DRSC/TRiP Functional Genomics Resources

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Protein Alignment sl and PLC1

DIOPT Version :9

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:NP_015055.1 Gene:PLC1 / 855860 SGDID:S000006189 Length:869 Species:Saccharomyces cerevisiae


Alignment Length:1290 Identity:247/1290 - (19%)
Similarity:382/1290 - (29%) Gaps:609/1290 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 MLERGTIVTKLYGKQRRPDRRHLMLIRETRQLLWATVATQTPRTDYEGAIQLREIREIRVGKHSK 85
            :|:||..:.::  .:||.......||....|::|         .|....::|..:::||:|..:.
Yeast   108 VLQRGIRMIRM--TRRRRKFYEFKLINNNGQIIW---------KDGSKYLELDSVKDIRIGDTAS 161

  Fly    86 EFRLFADDCQRFESSKCFV-ILHGNHFKLKSFSVVALSEIEADNWVRGLRYMVKDTLGAPYPLQI 149
            .::...|..:....||.:: |::....|||:..||||:|::.:.::..:..:||           
Yeast   162 TYQEEVDPKRLRSDSKLWIAIIYKVSNKLKALHVVALNELDFNTFLSCICGLVK----------- 215

  Fly   150 DRWLRRE----------------YYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGK 198
               ||||                ::||    |.|.|..::....::..|.|.........::||:
Yeast   216 ---LRRELMESILLPDNSQFARIHWQI----TVSEKEEDEKKDTLSFADVKKLCDKFHIYVSTGQ 273

  Fly   199 FMEHF-TEDVRRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRP-------A 255
            .:|.| ..|:.....|.:.:|.:          |..:|......|..:|   :..:|       .
Yeast   274 LLEFFQLADINHNGLLNYFEFEK----------FIKILKNRKEVNMIWS---KFTKPPHSHLSFE 325

  Fly   256 ELKQFLETEQ----------------RDVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFV 304
            ...|||.|||                |:.:...:.......|::          ::|||.  |..
Yeast   326 NFFQFLITEQHEQVDRQTAWSYFIKYREPTQLTMGQDGFTKFLK----------EQPYLV--EVK 378

  Fly   305 DFLFSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIE 369
            :.|:||                  ||:.|:|||||||||.|.|.:...|.|.|.:.|:.||||:|
Yeast   379 EELYSK------------------PLNHYFIASSHNTYLLGKQIAETPSVEGYIQVLQQGCRCVE 425

  Fly   370 LDCWNGPDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALI 434
            :|.|:| :|.|.:.||. :||.|....||:.||.:||.:|.||:|:|:|.||:.:.|:..:..:.
Yeast   426 IDIWDG-ENGPVVCHGF-LTSAIPLKTVIRVIKKYAFITSPYPLIISLEINCNKDNQKLASLIMR 488

  Fly   435 EVFGDMLLTQPCDRNEQHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGA 499
            ||..:.|..  .......||||.:|:.||:||.||                              
Yeast   489 EVLAEQLYF--VGTRTDKLPSPRELKHKILLKSKK------------------------------ 521

  Fly   500 HGENDGENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSC 564
                                                         .:|:..|.|.::.|..|.|.
Yeast   522 ---------------------------------------------TSEATRGLSVNEPFPSSFSS 541

  Fly   565 SLNSNMQQ--KQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGD 627
            |..|..:|  :.||.|.|.                                      .|||    
Yeast   542 SYESANEQELRMKDDSTNS--------------------------------------SSAT---- 564

  Fly   628 YSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQ 692
                                 |.|                       :|.|.....:        
Yeast   565 ---------------------NSS-----------------------SMQRIKRIGL-------- 577

  Fly   693 PKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLY 757
             |||.|                          :...|.:|:.                     ::
Yeast   578 -KKHAD--------------------------IINDVSNISG---------------------IH 594

  Fly   758 GIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSN 822
            ||...||                                                          
Yeast   595 GIKFRNF---------------------------------------------------------- 601

  Fly   823 LEENVTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTE 887
                                                                             
Yeast   602 ----------------------------------------------------------------- 601

  Fly   888 DYNSLNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKA 952
               ||.|..|            :|..|..|                                   
Yeast   602 ---SLPESKT------------IAHCFSLN----------------------------------- 616

  Fly   953 IQEAALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFREHSWIFQEMSSFPETKAEKQFFQQ 1017
                                                                  |.|.|.....:
Yeast   617 ------------------------------------------------------ERKVEYMIKDK 627

  Fly  1018 NTQLFLSYH-RNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFR---- 1077
            :.:|.|..| |..:.||||...|..||||||:|||..|.||:|.|:||.|...|||.|.|:    
Yeast   628 HLKLSLDKHNRRYLMRVYPHVLRYKSSNFNPIPFWKAGVQMVATNWQTNDIGQQLNLAMFQILDH 692

  Fly  1078 ---NNGQCGYILKPSFM-----KSDSFNPNNPLC-----DGLSEVKVSIRLIAARHLFR------ 1123
               .:.:.||:|||..:     |:...    ||.     :|...|.|.||:::.:.|.|      
Yeast   693 QPDGSFKSGYVLKPKKLLPVVTKAKMI----PLIYEHFENGSDPVTVKIRILSTQLLPRLNDTSP 753

  Fly  1124 GGKSNNPQIVVEL-------IGASFDTGVKY-----RTKVNE-NGFNPVWNESCEFNVRNPQFAI 1175
            ...:.|..:.||.       :..|.|.|.:.     .||.:: |||||:|:......:::.....
Yeast   754 SRNNTNSFVKVEFHTDDEPTMPISIDKGTRISATEASTKSSQGNGFNPIWDAEVSITLKDTDLTF 818

  Fly  1176 LRFEVQDEDMFAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKI 1230
            ::|.|..|    ||. ||..|..|..:|.|||.:.|.|...|:....:|.|:.:|
Yeast   819 IKFMVISE----ETQ-IASVCLKLNYLRMGYRHIPLFNMEGEQYIFCTLFIHTQI 868

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 28/125 (22%)
PI-PLCc_gamma 323..>470 CDD:176534 61/146 (42%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 7/97 (7%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 8/99 (8%)
SH3_PLCgamma 828..880 CDD:212759 0/51 (0%)
PLCYc 981..1091 CDD:128454 39/117 (33%)
C2_PLC_like 1109..1215 CDD:175974 35/124 (28%)
PLC1NP_015055.1 PH_PLC_fungal 124..224 CDD:241514 27/122 (22%)
PLN02952 284..856 CDD:178538 199/1071 (19%)
PI-PLC1c_yeast 379..688 CDD:176540 135/774 (17%)
C2_PLC_like 732..868 CDD:175974 38/140 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157346487
Domainoid 1 1.000 118 1.000 Domainoid score I1280
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 241 1.000 Inparanoid score I690
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R928
SonicParanoid 1 1.000 - - X101
TreeFam 1 0.960 - -
87.780

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