DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonA and nono

DIOPT Version :9

Sequence 1:	NP_727962.1	Gene:	nonA / 32603	FlyBaseID:	FBgn0004227	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_963873.1	Gene:	nono / 321994	ZFINID:	ZDB-GENE-030131-713	Length:	441	Species:	Danio rerio

Alignment Length:	491	Identity:	168/491 - (34%)
Similarity:	250/491 - (50%)	Gaps:	85/491 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 QGNQGGAGNQGNGQGFRGRNAGNNQGGGFSGGPQNQQRDNRNRSGPRPGGGAGGAMNSTNMGGGG 257
            |||:|....|.|                  .|||.||.:.:.....:|.|......::
Zfish     2 QGNRGPRSEQQN------------------HGPQRQQPNPQQEQQRKPTGADSNGQHT------- 41

  Fly   258 GGGGGGGPRGGEDFFITQRLRSISGPTFELEPVEVPTETKFSGRNRLYVGNLTNDITDDELREMF 322
            ..|....|.              :|.|.:|:..:.|.|..::.|:||:||||....|::::.::|
Zfish    42 DAGEQSSPN--------------AGFTIDLQNFKKPGEKTYTQRSRLFVGNLPAGTTEEDVEKLF 92

  Fly   323 KPYGEISEIFSNLDKNFTFLKVDYHPNAEKAKRALDGSMRKGRQLRVRFAPNATILRVSNLTPFV 387
            ..||:.||||.|.|:.|.|::::....|:.||..||.::.:|||:|||||.:...|.|.||..||
Zfish    93 SKYGKASEIFINKDRGFGFIRLETKTLADIAKAELDDTIFRGRQIRVRFATHGAALTVKNLPQFV 157

  Fly   388 SNELLYKSFEIFGPIERASITVDDRGKHMGEGIVEFAKKSSASACLRMCNEKCFFLTASLRPCLV 452
            |||||.::|.:|||||||.:.|||||:..|:||||||.|.||...|..|.:..|.|||..||..:
Zfish   158 SNELLEEAFSMFGPIERAIVIVDDRGRPTGKGIVEFANKPSARKALDRCGDGAFLLTAFPRPVTI 222

  Fly   453 DPMEVNDDTDGLPEKAFNKKMPDFNQERSIGPRFADPNSFEHEYGSRWKQLHNLFKTKQDALKRE 517
            :|||..|:.:||||:..||. |.:::||...||||.|.|||:||..|||.|..:.|.:.:.:.|.
Zfish   223 EPMEQLDEEEGLPERLINKN-PVYHKEREQPPRFAQPGSFEYEYAMRWKALMEMEKQQYEQVDRN 286

  Fly   518 LKMEEDKLEAQMEYARYEQETELLRQELRKREVDNERKKLEWEMREKQAEEMRKREEETMRRHQT 582
            :|..::|||.::|.||:|.:..|:||:|.:|:.:..|.:.......::.::|..|:||..||.:.
Zfish   287 IKEAKEKLETELEAARHEHQVMLMRQDLLRRQEELRRMEEAHSQEVQKRKQMELRQEEERRRREE 351

  Fly   583 EMQSHMNRQEEDMLRRQQETLFMKAQQLNSLLDQQEGFGGGGGGNNSTFDNFAGNSNSPFEVFRG 647
            |:::|    .|:::||||                      |.||      ||:...:....:..|
Zfish   352 ELRAH----SEELMRRQQ----------------------GQGG------NFSEKRDPDMRMHMG 384

  Fly   648 NNN---NNSTMIGNNAAPNTQEIKRLDGPINEITSN 680
            ...   |.:.|.||  |.||       |..| :|||
Zfish   385 GQGMGMNRNPMGGN--ASNT-------GSTN-LTSN 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA	NP_727962.1	RRM1_p54nrb_like	301..371	CDD:240778	29/69 (42%)
		RRM2_p54nrb_like	377..456	CDD:240779	43/78 (55%)
		NOPS_NONA_like	447..546	CDD:240580	42/98 (43%)
		GBP_C	<508..613	CDD:303769	29/104 (28%)
		coiled coil	584..595	CDD:293879	2/10 (20%)
		coiled coil	603..613	CDD:293879	0/9 (0%)
nono	NP_963873.1	RRM_SF	71..141	CDD:302621	29/69 (42%)
		RRM2_p54nrb	147..226	CDD:241035	43/78 (55%)
		NOPS_p54nrb	217..310	CDD:240582	39/93 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589401
Domainoid	1	1.000	77	1.000	Domainoid score	I8758
eggNOG	1	0.900	-	-		E1_KOG0115
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3072
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1274880at2759
OrthoFinder	1	1.000	-	-		FOG0001632
OrthoInspector	1	1.000	-	-		mtm6571
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4077
SonicParanoid	1	1.000	-	-		X1036
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.890