DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sl and PLC4

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	NP_001318832.1	Gene:	PLC4 / 835984	AraportID:	AT5G58700	Length:	597	Species:	Arabidopsis thaliana

Alignment Length:	1075	Identity:	208/1075 - (19%)
Similarity:	330/1075 - (30%)	Gaps:	523/1075 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 KMTTGKFMEHFTEDVRRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQVVRPAEL 257
            :|.:.||...||...|.......:|...|::|                    |:|....:.|.:|
plant     6 EMGSYKFCLIFTRKFRMTESGPVEDVRDLFEK--------------------YTEGDAHMSPEQL 50

  Fly   258 KQFLETEQRDVSASEISSAAIASFIRDFVQDVERDVQEPY-------------LTFPEFVDFLFS 309
            ::.:..|..:...|              :::.||.|.|..             ||..:|..:|||
plant    51 QKLMTEEGGEGETS--------------LEEAERIVDEVLRRKHHIAKFTRRNLTLDDFNYYLFS 101

  Fly   310 KQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCW- 373
              .||.....|||..:|:.|||.|:|.:.||:||||:|.||..|....|.|||.|.|.:|||.|
plant   102 --TDLNPPIADQVHQNMDAPLSHYFIFTGHNSYLTGNQLSSNCSELPIADALRRGVRVVELDLWP 164

  Fly   374 NGPDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFG 438
            .|.|:: .:.||.|:|.::|....:::||.:||..|:||||:::|.:.:.:.|..:|:.:.:.||
plant   165 RGTDDV-CVKHGRTLTKEVKLGKCLESIKANAFAISKYPVIITLEDHLTPKLQFKVAKMITQTFG 228

  Fly   439 DMLL---TQPCDRNEQHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGAGGGAH 500
            |||.   :|.|    |..|||.:|:.||::..|...::.: ||......:            |..
plant   229 DMLYYHDSQGC----QEFPSPEELKEKILISTKPPKEYLE-ANDTKEKDN------------GEK 276

  Fly   501 GENDGENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCS 565
            |::..|:|.....|.|:..:..:||               .:|.:|:.   |.:|::.|   ||.
plant   277 GKDSDEDVWGKEPEDLISTQSDLDK---------------VTSSVNDL---NQDDEERG---SCE 320

  Fly   566 LNSNMQQKQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSL 630
            .:::.|.:..:......:|      .||.:||
plant   321 SDTSCQLQAPEYKRLIAIH------AGKPKGG--------------------------------- 346

  Fly   631 SFWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKK 695
                      .|:.||.:
plant   347 ----------LRMALKVD----------------------------------------------- 354

  Fly   696 HEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGID 760
                    ||                                      ||:
plant   355 --------PN--------------------------------------KIR-------------- 359

  Fly   761 TMNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEE 825
                                   :||  :|::||.:|:|
plant   360 -----------------------RLS--LSEQLLEKAVA-------------------------- 373

  Fly   826 NVTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDSTTEDYN 890
                                                   .||
plant   374 ---------------------------------------SYG----------------------- 376

  Fly   891 SLNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWIKAIQE 955

plant   377 ----------------------------------------------------------------- 376

  Fly   956 AALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFREHSWIFQEMSSFPETKAEKQFFQQNTQ 1020
                                     :|:|                            :|.|:|
plant   377 -------------------------ADVI----------------------------RFTQKN-- 386

  Fly  1021 LFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNGQCGYI 1085
             ||        |:||||.|.:|||:.|...|..|:||||.|.|...:|:.|.:..||.||.|||:
plant   387 -FL--------RIYPKGTRFNSSNYKPQIGWMSGAQMIAFNMQGYGRALWLMEGMFRANGGCGYV 442

  Fly  1086 LKPSFM-----------KSDSFNPNNPL----CDG---LSEVKVSIRLIAARHLFRGGKSNNPQ- 1131
            .||.|:           ..|:.:|...|    |.|   |.:.|.:       |.    .|.:|.
plant   443 KKPDFLMDASPNGQDFYPKDNSSPKKTLKVKVCMGDGWLLDFKKT-------HF----DSYSPPD 496

  Fly  1132 --IVVELIGASFDTGVKYRTKVNENGFNPVWNESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQ 1194
              :.|.:.||..|. |..:||:..:.:.|:||:...|.:..|:.|:||.||.:.|:..:..|..|
plant   497 FFVRVGIAGAPVDE-VMEKTKIEYDTWTPIWNKEFTFPLAVPELALLRVEVHEHDVNEKDDFGGQ 560

  Fly  1195 ACYPLTCIRQGYRSVILRNKFSEELELSSLLINIK 1229
            .|.|::.||||.|:|.|.|:...:...:.||:..:
plant   561 TCLPVSEIRQGIRAVPLFNRKGVKYSSTRLLMRFE 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168
		PI-PLCc_gamma	323..>470	CDD:176534	60/150 (40%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	8/97 (8%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	9/99 (9%)
		SH3_PLCgamma	828..880	CDD:212759	2/51 (4%)
		PLCYc	981..1091	CDD:128454	36/109 (33%)
		C2_PLC_like	1109..1215	CDD:175974	34/108 (31%)
PLC4	NP_001318832.1	PLN02230	1..597	CDD:177875	208/1075 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	112	1.000	Domainoid score	I2055
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I1114
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2757
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X101
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.830