DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nonA and Pspc1

DIOPT Version :9

Sequence 1:	NP_727962.1	Gene:	nonA / 32603	FlyBaseID:	FBgn0004227	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001020843.1	Gene:	Pspc1 / 305910	RGDID:	1310122	Length:	522	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	160/408 - (39%)
Similarity:	234/408 - (57%)	Gaps:	20/408 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 GPTFELEPVEVPTETKFSGRNRLYVGNLTNDITDDELREMFKPYGEISEIFSNLDKNFTFLKVDY 346
            |.|.:::....|.|..::.|.||:||||..|||:::.:.:|:.|||.||:|.|.|:.|.|::::.
  Rat    61 GFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLES 125

  Fly   347 HPNAEKAKRALDGSMRKGRQLRVRFAPNATILRVSNLTPFVSNELLYKSFEIFGPIERASITVDD 411
            ...||.||..|||::.|.|.||:|||.:...|.|.||:|.||||||.::|..|||:|:|.:.|||
  Rat   126 RTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDD 190

  Fly   412 RGKHMGEGIVEFAKKSSASACLRMCNEKCFFLTASLRPCLVDPMEVNDDTDGLPEKAFNKKMPDF 476
            ||:..|:|.||||.|..|...|..|.:..|.||.:.||.:|:|||..||.||||||.. :|...:
  Rat   191 RGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLM-QKTQQY 254

  Fly   477 NQERSIGPRFADPNSFEHEYGSRWKQLHNLFKTKQDALKRELKMEEDKLEAQMEYARYEQETELL 541
            ::||...||||.|.:||.||.||||.|..:.|.:::.:.|.::..::||||:||.||:|.:..|:
  Rat   255 HKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLM 319

  Fly   542 RQELRKREVDNERKKLEWEMREKQAEEMRK---REEETMRRHQTEMQSHMNRQEEDMLRRQQETL 603
            ||:|.:|:  .|.::|| |:|.::.::.::   |.||..||.:.||..|   :|::.||||||.
  Rat   320 RQDLMRRQ--EELRRLE-ELRNQELQKRKQIQLRHEEEHRRREEEMIRH---REQEELRRQQEG- 377

  Fly   604 FMKAQQLNSLLDQQEGFGGGGGGNN--STFDNFAGNSNSPFEVFRGNNNNNSTMIGNNAAPNTQE 666
            |......|...:.:.|..|..|..|  ..|......:..|..:...|.||..|:.|....|....
  Rat   378 FKPNYMENREQEMRMGDMGPRGAINMGDAFSPAPAGTQGPPPMMGMNMNNRGTIPGPPMGPGPAM 442

  Fly   667 IKRLDGPINEITSNFSPP 684
                 ||  |..:|...|
  Rat   443 -----GP--EGAANMGTP 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA	NP_727962.1	RRM1_p54nrb_like	301..371	CDD:240778	32/69 (46%)
		RRM2_p54nrb_like	377..456	CDD:240779	39/78 (50%)
		NOPS_NONA_like	447..546	CDD:240580	45/98 (46%)
		GBP_C	<508..613	CDD:303769	38/107 (36%)
		coiled coil	584..595	CDD:293879	3/10 (30%)
		coiled coil	603..613	CDD:293879	2/9 (22%)
Pspc1	NP_001020843.1	RRM1_PSP1	80..150	CDD:241030	32/69 (46%)
		Sufficient for paraspeckles localization. /evidence=ECO:0000250	124..357		104/236 (44%)
		RRM2_PSP1	156..235	CDD:241033	39/78 (50%)
		NOPS_PSPC1	226..319	CDD:240584	42/93 (45%)
		Sufficient for perinucleolar caps localization and interaction with NONO. /evidence=ECO:0000250	230..357		53/130 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I8891
eggNOG	1	0.900	-	-		E1_KOG0115
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2698
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1274880at2759
OrthoFinder	1	1.000	-	-		FOG0001632
OrthoInspector	1	1.000	-	-		mtm9026
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23189
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1036
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.930