DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nonA and RAVER2

DIOPT Version :9

Sequence 1:	NP_727962.1	Gene:	nonA / 32603	FlyBaseID:	FBgn0004227	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001353094.1	Gene:	RAVER2 / 55225	HGNCID:	25577	Length:	691	Species:	Homo sapiens

Alignment Length:	211	Identity:	54/211 - (25%)
Similarity:	89/211 - (42%)	Gaps:	42/211 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 GGGAGGAMNSTNMGGGGGGGGGGGPRGGEDFFITQRLRSISGPTFE------------LEPVEVP 293
            |||.|||    .:|...|.|.|.|.||             .||:.|            |.|.||.
Human     8 GGGEGGA----GLGSAAGLGPGPGLRG-------------QGPSAEAHEGAPDPMPAALHPEEVA 55

  Fly   294 T-----ETKFSGRNRLYVGNLTNDITDDELREMFKPYGEISEIFSNLDKNFTFLKVDYHPNAEKA 353
            .     :.:.|.|.::.|.||..|....|:.::.|.| ::...:.:.:|...|:.:   .|.|:|
Human    56 ARLQRMQRELSNRRKILVKNLPQDSNCQEVHDLLKDY-DLKYCYVDRNKRTAFVTL---LNGEQA 116

  Fly   354 KRALDGSMR---KGRQLRVRFAPNATILRVSNLTPFVSNELLYKSFEIFGPIERASITVDD-RGK 414
            :.|:....:   :|:.|.|:..|...:|.::|:....::|...:....:|.|||..:...: .|.
Human   117 QNAIQMFHQYSFRGKDLIVQLQPTDALLCITNVPISFTSEEFEELVRAYGNIERCFLVYSEVTGH 181

  Fly   415 HMGEGIVEFAKKSSAS 430
            ..|.|.||:.||..|:
Human   182 SKGYGFVEYMKKDFAA 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA	NP_727962.1	RRM1_p54nrb_like	301..371	CDD:240778	17/72 (24%)
		RRM2_p54nrb_like	377..456	CDD:240779	15/55 (27%)
		NOPS_NONA_like	447..546	CDD:240580
		GBP_C	<508..613	CDD:303769
		coiled coil	584..595	CDD:293879
		coiled coil	603..613	CDD:293879
RAVER2	NP_001353094.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		16/55 (29%)
		RRM1_RAVER2	70..139	CDD:241108	16/72 (22%)
		RRM2_RAVER2	143..219	CDD:241110	15/55 (27%)
		RRM3_RAVER2	229..326	CDD:241112
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..522
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..574
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154202
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840