DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonA and sfpq

DIOPT Version :9

Sequence 1:	NP_727962.1	Gene:	nonA / 32603	FlyBaseID:	FBgn0004227	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_998443.1	Gene:	sfpq / 406564	ZFINID:	ZDB-GENE-040426-2452	Length:	619	Species:	Danio rerio

Alignment Length:	658	Identity:	210/658 - (31%)
Similarity:	303/658 - (46%)	Gaps:	156/658 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 GGPNAQNQNQNQNQNGGVTGGGGAVGGPNQNKNFGNNKGGFVGNRNRNNNRAGNQNRTFPGNNNP 118
            |.||.:||||:..||.|...|||          |..|:|      |:.|..:..|....|..|
Zfish    26 GNPNFRNQNQHHFQNRGPQMGGG----------FRQNQG------NQGNQVSTQQKPQEPAQN-- 72

  Fly   119 NQKPNNETSKADGPNALAKNNEPATAAAGQNQANQNANKGQNQRQGQNQNQNQVHGQGN------ 177
              ||..:|..|.||                .||.|.||||...:|.......::.....
Zfish    73 --KPVVQTPPAQGP----------------GQAQQAANKGPTPQQTPTVAPPKIQSAPPKIQSPP 119

  Fly   178 ---QGGPGNQGGAGNQGGQGNQGGAGNQGNGQGFRGRNAGNNQGGGFSGGPQNQQRDNRNRSGPR 239
               |..|..|                              ||........||||||.|.    |:
Zfish   120 PKIQSPPPAQ------------------------------NNAKTPEIASPQNQQRKNL----PK 150

  Fly   240 PGGGAGGAMNSTNMGGGGGGGGGGGPRGGEDFFIT-------------QRLRSISGPTFE--LEP 289
            |      ||        |.|.....|...|.   |             |:.:....|..|  .:|
Zfish   151 P------AM--------GNGQKPPAPLKQEQ---TPAPTPPPAQQQQQQQQQQKQTPANEQSSQP 198

  Fly   290 VEV---------PTETKFSGRNRLYVGNLTNDITDDELREMFKPYGEISEIFSNLDKNFTFLKVD 345
            .|:         |.|..::.|.||::|||.||||:.|.|::|..|||.||||.|..|.|.|::::
Zfish   199 QELKATLSLLRKPGEKTYTQRCRLFIGNLPNDITEPEFRKLFAKYGEPSEIFINQGKGFGFIRLE 263

  Fly   346 YHPNAEKAKRALDGSMRKGRQLRVRFAPNATILRVSNLTPFVSNELLYKSFEIFGPIERASITVD 410
            ....||.||..||.:..|||.||||||.::..|.|.||:||||||||.::|..||.:|||.:.||
Zfish   264 SRALAEVAKAELDDTPMKGRPLRVRFATHSAALSVRNLSPFVSNELLEEAFSQFGLVERAIVIVD 328

  Fly   411 DRGKHMGEGIVEFAKKSSASACLRMCNEKCFFLTASLRPCLVDPMEVNDDTDGLPEKAFNKKMPD 475
            |||:..|:|||||:.|.:|...:...::..|.||:|.||.:|:.:|..||.|||||| ..:|.|.
Zfish   329 DRGRSTGKGIVEFSSKPAARKAMDRISDGVFLLTSSPRPIVVELLEQYDDEDGLPEK-LAQKNPS 392

  Fly   476 FNQERSIGPRFADPNSFEHEYGSRWKQLHNLFKTKQDALKRELKMEEDKLEAQMEYARYEQETEL 540
            :.:||...||||.|.:||:||..|||.|..:.|.::..:::.:....:|||.:|:.|.:|.:..:
Zfish   393 YQKEREQPPRFARPGTFEYEYSQRWKSLDEMEKQQRQQVEKNICEAREKLETEMDDAYHEHQANM 457

  Fly   541 LRQELRKR--------EVDNERKKLEWEMREKQAEEMRKREEETMRRHQTEMQSHMNRQEEDMLR 597
            |||:|.:|        |:.::..:...||:.:|.||.|:||||.||:          |:.|:.||
Zfish   458 LRQDLLRRQEELRRMEELHSQEMQKRKEMQLRQEEERRRREEEMMRQ----------REIEEQLR 512

  Fly   598 RQQETLFMKAQQLNSLLDQQE-----GFGGGGGGNNSTFDNFAGNSNSPFEV----FRGNNNNNS 653
            |::|    ::.::|:.:|.::     ...||.|.::.:|    |:.|..|.:    |.|:...:.
Zfish   513 RKRE----ESYRMNNFMDNRDREMRMNTSGGMGLSDMSF----GSPNQKFSLTGMSFDGHQGLSG 569

  Fly   654 TMIGNNAA 661
            :..|..|:
Zfish   570 STQGGLAS 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA	NP_727962.1	RRM1_p54nrb_like	301..371	CDD:240778	36/69 (52%)
		RRM2_p54nrb_like	377..456	CDD:240779	38/78 (49%)
		NOPS_NONA_like	447..546	CDD:240580	39/98 (40%)
		GBP_C	<508..613	CDD:303769	32/112 (29%)
		coiled coil	584..595	CDD:293879	2/10 (20%)
		coiled coil	603..613	CDD:293879	1/9 (11%)
sfpq	NP_998443.1	RRM1_PSF	219..289	CDD:241031	36/69 (52%)
		RRM2_p54nrb_like	295..374	CDD:240779	38/78 (49%)
		eNOPS_SF	365..461	CDD:297912	38/96 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589407
Domainoid	1	1.000	77	1.000	Domainoid score	I8758
eggNOG	1	0.900	-	-		E1_KOG0115
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3072
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1274880at2759
OrthoFinder	1	1.000	-	-		FOG0001632
OrthoInspector	1	1.000	-	-		mtm6571
orthoMCL	1	0.900	-	-		OOG6_107408
Panther	1	1.100	-	-	O	PTHR23189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4077
SonicParanoid	1	1.000	-	-		X1036
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790