DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonA and Nono

DIOPT Version :9

Sequence 1:	NP_727962.1	Gene:	nonA / 32603	FlyBaseID:	FBgn0004227	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001012356.1	Gene:	Nono / 317259	RGDID:	1549738	Length:	476	Species:	Rattus norvegicus

Alignment Length:	414	Identity:	160/414 - (38%)
Similarity:	227/414 - (54%)	Gaps:	53/414 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 QNQQRDNRNRSGPRPGGGAGGAMNSTNMGGGGGGGGGGGPRGGEDFFITQRLRSISGPTFELEPV 290
            |.||:..:.:..|.|....|...:|.|                            .|.|.:|:..
  Rat    31 QQQQQQQQQQQPPPPIPANGQQASSQN----------------------------EGLTIDLKNF 67

  Fly   291 EVPTETKFSGRNRLYVGNLTNDITDDELREMFKPYGEISEIFSNLDKNFTFLKVDYHPNAEKAKR 355
            ..|.|..|:.|:||:||||..|||::|:|::|:.||:..|:|.:.||.|.|::::....||.||.
  Rat    68 RKPGEKTFTQRSRLFVGNLPPDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIAKV 132

  Fly   356 ALDGSMRKGRQLRVRFAPNATILRVSNLTPFVSNELLYKSFEIFGPIERASITVDDRGKHMGEGI 420
            .||....:|:|||||||.::..|.|.||..:||||||.::|.:||.:|||.:.|||||:..|:||
  Rat   133 ELDNMPLRGKQLRVRFACHSASLTVRNLPQYVSNELLEEAFSVFGQVERAVVIVDDRGRPSGKGI 197

  Fly   421 VEFAKKSSASACLRMCNEKCFFLTASLRPCLVDPMEVNDDTDGLPEKAFNKKMPDFNQERSIGPR 485
            |||:.|.:|...|..|:|..|.||...||..|:||:..||.:|||||...|.. .|::||...||
  Rat   198 VEFSGKPAARKALDRCSEGSFLLTTFPRPVTVEPMDQLDDEEGLPEKLVIKNQ-QFHKEREQPPR 261

  Fly   486 FADPNSFEHEYGSRWKQLHNLFKTKQDALKRELKMEEDKLEAQMEYARYEQETELLRQELRKR-- 548
            ||.|.|||:||..|||.|..:.|.:||.:.|.:|...:|||.:||.||:|.:..|:||:|.:|
  Rat   262 FAQPGSFEYEYAMRWKALIEMEKQQQDQVDRNIKEAREKLEMEMEAARHEHQVMLMRQDLMRRQE 326

  Fly   549 ------EVDNERKKLEWEMREKQAEEMRKREEETMRRHQTEMQSHMNRQEEDMLRRQQETL---F 604
                  |:.|:..:...::..:|.||.|:||||            |.||:|:|:|||||..   |
  Rat   327 ELRRMEELHNQEVQKRKQLELRQEEERRRREEE------------MRRQQEEMMRRQQEGFKGTF 379

  Fly   605 MKAQQLNSLLDQQEGFGGGGGGNN 628
            ..|::....:.|. ..||..|.||
  Rat   380 PDAREQEIRMGQM-AMGGAMGINN 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA	NP_727962.1	RRM1_p54nrb_like	301..371	CDD:240778	32/69 (46%)
		RRM2_p54nrb_like	377..456	CDD:240779	39/78 (50%)
		NOPS_NONA_like	447..546	CDD:240580	46/98 (47%)
		GBP_C	<508..613	CDD:303769	40/115 (35%)
		coiled coil	584..595	CDD:293879	4/10 (40%)
		coiled coil	603..613	CDD:293879	2/12 (17%)
Nono	NP_001012356.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		6/24 (25%)
		DBHS. /evidence=ECO:0000250	60..379		143/331 (43%)
		RRM1_p54nrb	78..148	CDD:241032	32/69 (46%)
		RRM_SF	154..233	CDD:302621	39/78 (50%)
		NOPS_p54nrb_PSF_PSPC1	224..316	CDD:240581	43/92 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..476
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347815
Domainoid	1	1.000	74	1.000	Domainoid score	I8891
eggNOG	1	0.900	-	-		E1_KOG0115
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2698
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1274880at2759
OrthoFinder	1	1.000	-	-		FOG0001632
OrthoInspector	1	1.000	-	-		mtm9026
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23189
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1036
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860