DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment U2af50 and ATU2AF65A

DIOPT Version :9

Sequence 1:	NP_001245708.1	Gene:	U2af50 / 32602	FlyBaseID:	FBgn0005411	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_195387.1	Gene:	ATU2AF65A / 829822	AraportID:	AT4G36690	Length:	573	Species:	Arabidopsis thaliana

Alignment Length:	482	Identity:	177/482 - (36%)
Similarity:	246/482 - (51%)	Gaps:	91/482 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EDKYVNIDNKDRERDRER--------RRHRSRSRDRHRERSRDRRHHRNSRRKPSLYWDVPPPGF 62
            :|.|..  ::||:.||.|        ||.||||:||...|:|.|...::.:|...  :|:.||.
plant   121 DDDYRR--SRDRDHDRRRDDRGGRRSRRSRSRSKDRSERRTRSRSPSKSKQRVSG--FDMAPPA- 180

  Fly    63 EHITPMQYKAMQASGQIPASVVPDTPQT-----------------------AVPVVGST--ITRQ 102
                    .||.|:|......||..|.|                       .:|:...|  .||.
plant   181 --------SAMLAAGAAVTGQVPPAPPTLPGAGMFPNMFPLPTGQSFGGLSMMPIQAMTQQATRH 237

  Fly   103 ARRLYVGNIPFGVTEEEMMEFFNQQMHLVGLAQAA-GSPVLACQINLDKNFAFLEFRSIDETTQA 166
            |||:|||.:.....|:.:..||:|.|..||...|. |..|:...||.:|.|||:|.||::|.:.|
plant   238 ARRVYVGGLSPTANEQSVATFFSQVMAAVGGNTAGPGDAVVNVYINHEKKFAFVEMRSVEEASNA 302

  Fly   167 MAFDGINLKGQSLKIRRPHDYQPMPGIT-----DTPAIKPAVV-----SSGVISTVVPDSPHKIF 221
            |:.|||..:|..:|:|||.||.|....|     .:|.:..|.|     :||.:     :.|.:||
plant   303 MSLDGIIFEGAPVKVRRPSDYNPSLAATLGPSQPSPHLNLAAVGLTPGASGGL-----EGPDRIF 362

  Fly   222 IGGLPNYLNDDQVKELLLSFGKLRAFNLVKDAATGLSKGYAFCEYVDLSITDQSIAGLNGMQLGD 286
            :||||.|..:.||:|||.|||.|:.|:||||..||.|||||||.|.|||:||.:.|.|||:::||
plant   363 VGGLPYYFTESQVRELLESFGGLKGFDLVKDRETGNSKGYAFCVYQDLSVTDIACAALNGIKMGD 427

  Fly   287 KKLIVQRASVGAKNAQNAANTTQSVMLQVPGLSNVV---------------TSGPPTEVLCLLNM 336
            |.|.|:||:             |..|||.|...||:               .....|.|:||..:
plant   428 KTLTVRRAN-------------QGTMLQKPEQENVLLHAQQQIAFQRVMLQPGAVATTVVCLTQV 479

  Fly   337 VTPDELRDEEEYEDILEDIKEECTKYGVVRSVEIPRPI-EGVEVPGCGKVFVEFNSVLDCQKAQQ 400
            ||.|||||:|||.||:||:::|..|:|.:.:|.||||. .|..|.|.||||:::.......:|:.
plant   480 VTEDELRDDEEYGDIMEDMRQEGGKFGALTNVVIPRPSPNGEPVAGLGKVFLKYADTDGSTRARF 544

  Fly   401 ALTGRKFSDRVVVTSYFDPDKYHRREF 427
            .:.||||....||..|:..||:.:.::
plant   545 GMNGRKFGGNEVVAVYYPEDKFEQGDY 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
U2af50	NP_001245708.1	RRM1_U2AF65	103..184	CDD:240676	34/81 (42%)
		RRM2_U2AF65	218..294	CDD:240677	45/75 (60%)
		RRM3_U2AF65	328..415	CDD:240678	40/87 (46%)
ATU2AF65A	NP_195387.1	U2AF_lg	31..571	CDD:273727	177/480 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	93	1.000	Domainoid score	I2560
eggNOG	1	0.900	-	-		E1_KOG0120
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H110853
Inparanoid	1	1.050	282	1.000	Inparanoid score	I867
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D896650at2759
OrthoFinder	1	1.000	-	-		FOG0003153
OrthoInspector	1	1.000	-	-		mtm1083
orthoMCL	1	0.900	-	-		OOG6_101356
Panther	1	1.100	-	-	LDO	PTHR23139
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2550
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.830