DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sl and PLC5

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	NP_001332556.1	Gene:	PLC5 / 835983	AraportID:	AT5G58690	Length:	578	Species:	Arabidopsis thaliana

Alignment Length:	1014	Identity:	196/1014 - (19%)
Similarity:	301/1014 - (29%)	Gaps:	508/1014 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 YSEDQQVVRPAELKQFLETEQRDVSASEISSAA------------IASFIRDFVQDVERDVQEPY 297
            |:|.:..:...:|.:|| .|.:|.:...:|.|.            |..|:|.            .
plant    36 YTEGRSHMTAEQLCRFL-VEVQDETEVLVSDAEKIIERITCERHHITKFLRH------------T 87

  Fly   298 LTFPEFVDFLFSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALR 362
            |...:|..||||  :||.:....:|..||..|||.|:|.:|||:||||:|.:||.|.....:||:
plant    88 LNLDDFFSFLFS--DDLNHPIDSKVHQDMASPLSHYFIYTSHNSYLTGNQINSECSDVPLIKALK 150

  Fly   363 MGCRCIELDCW-NGPDNLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQ 426
            .|.|.:|||.| |...:...:.||...|..::.:..:::||:|||.:|.|||||::|.:.:.:.|
plant   151 RGVRALELDMWPNSTKDDILVLHGWAWTPPVELVKCLRSIKEHAFYASAYPVILTLEDHLTPDLQ 215

  Fly   427 RNMAQALIEVFGDMLLTQPCDRNEQHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSS 491
            ...|:.:.|:|.||:.. |.....:..|||..|:.||::..|. |:           |||
plant   216 AKAAEMMKEIFMDMVYF-PEAGGLKEFPSPEDLKYKIVISTKP-PK-----------GSL----- 262

  Fly   492 LGGAGGGAHGENDGENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDD 556
                             ||             ||                          :||.|
plant   263 -----------------RK-------------DK--------------------------DSESD 271

  Fly   557 DFGLSSSCSLNSNMQQKQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRES 621
            ..|.:||            |.||:||          |.|....||       |:..||
plant   272 ASGKASS------------DVSADDE----------KTEEETSEA-------KNEEDG------- 300

  Fly   622 ATFVGDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIIL 686
                                                    ||.
plant   301 ----------------------------------------FDQ---------------------- 303

  Fly   687 KEPVPQPKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIM 751
                                                       :|.|
plant   304 -------------------------------------------ESSN------------------ 307

  Fly   752 QEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGAS 816
                   :|.:.:..|:::                                    ..|:..||
plant   308 -------LDFLTYSRLITI------------------------------------PSGNAKNG-- 327

  Fly   817 NYMGSNLEENVTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKV 881
                  |:|.:|.                                   |.||:
plant   328 ------LKEALTI-----------------------------------DNGGV------------ 339

  Fly   882 IDSTTEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETA 946

plant   340 ----------------------------------------------------------------- 339

  Fly   947 YEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFREHSWIFQEMSSFPETKAE 1011
                                                     |.:..||
plant   340 -----------------------------------------RRLSLRE----------------- 346

  Fly  1012 KQFFQQNTQLF----LSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLN 1072
             |.|::.|:::    :.:.:..:.|:|||..|::|||:.|...|..|:||:|.|.|...:|:.:.
plant   347 -QKFKKATEMYGTEVIKFTQKNLLRIYPKATRVNSSNYRPYNGWMYGAQMVAFNMQGYGRALWMM 410

  Fly  1073 QAKFRNNGQCGYILKPSFMKSDS-----FNPNNPLCDGLSEVKVSIRLIA----------ARHLF 1122
            ...||.||.|||:.||.||.:::     |||...|     .:|.::::..          .|..|
plant   411 HGMFRGNGGCGYVKKPDFMMNNNLSGEVFNPKAKL-----PIKKTLKVKVYMGKGWDSGFQRTCF 470

  Fly  1123 RGGKSNNPQIVVELIGASFDTGVKYRTKVNENGFNPVWNESCEFNVRNPQFAILRFEVQDEDMFA 1187
            ....|.|....|.:.|...|..:| :||..:..:.|.|||..||.:..|:.|:||.||.|.:|..
plant   471 NTWSSPNFYTRVGITGVRGDKVMK-KTKKEQKTWEPFWNEEFEFQLTVPELALLRIEVHDYNMPE 534

  Fly  1188 ETHFIAQACYPLTCIRQGYRSVILRNKFSEELELSSLLI 1226
            :..|..|.|.|::.:|||.|||.|.::..|.|...:||:
plant   535 KDDFSGQTCLPVSELRQGIRSVPLYDRKGERLVSVTLLM 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168
		PI-PLCc_gamma	323..>470	CDD:176534	56/147 (38%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	9/97 (9%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	4/99 (4%)
		SH3_PLCgamma	828..880	CDD:212759	4/51 (8%)
		PLCYc	981..1091	CDD:128454	32/113 (28%)
		C2_PLC_like	1109..1215	CDD:175974	36/115 (31%)
PLC5	NP_001332556.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	112	1.000	Domainoid score	I2055
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I1114
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2757
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.830