DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nonA and sfpq

DIOPT Version :9

Sequence 1:	NP_727962.1	Gene:	nonA / 32603	FlyBaseID:	FBgn0004227	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001121427.1	Gene:	sfpq / 100158518	XenbaseID:	XB-GENE-5968416	Length:	659	Species:	Xenopus tropicalis

Alignment Length:	652	Identity:	210/652 - (32%)
Similarity:	305/652 - (46%)	Gaps:	96/652 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 GGGGAVGGPNQNKNFGNNKGG----FVGNRNRNNNRAGNQNR------------TFPGNNNPNQK 121
            ||||  ||.:..:.....:||    :.|:...::||..:||:            ..|......|.
Frog    10 GGGG--GGMSIYRRGNGGRGGGMPNYRGSGYMDSNRGPHQNQQQGPPQQKQQQDKQPAQQQQKQT 72

  Fly   122 PNNETSKADGPNALAKNNE------PATAAAGQNQANQNANKGQNQRQGQNQNQN---------- 170
            |..|...|..|.|..|..:      ||.:...:...:.....|...:|.|:|.|:
Frog    73 PAPEQKPAQQPQAATKPQDSQAPQPPAQSPQSKPAPSPQQKPGTTPQQQQSQPQSSPAKPVPQTP 137

  Fly   171 -----QVHGQGNQGGPGNQGGAGNQGGQGNQGGAGNQGNGQGFRGRNAGNNQGGGFSGGPQNQQR 230
                 :...|..|..|.....|.:|...|......:|...|..|   .|.||.|      |.:..
Frog   138 PQQLQKPPQQPQQQKPAPPNNASSQAKPGQPPVHHHQQQQQRSR---PGMNQVG------QKRPH 193

  Fly   231 DNRNRSGPRPGGGAGGAMNSTNMGGGGGGGGGGGPRGGEDFFITQRLRSISGPTFELEPVEVPTE 295
            .:|.:|.|.|......|....:......|...|             :|:      .|..::.|.|
Frog   194 QSRFQSQPPPHAMESDAAEEKSSADDVSGWSDG-------------VRA------TLSLLKRPGE 239

  Fly   296 TKFSGRNRLYVGNLTNDITDDELREMFKPYGEISEIFSNLDKNFTFLKVDYHPNAEKAKRALDGS 360
            ..::.|.||:||||..||.|||.:::|:.|||..|:|.|..|.|.|:|::....||.||..||..
Frog   240 KTYTQRCRLFVGNLPTDINDDEFKKLFEKYGEPGEVFINKSKGFGFIKLETRALAEIAKAELDDL 304

  Fly   361 MRKGRQLRVRFAPNATILRVSNLTPFVSNELLYKSFEIFGPIERASITVDDRGKHMGEGIVEFAK 425
            ..:|||||||||.::..|.|.||:||||||||.::|..|||:|||.:.|||||:..|:||||||.
Frog   305 PMRGRQLRVRFATHSAALSVRNLSPFVSNELLEEAFSQFGPVERAVVIVDDRGRSTGKGIVEFAA 369

  Fly   426 KSSASACLRMCNEKCFFLTASLRPCLVDPMEVNDDTDGLPEKAFNKKMPDFNQERSIGPRFADPN 490
            |.:|...|..|.:..|.||.:..|.:|:|:|..||.||||||...|... :.:||.:.||||...
Frog   370 KPAARKALERCTDGVFLLTTTPMPVIVEPLEQFDDEDGLPEKLAQKNHL-YQKEREVPPRFAQHG 433

  Fly   491 SFEHEYGSRWKQLHNLFKTKQDALKRELKMEEDKLEAQMEYARYEQETELLRQELRKR------- 548
            :||.||..|||.|..:.|.::..:::.:|..::|||::||.|.:|.:..||||:|.:|
Frog   434 TFEFEYSQRWKSLDEMEKQQRAQVEKNMKEAKEKLESEMEDAYHEHQANLLRQDLMRRQEELRRM 498

  Fly   549 -EVDNERKKLEWEMREKQAEEMRKREEETMRRHQTEMQSHMNRQEEDMLRR-----QQETLFMKA 607
             |:.|:..:...||:.:|.||.|:||||.:.| |.||:..|.||.|:..|.     ::..:.|.|
Frog   499 EELHNQEMQKRKEMQLRQEEERRRREEEMLLR-QREMEEQMRRQREEGYRMSYMDPRERDMRMGA 562

  Fly   608 QQLNSLLD-------QQEGFGGGGGGNNSTFDNFAGNSNSPF--EVFRGNNNNNSTMIGNNAAPN 663
            .|: |:.|       :....||.|.|    ::|..|.:.:..  .:..|:..|...:.||...||
Frog   563 SQM-SMADPYGAASQKYPPLGGAGMG----YENSPGVAQATISSSIMGGDMRNERFVQGNAGTPN 622

  Fly   664 TQ 665
            .|
Frog   623 AQ 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nonA	NP_727962.1	RRM1_p54nrb_like	301..371	CDD:240778	35/69 (51%)
		RRM2_p54nrb_like	377..456	CDD:240779	41/78 (53%)
		NOPS_NONA_like	447..546	CDD:240580	40/98 (41%)
		GBP_C	<508..613	CDD:303769	39/117 (33%)
		coiled coil	584..595	CDD:293879	5/10 (50%)
		coiled coil	603..613	CDD:293879	3/9 (33%)
sfpq	NP_001121427.1	RRM1_PSF	245..315	CDD:241031	35/69 (51%)
		RRM2_p54nrb_like	321..400	CDD:240779	41/78 (53%)
		NOPS_PSF	391..487	CDD:240583	39/96 (41%)
		OmpH	<438..>511	CDD:281871	23/72 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I8956
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2885
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1274880at2759
OrthoFinder	1	1.000	-	-		FOG0001632
OrthoInspector	1	1.000	-	-		mtm9442
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1036
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060