DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nonA and PSPC1

DIOPT Version :9

Sequence 1:	NP_727962.1	Gene:	nonA / 32603	FlyBaseID:	FBgn0004227	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001035879.1	Gene:	PSPC1 / 55269	HGNCID:	20320	Length:	523	Species:	Homo sapiens

Alignment Length:	410	Identity:	164/410 - (40%)
Similarity:	238/410 - (58%)	Gaps:	24/410 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 GPTFELEPVEVPTETKFSGRNRLYVGNLTNDITDDELREMFKPYGEISEIFSNLDKNFTFLKVDY 346
            |.|.:::....|.|..::.|.||:||||..|||:::.:.:|:.|||.||:|.|.|:.|.|::::.
Human    62 GFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLES 126

  Fly   347 HPNAEKAKRALDGSMRKGRQLRVRFAPNATILRVSNLTPFVSNELLYKSFEIFGPIERASITVDD 411
            ...||.||..|||::.|.|.||:|||.:...|.|.||:|.||||||.::|..|||:|:|.:.|||
Human   127 RTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDD 191

  Fly   412 RGKHMGEGIVEFAKKSSASACLRMCNEKCFFLTASLRPCLVDPMEVNDDTDGLPEKAFNKKMPDF 476
            ||:..|:|.||||.|..|...|..|.:..|.||.:.||.:|:|||..||.||||||.. :|...:
Human   192 RGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLM-QKTQQY 255

  Fly   477 NQERSIGPRFADPNSFEHEYGSRWKQLHNLFKTKQDALKRELKMEEDKLEAQMEYARYEQETELL 541
            ::||...||||.|.:||.||.||||.|..:.|.:::.:.|.::..::||||:||.||:|.:..|:
Human   256 HKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLM 320

  Fly   542 RQELRKREVDNERKKLEWEMREKQAEEMRK---REEETMRRHQTEMQSHMNRQEEDMLRRQQETL 603
            ||:|.:|:  .|.::|| |:|.::.::.::   |.||..||.:.||..|   :|::.||||||.
Human   321 RQDLMRRQ--EELRRLE-ELRNQELQKRKQIQLRHEEEHRRREEEMIRH---REQEELRRQQEG- 378

  Fly   604 FMKAQQLNSLLDQQEGFGGGGGGNNSTFDNF----AGNSNSPFEVFRGNNNNNSTMIGNNAAPNT 664
            |......|...:.:.|..|..|..|.. |.|    |||...| .:...|.||.:|:.|....|..
Human   379 FKPNYMENREQEMRMGDMGPRGAINMG-DAFSPAPAGNQGPP-PMMGMNMNNRATIPGPPMGPGP 441

  Fly   665 QEIKRLDGPINEITSNFSPP 684
            ..     ||  |..:|...|
Human   442 AM-----GP--EGAANMGTP 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA	NP_727962.1	RRM1_p54nrb_like	301..371	CDD:240778	32/69 (46%)
		RRM2_p54nrb_like	377..456	CDD:240779	39/78 (50%)
		NOPS_NONA_like	447..546	CDD:240580	45/98 (46%)
		GBP_C	<508..613	CDD:303769	38/107 (36%)
		coiled coil	584..595	CDD:293879	3/10 (30%)
		coiled coil	603..613	CDD:293879	2/9 (22%)
PSPC1	NP_001035879.1	RRM1_PSP1	81..151	CDD:241030	32/69 (46%)
		Sufficient for paraspeckles localization	125..358		104/236 (44%)
		RRM2_PSP1	157..236	CDD:241033	39/78 (50%)
		NOPS_PSPC1	227..320	CDD:240584	42/93 (45%)
		Sufficient for perinucleolar caps localization and interaction with NONO. /evidence=ECO:0000269\|PubMed:16148043	231..358		53/130 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9124
eggNOG	1	0.900	-	-		E1_KOG0115
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2670
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1274880at2759
OrthoFinder	1	1.000	-	-		FOG0001632
OrthoInspector	1	1.000	-	-		mtm8550
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4077
SonicParanoid	1	1.000	-	-		X1036
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.960