258..355	CDD:291509	21/74 (28%)
		FU	301..349	CDD:238021	15/49 (31%)
		Furin-like_2	<327..390	CDD:292535	21/65 (32%)
		FU	494..542	CDD:238021	20/47 (43%)
		FU	595..637	CDD:214589	16/41 (39%)
		GF_recep_IV	599..717	CDD:291509	45/118 (38%)
		FU	651..693	CDD:214589	15/41 (37%)
		FU	698..742	CDD:214589	16/43 (37%)
		FU	745..789	CDD:214589	17/43 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010