DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur2 and pcsk9

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	XP_003200725.1	Gene:	pcsk9 / 100150316	ZFINID:	ZDB-GENE-060927-1	Length:	667	Species:	Danio rerio

Alignment Length:	699	Identity:	132/699 - (18%)
Similarity:	229/699 - (32%)	Gaps:	200/699 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 QHHHVSKRSLRSSRKHQGALKSENEVKWMQQQHEKV---RRKRDGPYQDLPTYSPYNLLRQHGGY 340
            |.:..:|.:.|...::...:::...|..:::...::   ..||....:.|.|||  ...|   |:
Zfish    54 QFYRCTKDAWRMPGQYLVVMRNGTHVNQVERTTRRLSAKAAKRGYLIEILQTYS--GAFR---GF 113

  Fly   341 VVDPN----------PHLSFSPESISLASHS-----QR-MEYRDVSSHFIFPDPLFKEQWYLVSK 389
            :|..:          ||:.:..|..|:.:.|     || ::.:..:..:..|
Zfish   114 LVKMSSDVLHMAVKLPHVEYIEEDSSIFAQSIPWNLQRVLQNKHEAGKYSPP------------- 165

  Fly   390 NGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQNYDPEASFDINGNDSDPTPQDN 454
            |.|||.|                   |.:||..:|..|.::...        :...|.:..|:::
Zfish   166 NDGAKVG-------------------VYLLDTSVQLTHREVEDR--------VMVTDFNRVPEED 203

  Fly   455 G---------DNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGKVNDVVEAQALSLNPS 510
            |         .:.|||..||.::.      ...|||..||:..||:|:.:....|......|...
Zfish   204 GVRVHRQASQCDSHGTHIAGVISG------RDSGVARGASVNSVRVLNCQGKGTVSGALAGLEYI 262

  Fly   511 HIDIYSASWGPEDDGSTVDGPGPLARRAFIYGV-----TSGRQ--GKGSIFVWASGNGGRYTDSC 568
            ...:.|....|           .:....|:.|.     |:.|:  ..|::.:.|:||   |.|..
Zfish   263 QSSLASQPVSP-----------VILLLPFVGGFSRTLNTACRKIVESGAVLIAAAGN---YNDDA 313

  Fly   569 NCDGYTNSIFTLSISSATQA------GFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGSLR 627
            ......:....:::.:...|      |.....:..|....|       ||.|...|:.|..
Zfish   314 CLYSPASEPEVITVGAVNFADQPLNRGTTGTNVGRCVDVFA-------PGDDIISASSDCP---- 367

  Fly   628 PDHICTVEHTGTSASAPLAAGICALALEANP---------ELTWRDMQYLV-------------- 669
               .|....:|||.:|...||:.|:.|...|         :|.:..::.::
Zfish   368 ---TCFTTKSGTSQAAAHVAGVAAVLLNLRPNSSSAEVLQQLRYHSVKQVINPESLPVMHRLTTP 429

  Fly   670 -VYTSRPAPLEKENGWTLNG----VKRKYSHKFGYGLMDAGAMVSLA-EQWTSVPPQHICKSREN 728
             :..:.|.|..     ||.|    .:..:|.:      .|..:.|.| .:..|......|.|..:
Zfish   430 NMVVALPDPTS-----TLTGEDLLCRSVWSER------SASPVFSTAVSRCRSTEEMLSCSSFSD 483

  Fly   729 NEDR---KIDGAYGSTLSTHMDVNGCAGTINEVRYL--EHVQCRITLRFFPRGNLRILLTSPMGT 788
            |..|   :::...|......::|||..|.....|..  ...||:             :|..|...
Zfish   484 NGMRAGERVEERDGQKECVAVNVNGGPGVFAVARCCTGHRAQCQ-------------MLEGPERG 535

  Fly   789 TSTLLFERPRDIVKSNFDDWPFLSVHFWGEKAEGRWTLQVINGGRRR-VNQPGILSKWQLIFYG- 851
            ...   |.|.:   .:.....|.|..  ||.::...||   :|.||. ..:.|::|      |.
Zfish   536 AGA---ECPPE---HHLTGCSFSSSS--GEASDSDRTL---HGSRRTCAAKKGMMS------YAF 583

  Fly   852 ---TSTQPMRLKSELLNSSPQLRSPSSSNPFLFPSASNIGQPANEGGNF 897
               |||...|||...||:..|....|..:.:...:...:.:.|...|.|
Zfish   584 CCHTSTLECRLKEHHLNTLSQQVEVSCEDSWTLTACEALSRDAVIHGAF 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	4/41 (10%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	61/344 (18%)
		Peptidase_S8	411..700	CDD:278510	61/338 (18%)
		P_proprotein	761..849	CDD:279782	17/90 (19%)
		Furin-like	966..1126	CDD:279142
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
pcsk9	XP_003200725.1	Inhibitor_I9	68..138	CDD:283552	13/74 (18%)
		Peptidases_S8_PCSK9_ProteinaseK_like	147..412	CDD:173790	63/338 (19%)
		Peptidase_S8	167..406	CDD:278510	58/299 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576281
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740