DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nonA and Nono

DIOPT Version :9

Sequence 1:	NP_727962.1	Gene:	nonA / 32603	FlyBaseID:	FBgn0004227	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	XP_030107241.1	Gene:	Nono / 53610	MGIID:	1855692	Length:	482	Species:	Mus musculus

Alignment Length:	420	Identity:	161/420 - (38%)
Similarity:	226/420 - (53%)	Gaps:	60/420 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 QQRDNRNRSGPRPGGGAGGAMNSTNMGGGGGGGGGGGPRGGEDFFITQRLRSISGPTFELEPVEV 292
            ||:..:.:..|.|....|...:|.|                            .|.|.:|:....
Mouse    30 QQQQQQQQQPPPPIPANGQQASSQN----------------------------EGLTIDLKNFRK 66

  Fly   293 PTETKFSGRNRLYVGNLTNDITDDELREMFKPYGEISEIFSNLDKNFTFLKVDYHPNAEKAKRAL 357
            |.|..|:.|:||:||||..|||::|:|::|:.||:..|:|.:.||.|.|::::....||.||..|
Mouse    67 PGEKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIAKVEL 131

  Fly   358 DGSMRKGRQLRVRFAPNATILRVSNLTPFVSNELLYKSFEIFGPIERASITVDDRGKHMGEGIVE 422
            |....:|:|||||||.::..|.|.||..:||||||.::|.:||.:|||.:.|||||:..|:||||
Mouse   132 DNMPLRGKQLRVRFACHSASLTVRNLPQYVSNELLEEAFSVFGQVERAVVIVDDRGRPSGKGIVE 196

  Fly   423 FAKKSSASACLRMCNEKCFFLTASLRPCLVDPMEVNDDTDGLPEKAFNKKMPDFNQERSIGPRFA 487
            |:.|.:|...|..|:|..|.||...||..|:||:..||.:|||||...|.. .|::||...||||
Mouse   197 FSGKPAARKALDRCSEGSFLLTTFPRPVTVEPMDQLDDEEGLPEKLVIKNQ-QFHKEREQPPRFA 260

  Fly   488 DPNSFEHEYGSRWKQLHNLFKTKQDALKRELKMEEDKLEAQMEYARYEQETELLRQELRKR---- 548
            .|.|||:||..|||.|..:.|.:||.:.|.:|...:|||.:||.||:|.:..|:||:|.:|
Mouse   261 QPGSFEYEYAMRWKALIEMEKQQQDQVDRNIKEAREKLEMEMEAARHEHQVMLMRQDLMRRQEEL 325

  Fly   549 ----EVDNERKKLEWEMREKQAEEMRKREEETMRRHQTEMQSHMNRQEEDMLRRQQETL---FMK 606
                |:.|:..:...::..:|.||.|:||||            |.||:|:|:|||||..   |..
Mouse   326 RRMEELHNQEVQKRKQLELRQEEERRRREEE------------MRRQQEEMMRRQQEGFKGTFPD 378

  Fly   607 AQQLNSLLDQQE--------GFGGGGGGNN 628
            |..|....|.:|        ..||..|.||
Mouse   379 AVYLPCAYDVREQEIRMGQMAMGGAMGINN 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA	NP_727962.1	RRM1_p54nrb_like	301..371	CDD:240778	32/69 (46%)
		RRM2_p54nrb_like	377..456	CDD:240779	39/78 (50%)
		NOPS_NONA_like	447..546	CDD:240580	46/98 (47%)
		GBP_C	<508..613	CDD:303769	41/115 (36%)
		coiled coil	584..595	CDD:293879	4/10 (40%)
		coiled coil	603..613	CDD:293879	3/12 (25%)
Nono	XP_030107241.1	RRM1_p54nrb	75..145	CDD:241032	32/69 (46%)
		RRM_SF	151..230	CDD:388407	39/78 (50%)
		NOPS_p54nrb_PSF_PSPC1	221..313	CDD:240581	43/92 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844440
Domainoid	1	1.000	74	1.000	Domainoid score	I9084
eggNOG	1	0.900	-	-		E1_KOG0115
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2790
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1274880at2759
OrthoFinder	1	1.000	-	-		FOG0001632
OrthoInspector	1	1.000	-	-		mtm8779
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4077
SonicParanoid	1	1.000	-	-		X1036
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.890