DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur2 and pcsk2

DIOPT Version :9

Sequence 1:	NP_727963.1	Gene:	Fur2 / 32604	FlyBaseID:	FBgn0004598	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_001135738.1	Gene:	pcsk2 / 100004460	ZFINID:	ZDB-GENE-090608-1	Length:	646	Species:	Danio rerio

Alignment Length:	634	Identity:	283/634 - (44%)
Similarity:	373/634 - (58%)	Gaps:	70/634 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 EEAIYTNEFAVNI-PAGKQMADVIATKHGFINRGQIGSLDNYYLFQHHHVSK-RSLRSSRKHQGA 297
            :|...|..|.|.: .|..:.|..:|.:|||.:..::...::.:.|....:.| |..||..:....
Zfish    30 DELFITGHFLVQMREAAPEDAQKLALEHGFESARKLPFGEDLFHFYPLEMPKTRRKRSLHQQHHR 94

  Fly   298 LKSENEVKWMQQQHEKVRRKRDGPYQDLPTYSPYNLLRQHGGYVVDPNPHLSFSPESISLASHSQ 362
            |.|::.||.:..|....|:||.  |:||                  ||..::.|
Zfish    95 LASDHRVKNVFPQEGFGRQKRG--YRDL------------------PNTDVNMS----------- 128

  Fly   363 RMEYRDVSSHFIFPDPLFKEQWYLVSKNGGAKD---GLDMNVGPAWQKGYTGKGVVVSILDDGIQ 424
                          ||||.:||||:  |.|..|   |||:||..||..|:|||||.::|:||||.
Zfish   129 --------------DPLFTKQWYLI--NTGQADGTPGLDLNVAEAWSLGFTGKGVTIAIMDDGID 177

  Fly   425 TNHPDLAQNYDPEASFDINGNDSDPTPQ--DNGDNKHGTRCAGEVAAVAFNNFCGVGVAYNASIG 487
            ..|||||.||:.|||||.:.||..|.|:  |:..|.|||||||||:||:.||.||||||||:.:.
Zfish   178 YLHPDLASNYNAEASFDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAVSNNNICGVGVAYNSKVA 242

  Fly   488 GVRMLDGK-VNDVVEAQALSLNPSHIDIYSASWGPEDDGSTVDGPGPLARRAFIYGVTSGRQGKG 551
            |:||||.. :.|::||.::|..|..||||||||||.|||.|||||..|..:|...||..||.|||
Zfish   243 GIRMLDQPFMTDIIEASSISHMPQVIDIYSASWGPTDDGKTVDGPRELTLQAMADGVNKGRGGKG 307

  Fly   552 SIFVWASGNGGRYTDSCNCDGYTNSIFTLSISSATQAGFKPWYLEECSSTLATTYSSGTPGH-DK 615
            ||:|||||:||.| |.||||||.:|::|:||:||...|....|.|.||||||:|:|:|...: :.
Zfish   308 SIYVWASGDGGSY-DDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEA 371

  Fly   616 SVATVDMDGSLRPDHICTVEHTGTSASAPLAAGICALALEANPELTWRDMQYLVVYTSRPAPLEK 680
            .|||.|:.|:      ||:.|:||||:||.|||:.||||||||.|||||:|:|.|.||:...|..
Zfish   372 GVATTDLYGN------CTLRHSGTSAAAPEAAGVFALALEANPNLTWRDLQHLTVLTSKRNKLHD 430

  Fly   681 E-NGWTLNGVKRKYSHKFGYGLMDAGAMVSLAEQWTSVPPQHICKSRENNEDRKIDGAYGSTLST 744
            | :.|..|||..:::|.||||::|||.||.||..|.:||.:..|.:....:..||..  |:.|..
Zfish   431 EVHQWRRNGVGLEFNHLFGYGVLDAGGMVKLARDWKTVPERFHCVAGSMQDIHKIQS--GNKLLL 493

  Fly   745 HMDVNGCAGTINEVRYLEHVQCRITLRFFPRGNLRILLTSPMGTTSTLLFERPR-DIVKSNFDDW 808
            .:..:.|.|..|.||||||||..||:....||:|.|.:||||||.|.||..||| |..|..||.|
Zfish   494 SISTDACQGKDNFVRYLEHVQAVITVNASRRGDLNINMTSPMGTKSILLSRRPRDDDAKVGFDKW 558

  Fly   809 PFLSVHFWGEKAEGRWTLQVINGGRRRVN-QPGILSKWQLIFYGTSTQP 856
            ||::.|.|||...|.|.|:|  |.:.:.: |.|:|.:|.|:.:||.:.|
Zfish   559 PFMTTHTWGEDPRGPWLLEV--GFQSQSDMQSGLLKEWTLMLHGTQSAP 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur2	NP_727963.1	S8_pro-domain	242..318	CDD:293079	19/77 (25%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	375..674	CDD:173789	174/305 (57%)
		Peptidase_S8	411..700	CDD:278510	164/293 (56%)
		P_proprotein	761..849	CDD:279782	44/89 (49%)
		Furin-like	966..1126	CDD:279142
		FU	970..1013	CDD:238021
		FU	1017..1067	CDD:238021
		FU	1063..1106	CDD:214589
		GF_recep_IV	1068..1232	CDD:291509
		FU	1116..1163	CDD:238021
		FU	1211..1255	CDD:214589
		FU	1259..1301	CDD:214589
		FU	1304..1348	CDD:214589
		FU	1356..1403	CDD:238021
		FU	1401..1444	CDD:214589
pcsk2	NP_001135738.1	S8_pro-domain	37..115	CDD:293079	19/77 (25%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	128..424	CDD:173789	175/329 (53%)
		Peptidase_S8	164..441	CDD:278510	160/283 (57%)
		P_proprotein	510..598	CDD:279782	44/89 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920