DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nonA and nono-1

DIOPT Version :9

Sequence 1:	NP_727962.1	Gene:	nonA / 32603	FlyBaseID:	FBgn0004227	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_498295.3	Gene:	nono-1 / 175844	WormBaseID:	WBGene00017778	Length:	562	Species:	Caenorhabditis elegans

Alignment Length:	409	Identity:	154/409 - (37%)
Similarity:	229/409 - (55%)	Gaps:	46/409 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 NQRQGQNQNQNQVHGQGNQGGPGNQGGAGNQGG---QGNQGGAGNQGNGQGFRGRNAGNNQGGGF 221
            |:|.....:.::|....|...||.:    |:||   :||...|...|.|       .|.|:||..
Worm     8 NRRSNGRDDSSRVAKAENDRKPGRE----NRGGDEKRGNSNNAARSGGG-------GGGNRGGAE 61

  Fly   222 SG-GPQNQQRDNRNRSGPRPGGGAGGAMNSTNMGGGGGGGGGGGPRGGEDFFITQRLRSISGPTF 285
            .| .|..|..||.       ||...|       ||||..||||....|..|..:|.:.
Worm    62 RGIAPAQQPYDNN-------GGHRSG-------GGGGRSGGGGTSFNGAAFTESQLMD------- 105

  Fly   286 ELEPVEVPTETKFSGRNRLYVGNLTNDITDDELREMFKPYGEISEIFSNLDKNFTFLKVDYHPNA 350
                 ||| :.||:||.||:||||.|::.:.||:|:|.|:|:|:|.:.: .|.|.||::|...:|
Worm   106 -----EVP-KKKFTGRCRLFVGNLPNEVKETELKELFSPHGDIAECYLS-GKGFAFLRLDTRAHA 163

  Fly   351 EKAKRALDGSMRKGRQLRVRFAPNATILRVSNLTPFVSNELLYKSFEIFGPIERASITVDDRGKH 415
            |.||.|:||.:..|||:|||||.:...:||..|:|.||||:||.:|..||.:|||...||::|:.
Worm   164 ESAKEAIDGRIIHGRQVRVRFAVHGAAIRVKELSPTVSNEMLYHAFSHFGDVERAVHIVDEKGRP 228

  Fly   416 MGEGIVEFAKKSSASACLRMCNEKCFFLTASLRPCLVDPMEVNDDTDGLPEKAFNKKMPDFNQER 480
            .|||||||.:|.:.:..:....:|.|.||||.:|.:.:.:|..|:.|||.|:.. .:.|..::||
Worm   229 TGEGIVEFERKPNCNEAMAAIRDKVFLLTASPKPLICEVLEPRDEDDGLAERMI-PRTPGLSKER 292

  Fly   481 SIGPRFADPNSFEHEYGSRWKQLHNLFKTKQDALKRELKMEEDKLEAQMEYARYEQETELLRQEL 545
            .:||||..|||||:.||.:||:|:.:.:.::..|..||:....:||:.||.|..:.:.::||::|
Worm   293 ELGPRFPTPNSFEYVYGMKWKELYVVEQKRRAQLDEELRESRRRLESDMELAYQDYQAQMLREDL 357

  Fly   546 RKREVDNERKKLEWEMREK 564
            ::|:.:.||  ||...||:
Worm   358 QRRQQELER--LEAARRER 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA	NP_727962.1	RRM1_p54nrb_like	301..371	CDD:240778	33/69 (48%)
		RRM2_p54nrb_like	377..456	CDD:240779	34/78 (44%)
		NOPS_NONA_like	447..546	CDD:240580	34/98 (35%)
		GBP_C	<508..613	CDD:303769	18/57 (32%)
		coiled coil	584..595	CDD:293879
		coiled coil	603..613	CDD:293879
nono-1	NP_498295.3	RRM1_p54nrb_like	115..184	CDD:240778	33/69 (48%)
		RRM2_p54nrb_like	190..269	CDD:240779	34/78 (44%)
		eNOPS_SF	260..349	CDD:240579	32/89 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163390
Domainoid	1	1.000	66	1.000	Domainoid score	I6530
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	254	1.000	Inparanoid score	I1965
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1274880at2759
OrthoFinder	1	1.000	-	-		FOG0001632
OrthoInspector	1	1.000	-	-		otm14306
orthoMCL	1	0.900	-	-		OOG6_107408
Panther	1	1.100	-	-	LDO	PTHR23189
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4077
SonicParanoid	1	1.000	-	-		X1036
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.930