DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sl and PLC1

DIOPT Version :9

Sequence 1:	NP_476726.2	Gene:	sl / 32601	FlyBaseID:	FBgn0003416	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	NP_195565.2	Gene:	PLC1 / 830010	AraportID:	AT4G38530	Length:	564	Species:	Arabidopsis thaliana

Alignment Length:	1012	Identity:	179/1012 - (17%)
Similarity:	289/1012 - (28%)	Gaps:	512/1012 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 PAELKQFLETEQRDVSASEISSAAIASFIR----------DFVQDVERDVQ-------EPYLTFP 301
            |..:|:..|...|:   .::|...:..|:.          |:|||:...|:       ...:...
plant    23 PVSIKRLFEAYSRN---GKMSFDELLRFVSEVQGERHAGLDYVQDIFHSVKHHNVFHHHGLVHLN 84

  Fly   302 EFVDFLFSKQNDLWNSKYDQVFMDMNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCR 366
            .|..:|||..|...... .||..||..|||.|::.:.||:||||:|.:|.||.|...:|||.|.:
plant    85 AFYRYLFSDTNSPLPMS-GQVHHDMKAPLSHYFVYTGHNSYLTGNQVNSRSSVEPIVQALRKGVK 148

  Fly   367 CIELDCWNGPD-NLPYIFHGHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMA 430
            .||||.|..|. |...:.||.|:||.......:..|||:||..|:||||:::|.:...:.|..:|
plant   149 VIELDLWPNPSGNAAEVRHGRTLTSHEDLQKCLTAIKDNAFHVSDYPVIITLEDHLPPKLQAQVA 213

  Fly   431 QALIEVFGDMLLTQPCDRNEQHLPSPYQLRRKIILKHKKLPQFDDIANGISSTGSLGHRSSLGGA 495
            :.|.:.:..||..: ...:.:|.|||.:|:.||::                ||
plant   214 KMLTKTYRGMLFRR-VSESFKHFPSPEELKGKILI----------------ST------------ 249

  Fly   496 GGGAHGENDGENVRKVFKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGL 560
                                    |.|              :|.:.|..::.:|.
plant   250 ------------------------KPP--------------KEYLESKTVHTTRT---------- 266

  Fly   561 SSSCSLNSNMQQKQKDTSANDELHFGENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFV 625
                       ...|:||.|                  :.|:.:|::||.
plant   267 -----------PTVKETSWN------------------RVANKILEEYKD--------------- 287

  Fly   626 GDYSLSFWRRNRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPV 690

plant   288 ----------------------------------------------------------------- 287

  Fly   691 PQPKKHEDQEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGR 755
                                                                         .|..
plant   288 -------------------------------------------------------------MESE 291

  Fly   756 LYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMG 820
            ..|                     ||::...|                           |:|
plant   292 AVG---------------------YRDLIAIH---------------------------AAN--- 305

  Fly   821 SNLEENVTCKALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVKVIDST 885
                    ||
plant   306 --------CK------------------------------------------------------- 307

  Fly   886 TEDYNSLNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPTMQNPFVIGFDNQETAYEWI 950
                        |...|.:           |:||             :.|..:..|.|     |:
plant   308 ------------DPSKDCL-----------SDDP-------------EKPIRVSMDEQ-----WL 331

  Fly   951 KAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFREHSWIFQEMSSFPETKAEKQFF 1015
            ..:                      |....:||:                            :|.
plant   332 DTM----------------------VRTRGTDLV----------------------------RFT 346

  Fly  1016 QQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGSQMIALNYQTGDKAMQLNQAKFRNNG 1080
            |:|           :.|:||||.|:||||::|...|..|:||:|.|.|...|.:.:.|..||.||
plant   347 QRN-----------LVRIYPKGTRVDSSNYDPHVGWTHGAQMVAFNMQGHGKQLWIMQGMFRGNG 400

  Fly  1081 QCGYILKPSFMKSDS--FNPNNPLCDGLSEVKVSIRLIAARHLFRG------------GKSNNPQ 1131
            .|||:.||..:..:.  |:|    |... .:|.::::    .::.|            .:.:.|.
plant   401 GCGYVKKPRILLDEHTLFDP----CKRF-PIKTTLKV----KIYTGEGWDLDFHHTHFDQYSPPD 456

  Fly  1132 IVVE--LIGASFDTGVKYRTKVNENGFNPVW-NESCEFNVRNPQFAILRFEVQDEDMFAETHFIA 1193
            ..|:  :.|...|| |.|||:...:.:.|:| |:...|.:..|:.|:|.|:|||.|...:..|..
plant   457 FFVKIGIAGVPRDT-VSYRTETAVDQWFPIWGNDEFLFQLSVPELALLWFKVQDYDNDTQNDFAG 520

  Fly  1194 QACYPLTCIRQGYRSVILRNKFSEELELSSLLINIKI 1230
            |.|.||..::.|.|:|.|.::..:..:.:.||::..:
plant   521 QTCLPLPELKSGVRAVRLHDRTGKAYKNTRLLVSFAL 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sl	NP_476726.2	PH_PLC_gamma	22..147	CDD:270168
		PI-PLCc_gamma	323..>470	CDD:176534	56/147 (38%)
		SH2_N-SH2_PLC_gamma_like	584..682	CDD:199829	4/97 (4%)
		SH2_C-SH2_PLC_gamma_like	696..796	CDD:198186	5/99 (5%)
		SH3_PLCgamma	828..880	CDD:212759	2/51 (4%)
		PLCYc	981..1091	CDD:128454	34/109 (31%)
		C2_PLC_like	1109..1215	CDD:175974	32/120 (27%)
PLC1	NP_195565.2	PLN02228	1..564	CDD:177873	179/1012 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	112	1.000	Domainoid score	I2055
eggNOG	1	0.900	-	-		E1_KOG0169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I1114
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368239at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2757
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X101
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.830