DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonA and spen

DIOPT Version :9

Sequence 1:	NP_727962.1	Gene:	nonA / 32603	FlyBaseID:	FBgn0004227	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_722615.1	Gene:	spen / 44205	FlyBaseID:	FBgn0016977	Length:	5560	Species:	Drosophila melanogaster

Alignment Length:	817	Identity:	159/817 - (19%)
Similarity:	271/817 - (33%)	Gaps:	229/817 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 QRQQRGNQQANKNLGKHNAQKQNDSADGGPAEKKQRFGGPNAQNQNQNQNQNGGVTGGGGAVGGP 81
            |.||..:||.::.|  |.:...|......||.       |.:.:.|.:.:...|...|    |.|
  Fly  1397 QNQQNNHQQQSQQL--HGSSSSNTCLMASPAR-------PRSLSSNSSDSDVPGQNAG----GSP 1448

  Fly    82 NQN---KNFGNNKGGFVGNRNRNNNRAGNQNRTFPG------NNNPNQKPNNETSKADGPNALAK 137
            :.:   :||..|...:.|..:|.:......:...|.      .|......:::||.|.|.:..:.
  Fly  1449 SLDERLRNFEENYERWSGGSSREHISGHTPSSATPSWQLSMHMNLSTGLNSHQTSSASGNSNSSS 1513

  Fly   138 NNEPATAAAGQNQ-----------------ANQNANKGQNQRQGQNQ-------------NQNQV 172
            ....::|:..:::                 |.::......||..:||             :.|.|
  Fly  1514 GTVSSSASNSRHKFLDIDELQPSDIVKSVLAKKSVFDDDFQRLNKNQWYDPSSSDFALGSSSNIV 1578

  Fly   173 HGQG-------NQGGP--GNQGGA-------------GN-QGGQGNQGGAGNQGNGQGFRGRNAG 214
            .|..       :.|||  ||...|             || .||.||..|:.:.|..|.....:..
  Fly  1579 TGSSLVANVSRHPGGPCSGNTSPALPNLAATKATPIIGNCSGGLGNSTGSKSAGLLQRLSSLSPM 1643

  Fly   215 NNQGGGFSGGPQNQQRDNRNRSGPRPGGGAGG-----------AMNSTNMGGGGGG--------G 260
            |:.....|  |.|         .|.|....||           |...|...|..||        .
  Fly  1644 NSPQASMS--PYN---------SPSPSPSVGGVTACLGQLTKPAAPGTASAGLSGGTAASSSSPA 1697

  Fly   261 GGGGPRGGEDFFITQR--LRSISGPTFELEPV-----EVPTETKFSGRNRLYVGNLTNDITDDEL 318
            ...||..|..:.....  |.:.:.|...::|.     |:..:::.:|::.   ||
  Fly  1698 ANSGPTKGLQYPFPSHPPLPNTAAPPPAVQPAPPPLPEMGKQSRLTGQSS---GN---------- 1749

  Fly   319 REMFKPYGEISEIFSNLDKNFTFLKVDYHPNAEKAK------RALDGSMRKGRQLRVRFAPNA-- 375
                           ||.|:   |.|...|.:..|:      .::.||...|       ||::
  Fly  1750 ---------------NLTKS---LSVPDGPQSSPARVQLQKSASVPGSTNVG-------APSSLS 1789

  Fly   376 ---------TILRVSNLTPFVSNELLYKSFEIFGPIERASITVDDRGKHMGEGIVEFAKKSS--- 428
                     |...:|:.|...::.|...:..:..| ::::...::..|..|....:.:..||
  Fly  1790 LDSTTASVETSASISSSTSNGNSSLTSAAIHVQKP-QQSTFVEEEHTKKSGTSTSQSSSSSSKKI 1853

  Fly   429 ---------------------------ASACLRMCNEKCFFLTASLRPCLVDPMEVNDDTDGLPE 466
                                       ||:..:..|......:.|..|.:.|.....|||....|
  Fly  1854 SSTHDKLHSKHNNRSESDKKIKKSDKNASSSDKRKNSSTSQSSKSATPRIEDDSSEADDTADKAE 1918

  Fly   467 K--AFNKKMPDFNQERSIGPRFADPNSFEHEYGSRWKQLHNLFKTKQDALKRELKMEEDKLEAQM 529
            |  ...|:..:..::|....|    ...|.|...|..|.....|..:.|.:.|.:.|.:| :||.
  Fly  1919 KNQRHEKEKKERQEKREKDLR----KQVEREEKDRKAQQEEREKEDRKAKEEEKEREREK-KAQE 1978

  Fly   530 EYARYEQETELLRQELRKREVDNERKKLEWEMREKQAEEMRKREEETMRRHQTEMQSHMNRQEED 594
            :..:.|:|...||::.::.:...|::..|.::|||:..|...||:|...:...|.:.....|.|.
  Fly  1979 DREKKEREERELREKEQRDKEQKEKEIREKDLREKEQRERDNREKELRDKDLREKEMREKEQREK 2043

  Fly   595 MLRR---QQETLFMKAQQLNSLLD-QQEGFGGG----GGGNNSTFDNFAGNSNSPFEVFRGNNNN 651
            .|.|   |:|....:.:|....:| :|||.||.    .....|..| .||.::|...:...:|..
  Fly  2044 ELHREKDQREREHREKEQSRRAMDVEQEGRGGRMRELSSYQKSKMD-IAGEASSLTAIDCQHNKE 2107

  Fly   652 N--------------STMIGNNAAPNTQEIKRLDGPI 674
            |              ||...|.....::::.| :.|:
  Fly  2108 NAMDTIAQGTPGASPSTPSDNTPKERSRKLSR-NSPV 2143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA	NP_727962.1	RRM1_p54nrb_like	301..371	CDD:240778	12/75 (16%)
		RRM2_p54nrb_like	377..456	CDD:240779	14/108 (13%)
		NOPS_NONA_like	447..546	CDD:240580	25/100 (25%)
		GBP_C	<508..613	CDD:303769	28/107 (26%)
		coiled coil	584..595	CDD:293879	2/10 (20%)
		coiled coil	603..613	CDD:293879	1/9 (11%)
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795
		RRM3_SHARP	654..726	CDD:240796
		RRM4_SHARP	727..803	CDD:240797
		RILP-like	1997..>2055	CDD:304877	16/57 (28%)
		SPOC	5404..5527	CDD:285043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45459923
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23189
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030