DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur2 and pcsk1

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_001131134.1	Gene:	pcsk1 / 100005716	ZFINID:	ZDB-GENE-071009-1	Length:	755	Species:	Danio rerio

Alignment Length:	766	Identity:	320/766 - (41%)
Similarity:	428/766 - (55%)	Gaps:	118/766 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 YTNEFAVNIPAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSKRSLRSSRKHQGALKSENE 303
            |.||:||.||.|.|.|..||.:.|:....|||:|:|:|||:.|....|:.||:......|..::.
Zfish    29 YLNEWAVEIPGGVQNARSIADEFGYQLVRQIGALENHYLFKRHSHPSRTKRSADHITKRLSEDDR 93

  Fly   304 VKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQRMEYRD 368
            |.|.:||:||.|.||          :|..                               :|.:|
Zfish    94 VSWAEQQYEKRRAKR----------APLG-------------------------------VECKD 117

  Fly   369 VSSHFIFPDPLFKEQWYLV-SKNGGAKDGLDMNVGPAWQKGYTGKGVVVSILDDGIQTNHPDLAQ 432
            .|...:|.||::.:||||. ::...:...||::|.|.|:||.||||||:::||||::.||.|:..
Zfish   118 CSVDKLFDDPMWNQQWYLQDTRTSSSLPKLDLHVIPVWKKGITGKGVVITVLDDGLEWNHTDIYP 182

  Fly   433 NYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIGGVRMLDGK 495
            ||||.||:|.|.||.||.|:  ...:||||||||||:|..|.||.||||||||:.:||:|||||.
Zfish   183 NYDPAASYDFNDNDPDPFPRYDSTNENKHGTRCAGEIAMQADNNKCGVGVAYNSKVGGIRMLDGI 247

  Fly   496 VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKGSIFVWASGN 560
            |.|.:||.::..||.|:|||||||||.|||.||:|||.||::||.||:..||.||||||||||||
Zfish   248 VTDAIEASSIGYNPDHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGIQKGRGGKGSIFVWASGN 312

  Fly   561 GGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGHDKSVATVDMDGS 625
            |||..|:|:|||||:|::|:|||||:|.|..|||.|:|||||||.|||| ...|:.:.:.|:...
Zfish   313 GGRQGDNCDCDGYTDSLYTISISSASQQGLSPWYAEKCSSTLATAYSSG-DYTDQRITSADLHNE 376

  Fly   626 LRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEKENGWTLNGVK 690
                  ||..||||||||||||||.|||||.||:|||||:|:|||:||...||....||..||..
Zfish   377 ------CTETHTGTSASAPLAAGIFALALEQNPDLTWRDLQHLVVWTSEFDPLANNPGWKRNGAG 435

  Fly   691 RKYSHKFGYGLMDAGAMVSLAEQ--WTSVPPQHICKSR-ENNEDRKIDGAYGSTLSTHMDVNGCA 752
            ...:.:||:||::|.|:|.||:.  |..||.:..|..| |..:.|.:..|  ..:|..:....||
Zfish   436 LMVNSRFGFGLLNAKALVDLADPKVWKHVPEKKQCIVRDETFQPRPLKAA--GEISIEIPTKACA 498

  Fly   753 GTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPRDIVKSNFDDWPFLSVHFWG 817
            |..|.|..|||||..:::.:..||:|.|.||||.|||:.||.||.||...:.|.:|.|:|||.||
Zfish   499 GQANSVMSLEHVQVEVSIEYTRRGDLHITLTSPSGTTTVLLAERERDTSSNGFRNWAFMSVHTWG 563

  Fly   818 EKAEGRWTLQVINGGRRRVNQPGILSKWQLIFYGTSTQPMRLKS-----------------ELLN 865
            |...|.|.|::.:...|..|:..|:| |:||.:|||.:|..:|.                 |.:.
Zfish   564 ENPTGTWILKITDTSGRMENEGQIIS-WKLILHGTSEKPEHMKKARVYTPYNAVQNDRRGVEPME 627

  Fly   866 SSPQLRSPSSSNPFLFPSASNIGQPANEGGNFNTDSFASYLNYQNIFSSAGSDPEPATATLDGQN 930
            ...:..:|:   |.|.|...|...|                           |..|:||::....
Zfish   628 DMMKQEAPT---PALKPEIPNQAIP---------------------------DSPPSTASMSIPE 662

  Fly   931 VTAAIAGGSSAESLGF-----TASAAQLVAAP-----ETRDGDKKILHSCD 971
            |.:    |.|..:|..     :|...|:.|||     :.|...:|:..:.|
Zfish   663 VNS----GPSTANLALLRLLQSAFNRQMPAAPPKSFQQERIPPQKLYQALD 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	31/75 (41%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	182/301 (60%)
		Peptidase_S8	411..700	CDD:278510	176/290 (61%)
		P_proprotein	761..849	CDD:279782	40/87 (46%)
		Furin-like	966..1126	CDD:279142	1/6 (17%)
		FU	970..1013	CDD:238021	1/2 (50%)
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
pcsk1	NP_001131134.1	S8_pro-domain	32..108	CDD:293079	31/75 (41%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	124..418	CDD:173789	181/300 (60%)
		Peptidase_S8	161..435	CDD:278510	174/280 (62%)
		P_proprotein	507..594	CDD:279782	40/87 (46%)
		Proho_convert	716..752	CDD:288988
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720