DRSC/TRiP Functional Genomics Resources

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Protein Alignment sl and Plcl1

DIOPT Version :10

Sequence 1:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster
Sequence 2:NP_445908.2 Gene:Plcl1 / 84587 RGDID:708420 Length:1096 Species:Rattus norvegicus


Alignment Length:1282 Identity:259/1282 - (20%)
Similarity:416/1282 - (32%) Gaps:581/1282 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 FSAM-SAPLLGEMEQTIGMLERGTIVTKLYGKQRRPD----RRHLMLIRETRQLLWATVATQTPR 63
            ||:| |...:......|..::.|..:.|:     ||:    .|...|..:.:.|.|     :..:
  Rat    97 FSSMPSEKKISSAHDCISFMQAGCELKKV-----RPNSRIYNRFFTLDTDLQALRW-----EPSK 151

  Fly    64 TDYEGA-IQLREIREIRVGKHSKEFR------LFADDCQRFESSKCFVILHGNHFKLKSFSVVAL 121
            .|.|.| :.:..|:|||:||:::.||      ...:||       .|.||||.::  :|..:||.
  Rat   152 KDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDC-------AFSILHGENY--ESLDLVAN 207

  Fly   122 SEIEADNWVRGLRYMVKDTLGAPYPLQIDR---------WLRREY---------YQIENVNTHSA 168
            |...|:.||.||||:|.   .:..||....         ||:..:         ..:|:.:....
  Rat   208 SADVANIWVSGLRYLVS---RSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELI 269

  Fly   169 K----ATEQSPAQVTIKDFKLFLAGVSCKMTTGKFMEHFTEDVRRKHDLKFDDFSRLYQKLLLPN 229
            |    ..::|..::..|:.:.....::.::|..:|.|.|.|...|         ..:|..|:   
  Rat   270 KQLNPTLKESKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTR---------PEVYFLLV--- 322

  Fly   230 GFASVLSGSGVANFPYSEDQQVVRPAELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERD-V 293
                          ..|::::.:...:|..|||.||   ..:.::.......||.:  ::..| .
  Rat   323 --------------QISKNKEYLDANDLMLFLEVEQ---GVTHVTEDMCLDIIRRY--ELSEDGR 368

  Fly   294 QEPYLTFPEFVDFLFSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYA 358
            |:.:|....|..:|.|.:.|:::.:..:|..||..|||.|:|.:||||||..|||...:....|.
  Rat   369 QKGFLAIDGFTQYLLSPECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYV 433

  Fly   359 RALRMGCRCIELDCWNGPDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSL 423
            |||:||||.||||..:||||.|.:.:.:.:...:.|..|::.|...||.:||||:||.:..:|||
  Rat   434 RALKMGCRSIELDVSDGPDNEPILCNRNNMAMLLSFRSVLEVINKFAFVASEYPLILCLGNHCSL 498

  Fly   424 EQQRNMAQALIEVFGDMLLTQPCDRNEQHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGH 488
            .|||.|.|.:.:|||:.|.|:....:|.:||||.:|:..||:|.||||                 
  Rat   499 PQQRVMVQQMKKVFGNKLYTEAPLSSESYLPSPEKLKHMIIVKGKKLP----------------- 546

  Fly   489 RSSLGGAGGGAHGENDGENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNS 553
                                                                            |
  Rat   547 ----------------------------------------------------------------S 547

  Fly   554 EDDDFGLSSSCSLNSNMQQKQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLV 618
            |.|                                                              
  Rat   548 ESD-------------------------------------------------------------- 550

  Fly   619 RESATFVGDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFS 683
                                                 |:|..|.|                    
  Rat   551 -------------------------------------LLEGEVTD-------------------- 558

  Fly   684 IILKEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHC 748
                         ||:|                                                
  Rat   559 -------------EDEE------------------------------------------------ 562

  Fly   749 RIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDN 813
                                              .::|..||                       
  Rat   563 ----------------------------------AEMSRRVS----------------------- 570

  Fly   814 GASNYMGSNLEENVTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANY 878
                                                              |||.|. :||:    
  Rat   571 --------------------------------------------------GDYNGE-QKHI---- 580

  Fly   879 VKVIDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQ 943
                                                                             
  Rat   581 ----------------------------------------------------------------- 580

  Fly   944 ETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFR--------EHSWIFQ 1000
                 |:                          .:|:|||:...:||.:|        ::.|   
  Rat   581 -----WL--------------------------CRELSDLVSICKSVQYRDFELSMKTQNYW--- 611

  Fly  1001 EMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTG 1065
            |:.||.||.|.: ...:..:.|::|::..:|||||...|:||||.||..|||.|.|::|:|:||.
  Rat   612 EICSFSETLASR-IANEYPEDFVNYNKKFLSRVYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTP 675

  Fly  1066 DKAMQLNQAKFRNNGQCGYILKPSFMKSD--SFNPNNP-LCDGLSEVKVSIRLIAARHLFR---- 1123
            ...|.|:...|..||.|||:|:||.|:.:  .|:.|.. :..|:|.:.:.|::|:.::..:    
  Rat   676 GPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGIVPGVSPLLLHIKIISGQNFPKPKGA 740

  Fly  1124 --GGKSNNPQIVVELIGASFDTGVKYRTK-VNENGFNPVWNESCEFNVRNPQFAILRFEVQDEDM 1185
              .|...:|.:.||:.|...|.. :.||| |.:|..||:::|:.||.|..|:..::||.:.|:|.
  Rat   741 CAKGDVIDPYVCVEIHGIPADCS-EQRTKTVQQNSDNPIFDETFEFQVNLPELTMVRFVILDDDY 804

  Fly  1186 FAETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKIAN 1232
            ..: .||.|...|..|::.|||.|.||:...:.:|..:|.::|.|.|
  Rat   805 IGD-EFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITN 850

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 38/135 (28%)
EFh_PI-PLCgamma 152..311 CDD:320031 29/172 (17%)
EF-hand motif 152..191 CDD:320031 6/51 (12%)
EF-hand motif 198..226 CDD:320031 6/27 (22%)
EF-hand motif 230..265 CDD:320031 5/34 (15%)
EF-hand motif 277..311 CDD:320031 8/34 (24%)
PI-PLCc_gamma 323..>470 CDD:176534 67/146 (46%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 4/97 (4%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 6/99 (6%)
SH3_PLCgamma 828..880 CDD:212759 6/51 (12%)
PLCYc 981..1091 CDD:128454 47/117 (40%)
C2_PLC_like 1109..1215 CDD:175974 35/112 (31%)
Plcl1NP_445908.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..101 2/3 (67%)
Interaction with PPP1C 83..222 41/143 (29%)
PH_PLC_eta 116..224 CDD:270170 37/126 (29%)
EFh_PI-PLC 244..386 CDD:333715 29/172 (17%)
EF-hand motif 244..273 CDD:320029 4/28 (14%)
EF-hand motif 280..311 CDD:320029 5/30 (17%)
EF-hand motif 316..344 CDD:320029 7/44 (16%)
EF-hand motif 353..386 CDD:320029 8/34 (24%)
PI-PLCc_PRIP_metazoa 399..689 CDD:176539 130/762 (17%)
Interaction with GABA A beta subunit 544..568 14/318 (4%)
C2_PLC_like 721..849 CDD:175974 38/129 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1067..1096
Blue background indicates that the domain is not in the aligned region.

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